Toxins and Hemostasis 2010
DOI: 10.1007/978-90-481-9295-3_14
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Hematophagy and Inhibition of the Extrinsic and Intrinsic Tenase Complexes

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Cited by 2 publications
(3 citation statements)
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“…We further demonstrated that ixolaris blocks PAR2-mediated signalling in human breast tumour cells, thus accounting for the reduced production of pro-tumoural molecules [129]. NAPc2 is a TF/FVIIa inhibitor characterized from the haematophagous nematode Ancylostoma caninum [130]. It displays an anticoagulant mechanism of action that is similar to ixolaris and it inhibits primary tumour growth and metastasis in animal models [131].…”
Section: Therapies Targeting Blood Coagulation-related Proteinsmentioning
confidence: 99%
“…We further demonstrated that ixolaris blocks PAR2-mediated signalling in human breast tumour cells, thus accounting for the reduced production of pro-tumoural molecules [129]. NAPc2 is a TF/FVIIa inhibitor characterized from the haematophagous nematode Ancylostoma caninum [130]. It displays an anticoagulant mechanism of action that is similar to ixolaris and it inhibits primary tumour growth and metastasis in animal models [131].…”
Section: Therapies Targeting Blood Coagulation-related Proteinsmentioning
confidence: 99%
“…The FIX/ FIXa binding occurs through its B-C and E-F strands as well as its C-terminus [94]. (For details, see [91]).…”
Section: Intrinsic Tenase Complex Inhibitorsmentioning
confidence: 99%
“…In contrast, AceAP1 uses FXa as a scaffold by binding to both its active site and exosite, and forms a quaternary complex with the FVIIa‐TF complex [87,88]. (For details, see [91]).…”
Section: Anticoagulant Proteins From Haematophagous Animalsmentioning
confidence: 99%