1991
DOI: 10.1128/mcb.11.5.2391
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Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.

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Cited by 145 publications
(89 citation statements)
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References 36 publications
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“…As an Src kinase member mainly expressed in B and myeloid lineages (Yi et al, 1991), it is plausible that Lyn phosphorylates and activates STAT in a JAK-independent manner. In support of this hypothesis, Lyn plays a role in erythropoietin-induced tyrosine phosphorylation of STAT5 (Okutani et al, 2001).…”
Section: Discussionmentioning
confidence: 99%
“…As an Src kinase member mainly expressed in B and myeloid lineages (Yi et al, 1991), it is plausible that Lyn phosphorylates and activates STAT in a JAK-independent manner. In support of this hypothesis, Lyn plays a role in erythropoietin-induced tyrosine phosphorylation of STAT5 (Okutani et al, 2001).…”
Section: Discussionmentioning
confidence: 99%
“…Expression plasmids for various CrkL mutants were described previously (16). Expression plasmids for alternatively spliced isoforms of murine Lyn (pXM-LynA and pXM-LynB) have been described previously (5,23). An expression plasmid for a Lyn mutant (pXM-LynAN) in which a C-terminal half-portion of the kinase domain (amino acids 397-512) is deleted was constructed by introducing a stop codon by the polymerase chain reaction method, as described previously (5).…”
Section: Methodsmentioning
confidence: 99%
“…Concerning Lyn, the cDNA used in this experiment corresponds to the 56 kDa isoform of the kinase. Indeed, two isoforms of Lyn, p53 and p56 Lyn have been described that dier only in a short 21 amino-acids sequence located in the unique N-terminal region (Yi et al, 1991 …”
Section: Cleavage Of Src Kinases By Caspase 3 In Vitromentioning
confidence: 99%