Hematopoietic colony-forming cells from mice after wound trauma

Ledney, G D; Stewart, Dennis A.; Gruber, Dale F.; Gelston, H. M.; Exum, E. D.

doi:10.1016/0022-4804(85)90010-1

Cited by 17 publications

(9 citation statements)

References 16 publications

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“…Besides the data described in the current paper, there are other reports of reduced mortality by combining radiation with skin injuries, usually wounding (Langendorff et al 1964, Ledney et al 1981, Ledney et al 1985a, Ledney et al 1985b, Stromberg et al 1968). In most studies the timing of the wound with respect to radiation played an important role in the outcome (Ledney et al 1981, Ledney et al 1985a, Stromberg et al 1968).…”

Section: Discussionsupporting

confidence: 53%

“…However some studies describe improved survival of mice up to one month after total body irradiation (Ledney et al 1981, Ledney et al 1985a, Ledney et al 1985b) with wounding of the skin in a narrow window of time before or after irradiation. Though the skin and bone marrow were involved in these examples, we know of no reports of the effect of radiation to the skin on indices of injury secondary to irradiation to the thorax.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced survival from radiation pneumonitis by combined irradiation to the skin

Gao¹,

Fish²,

Szabó³

et al. 2014

International Journal of Radiation Biology

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Purpose To develop mitigators for combined irradiation to the lung and skin. Methods Rats were treated with X-rays as follows: (1) 12.5 or 13 Gy whole thorax irradiation (WTI) (2) 30 Gy soft X-rays to 10% area of the skin only (3) 12.5 or 13 Gy WTI+30 Gy skin irradiation after 3 hours (4) 12.5 Gy WTI+skin irradiation and treated with captopril (160 mg/m2/day) started after 7 days. Our end points were survival (primary) based on IACUC euthanization criteria and secondary measurements of breathing intervals and skin injury. Lung collagen at 210 days was measured in rats surviving 13 Gy WTI. Results After 12.5 Gy WTI with or without skin irradiation, one rat (12.5 Gy WTI) was euthanized. Survival was less than 10% in rats receiving 13 Gy WTI, but was enhanced when combined with skin irradiation (p<0.0001). Collagen content increased at 210 days after 13 Gy WTI vs 13 Gy WTI+30 Gy skin irradiation (p<0.05). Captopril improved radiation-dermatitis after 12.5 Gy WTI+30 Gy skin irradiation (p=0.008). Conclusions Radiation to the skin given 3 hours after WTI mitigated morbidity during pneumonitis in rats. Captopril enhanced the rate of healing of radiation-dermatitis after combined irradiations to the thorax and skin.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Enhanced survival from radiation pneumonitis by combined irradiation to the skin

Gao¹,

Fish²,

Szabó³

et al. 2014

International Journal of Radiation Biology

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“…In wound healing and plastic surgery, this difference in mononuclear cell function has been exploited; activated macrophages from young humans are used in the treatment of chronic ulcers in elderly humans [34]. Importantly, just as EPCs are mobilized after myocardial infarction, wound trauma also mobilizes hematopoietic cells [188] and EPC transplantation acceler- Fig. (2).…”

Section: Oxygen Wounds and Myocardial Infarc-tion: A Concluding Analogymentioning

confidence: 99%

Hypoxia Inducible Factor-1α, Endothelial Progenitor Cells, Monocytes,Cardiovascular Risk, Wound Healing, Cobalt and Hydralazine:A Unifying Hypothesis

Hoenig¹,

Bianchi²,

Sellke

2008

CDT

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Bone marrow-derived mononuclear cells differentiate into endothelial cells in adult animals, including humans. These cells, endothelial progenitor cells (EPCs), play central roles in neovascularization in a variety of physiological and pathological processes. EPCs numbers are clinically relevant; in patients with vascular disease, EPC numbers are predictive of hard clinical endpoints and correlate with vascular health in patients without manifest atherosclerosis. EPCs express CXCR4 which allows homing to sites of neovascularization. The homing signal released by the target tissues is SDF-1 which is the ligand for CXCR4. With release of SDF-1 and reversal of the marrow/periphery gradient, EPCs are mobilized to the periphery where they are recruited to SDF-1 expressing tissues. The SDF-1/CXCR4 axis is the final common pathway for EPC mobilization by hypoxia, angiogenic peptides and G-CSF. Expression of SDF-1 in target tissues and CXCR4 in EPCs as well as angiogenic cytokines such as VEGF are regulated by hypoxia inducible factor-1 alpha (HIF-1 alpha). This paper discusses evidence suggesting that depressed HIF-1 alpha-mediated gene programming is the most fundamental of all cardiovascular risk factors and discusses the manipulation of this system with existing drugs such as cobalt or hydralazine. By stabilizing HIF-1 alpha protein, these compounds will enhance EPC mobilization and function, thereby improving cardiovascular health overall. This paper discusses why previous studies with EPC transplantation or mobilization with G-CSF have had negative results and proposes the use of Cobalt and Hydralazine to enhance EPC function to overcome the dysfunctional EPC phenotype that is seen in patients with vascular disease or cardiovascular risk factors.

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“…Stem cell (SC) mobilization from the bone marrow to acutely injured tissue significantly enhancing wound healing was first observed in a mouse skin-wound model 6 . Large animal models demonstrated that SC therapy produces significant improvements in AMI 7,8 , leading to clinical trials for SC therapy in patients with AMI and heart failure.…”

Section: Introductionmentioning

confidence: 99%

What Is the Future of Cell-Based Therapy for Acute Myocardial Infarction

Tompkins

Natsumeda

Balkan

et al. 2017

Circulation Research

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Hematopoietic colony-forming cells from mice after wound trauma

Cited by 17 publications

References 16 publications

Enhanced survival from radiation pneumonitis by combined irradiation to the skin

Enhanced survival from radiation pneumonitis by combined irradiation to the skin

Hypoxia Inducible Factor-1α, Endothelial Progenitor Cells, Monocytes,Cardiovascular Risk, Wound Healing, Cobalt and Hydralazine:A Unifying Hypothesis

What Is the Future of Cell-Based Therapy for Acute Myocardial Infarction

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Hematopoietic colony-forming cells from mice after wound trauma

Cited by 17 publications

References 16 publications

Enhanced survival from radiation pneumonitis by combined irradiation to the skin

Enhanced survival from radiation pneumonitis by combined irradiation to the skin

Hypoxia Inducible Factor-1&#945;, Endothelial Progenitor Cells, Monocytes,Cardiovascular Risk, Wound Healing, Cobalt and Hydralazine:A Unifying Hypothesis

What Is the Future of Cell-Based Therapy for Acute Myocardial Infarction

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Product

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Hypoxia Inducible Factor-1α, Endothelial Progenitor Cells, Monocytes,Cardiovascular Risk, Wound Healing, Cobalt and Hydralazine:A Unifying Hypothesis