Hematopoetic stem cell transplantation in children

Yeşilipek, M. Akif

doi:10.5152/tpa.2014.2010

Cited by 32 publications

(31 citation statements)

References 66 publications

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“…Although the alternations in blood proteome have already been extensively described, the lipid alternations in the course of HSCT remain unclear [14][15][16][17][18]. The analysis of our patients presented in this paper revealed some regularities in the lipid metabolism during the course of…”

Section: Discussionmentioning

confidence: 73%

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Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients

et al. 2020

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HSCT (hematopoietic stem cell transplantation) is a widely applied method of treatment of pediatric patients with leukemia and other bone marrow-associated disorders. Metabolic disturbances can appear as procedure side effects. This study aimed to report incidence of lipid and thyroid disorders and time of their onset in pediatric patients after HSCT. There were 198 pediatric patients (123 males) aged 0.5–20 years who were subjected to HSCT. Patients were mostly diagnosed with Acute Leukemia (n = 190). The analysis of lipids, thyroid hormones, and thyroid antibodies levels comprised one month before the HSCT to last follow up visit between 2016 and 2019 (median 3.8 ± 1.8 years after HSCT). In males, the triglycerides levels increased over two times in the course of HSCT in both patients with initially low and elevated HDL (high-density lipoprotein) levels. Most of the lipid disorders occurred in six months after HSCT. Patients treated with L-thyroxine exhibited decreased LDL (low-density lipoprotein) levels. HDL remained at a lower level in males. Thyroid hormone abnormalities were evenly distributed in time until 4 years after HSCT. Patients require long term follow up including lipid metabolism and thyroid function analysis. HSCT survivors demand introduction of polyunsaturated fatty acids into the diet to reduce risk of developing the lipid complications.

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Section: Discussionmentioning

confidence: 73%

“…The iatrogenic deprivation of patient homeostasis rises the success rate for the lack of rejection and relapses, but also leads to severe complications [4]. Besides, pediatric HSCT recipients, especially with malignant hematologic disorders, are one of the most abundant groups due to size of the population [17].…”

Section: Introductionmentioning

confidence: 99%

Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients

et al. 2020

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“…Bone marrow transplantation (BMT) is used to treat many diseases including immune deficiency, hemoglobinopathy, congenital metabolic disease and bone marrow failure in addition to hematological malignancy in children. 1 While it can be lifesaving, the process involves preparatory regimens of chemotherapy and/or radiation, prolonged and socially isolated hospital stays and a high risk of death and other medical complications, such as graft-versus-host disease (GVHD) and infection following the transplant. Children may also experience long-term effects such as social and academic problems, infertility, late medical effects, increased risk of secondary malignancy and potential disease recurrence.…”

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confidence: 99%

Psychopathology in pediatric bone marrow transplantation survivors and their mothers

Adanır

Taşkıran

Küpesiz

et al. 2017

Pediatrics International

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“…In children, bone marrow transplantation is used as a definite treatment in many benign and malign disorders . In 1965, hematopoietic progenitor cells were reproduced in the semisolid culture medium for the first time and were designed as CFU .…”

Section: Introductionmentioning

confidence: 99%

Effects of iron and vitamin B12 deficiencies on peripheral blood colony‐forming unit capacity

Zabun

Köksal

Çelik

et al. 2018

Pediatric Transplantation

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Iron and vitamin B12 deficiencies are two of the most common diseases in the childhood group. Deficiencies of iron and vitamin B12 affect many systems in the body. In this study, to discover the effects of iron and vitamin B12 deficiencies on the hematopoietic stem cells, we studied CFU assay from peripheral blood. One hundred and two children were included in our study and were evaluated in five categories: iron deficiency, iron deficiency anemia, vitamin B12 deficiency, iron and vitamin B12 deficiency, and controls. As a result of statistical analysis, no significant difference was detected between five groups in terms of CFU assays. The results of our study suggest that, in emergent situations, stem cell samples can be collected before treatment with B12 or iron which are common deficiencies in donors of hematopoietic stem cell transplantation. We conclude that we could reach more accurate results by designing a study which contains more patients and includes in vivo results.

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Hematopoetic stem cell transplantation in children

Cited by 32 publications

References 66 publications

Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients

Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients

Psychopathology in pediatric bone marrow transplantation survivors and their mothers

Effects of iron and vitamin B12 deficiencies on peripheral blood colony‐forming unit capacity

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