Hematopoietic origin of microglial and perivascular cells in brain

Hess, David C.; Abe, Takanori; Hill, William; Studdard, Angeline Martin; Carothers, Jo; Masuya, Masahiro; Fleming, Paul; Drake, Christopher J.; Ogawa, Makio

doi:10.1016/j.expneurol.2003.11.005

Cited by 249 publications

(214 citation statements)

References 28 publications

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“…Stroke damage adjacent to the SVZ induces neuroblast migration from GFAPexpressing progenitor cells (Yamashita et al, 2006). Alternatively, after cardiac, limb, or brain ischemia, bone marrowderived cells or EPCs are mobilized into the peripheral circulation, in which they proliferate and give rise to local endothelial cells, macrophage or microglial cells after stroke, and pericytes (Zhang et al, 2002;Hess et al, 2004;Kokovay et al, 2006). Circulating EPCs may also give rise to new neurons after stroke (Hess et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, after cardiac, limb, or brain ischemia, bone marrowderived cells or EPCs are mobilized into the peripheral circulation, in which they proliferate and give rise to local endothelial cells, macrophage or microglial cells after stroke, and pericytes (Zhang et al, 2002;Hess et al, 2004;Kokovay et al, 2006). Circulating EPCs may also give rise to new neurons after stroke (Hess et al, 2004). The present study uses BrdU and lentiviral labeling within the SVZ, cell morphology, DCX staining, and the exclusion of markers for other cell types to identify these migrating post-stroke cells as immature neurons that are born within the SVZ and migrate up to 4 mm into peri-infarct cortex.…”

Section: Discussionmentioning

confidence: 99%

“…However, ischemia mobilizes bone marrow-derived endothelial precursor cells (EPCs) that incorporate into blood vessels after ischemia (Zhang et al, 2002;Hristov and Weber, 2004) and may form neurons in situ near stroke (Hess et al, 2004). Local neurogenesis from the SVZ to the striatum derives from a GFAP expression progenitor (Yamashita et al, 2006).…”

Section: Post-stroke Neurogenesis Derives From a Gfap-expressing Progmentioning

confidence: 99%

See 2 more Smart Citations

A Neurovascular Niche for Neurogenesis after Stroke

Ohab¹,

Fleming²,

Blesch³

et al. 2006

J. Neurosci.

781

762

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Stroke causes cell death but also birth and migration of new neurons within sites of ischemic damage. The cellular environment that induces neuronal regeneration and migration after stroke has not been defined. We have used a model of long-distance migration of newly born neurons from the subventricular zone to cortex after stroke to define the cellular cues that induce neuronal regeneration after CNS injury. Mitotic, genetic, and viral labeling and chemokine/growth factor gain-and loss-of-function studies show that stroke induces neurogenesis from a GFAP-expressing progenitor cell in the subventricular zone and migration of newly born neurons into a unique neurovascular niche in peri-infarct cortex. Within this neurovascular niche, newly born, immature neurons closely associate with the remodeling vasculature. Neurogenesis and angiogenesis are causally linked through vascular production of stromal-derived factor 1 (SDF1) and angiopoietin 1 (Ang1). Furthermore, SDF1 and Ang1 promote post-stroke neuroblast migration and behavioral recovery. These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Post-stroke Neurogenesis Derives From a Gfap-expressing Progmentioning

confidence: 99%

See 1 more Smart Citation

A Neurovascular Niche for Neurogenesis after Stroke

Ohab¹,

Fleming²,

Blesch³

et al. 2006

J. Neurosci.

781

762

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“…This hypothetical possibility that HSCs are fully plastic and able to trans-dedifferentiate raised much hope that HSCs isolated from BM, mobilized peripheral blood (mPB), or cord blood (CB) could become a universal source of SCs for tissue/organ repair. This excitement was bolstered by several reports demonstrating the remarkable regenerative potential of HSCs in animal models, e.g., after heart infarct (Orlic et al, 2001), stroke (Hess et al, 2004), spinal cord injury (Corti et al, 2002), and liver damage (Petersen et al, 1999). However, despite such promise, the role of BM SCs in the repair of damaged organs has become controversial (Orkin and Zon, 2002;Wagers et al, 2002).…”

Section: Bm-derived Stem Cells and Their Potential Role In Regeneratimentioning

confidence: 99%

Very small embryonic-like (VSEL) stem cells in adult organs and their potential role in rejuvenation of tissues and longevity

Ratajczak

Zuba‐Surma

Shin

et al. 2008

Experimental Gerontology

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Recently, we purified rare CXC chemokine receptor 4 expressing (CXCR4 + ) small stem cells (SCs) from the murine bone marrow (BM) that express markers characteristic for embryonic (E)SCs, epiblast (EP)SCs, and primordial germ cells (PGCs). We named these primitive cells very small embryonic-like (VSEL) SCs (VSELs). Our data indicate that VSELs are also present in many other organs in mice and that they may differentiate into cells from all three germ layers. Similar SCs were also isolated from human cord blood (CB) and mobilized peripheral blood (mPB). We hypothesize that VSELs are deposited during gastrulation and organogenesis in developing organs/tissues of mammals as a population of pluripotent stem cells (PSCs) that give rise to tissue committed monopotent SCs and that their number decreases with age. Therefore VSELs could play a pivotal role in normal rejuvenation of adult tissues as well as involvement in regeneration of damaged organs. Thus, these cells are potential SCs candidates for regenerative medicine and we envision that the regenerative potential of these cells could be harnessed to decelerate the aging processes.

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“…This excitement was bolstered at that time by several reports that demonstrated the remarkable regenerative potential of "HSC" in animal models, for example, after heart infarct (Orlic et al, 2001), stroke (Hess et al, 2004), spinal cord injury (Corti et al, 2002a), and liver damage (Petersen et al, 1999).…”

Section: Bm-derived Stem Cells and Tissue/organ Regeneration: Evidencmentioning

confidence: 99%

Bone marrow‐derived very small embryonic‐like stem cells: Their developmental origin and biological significance

Kucia

Wan

Ratajczak

2007

Developmental Dynamics

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Data from our and other laboratories provide evidence that bone marrow (BM) contains a population of stem cells that expresses early developmental markers such as (1) stage-specific embryonic antigen (SSEA) and (2) transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells, and primordial germ cells (PGC). The presence of these stem cells in adult BM supports the concept that this organ contains some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. We hypothesize that these cells could be direct descendants of the germ lineage that, to pass genes on to the next generations, has to create soma and, thus, becomes a "mother lineage" for all somatic cell lineages present in the adult body. Germ potential is established after conception in totipotent zygotes and retained in blastomeres of morula, cells from the inner cell mass of blastocyst, epiblast, and population of PGC. We will present a concept that SSEA ؉ Oct-4 ؉ Nanog ؉ cells identified in BM could be descendants of epiblast cells as well as some rare migrating astray PGC. Developmental Dynamics 236:3309 -3320, 2007.

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Hematopoietic origin of microglial and perivascular cells in brain

Cited by 249 publications

References 28 publications

A Neurovascular Niche for Neurogenesis after Stroke

A Neurovascular Niche for Neurogenesis after Stroke

Very small embryonic-like (VSEL) stem cells in adult organs and their potential role in rejuvenation of tissues and longevity

Bone marrow‐derived very small embryonic‐like stem cells: Their developmental origin and biological significance

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