“…HIFs are heterodimers comprising two basic helix-loop-helix proteins (the HIFα and HIFβ subunits), which recognize the hypoxia response element (HRE, entailing the G/ACGTG motif) in the promoter of several genes, with major roles in different cell functions, including cellular metabolism, survival and proliferation, and in processes, such as angiogenesis, hematopoiesis and inflammation [17]. Whereas the expression of HIF1α protein is ubiquitous, the cellular expression of the HIF2α subunit is rather restricted to certain cells, for instance, cells of hematopoietic origin, ECs, adipocytes, glial cells and interstitial cells of the kidney [18,19,20,21,22,23]. While there is some functional overlap of both HIF isoforms, HIF1α and HIF2α also have distinct functions, each specifically regulating different genes.…”