2004
DOI: 10.1182/blood.v104.11.672.672
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Hematopoietic Origin of Fibroblasts and Their Precursors.

Abstract: Recent studies indicate that hematopoietic stem cells (HSCs) are capable of reconstituting a number of non-hematopoietic organs and tissues. To define the potential of the HSC precisely, we initiated transplantation studies of a clonal population of cells derived from a single HSC. We used the bone marrow (BM) of transgenic enhanced green fluorescent protein (EGFP) mice as the source of donor HSCs. We demonstrated the HSC origin of glomerular mesangial cells (Masuya et al, Blood 101: 2215, 2003) and brain micr… Show more

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“…However, these reports not only showed the possibility that hematopoietic stem cells do not differentiate but also that bone marrow-derived cells fuse to recipient tissue cells 16 , 17 . In recent years, several papers have denied the plasticity of bone marrow stem cells 18 , 19 . However, the bone marrow includes hematopoietic stem cells, mesenchymal stem cells, and somatic pluripotent progenitor cells, and mesenchymal stem cells only comprise 0.001-0.01% of cells in the bone marrow.…”
Section: Discussionmentioning
confidence: 99%
“…However, these reports not only showed the possibility that hematopoietic stem cells do not differentiate but also that bone marrow-derived cells fuse to recipient tissue cells 16 , 17 . In recent years, several papers have denied the plasticity of bone marrow stem cells 18 , 19 . However, the bone marrow includes hematopoietic stem cells, mesenchymal stem cells, and somatic pluripotent progenitor cells, and mesenchymal stem cells only comprise 0.001-0.01% of cells in the bone marrow.…”
Section: Discussionmentioning
confidence: 99%