Hematophagy and Inhibition of Platelet Aggregation

Francischetti, Ivo M.B.

doi:10.1007/978-90-481-9295-3_20

Cited by 1 publication

(2 citation statements)

References 81 publications

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“…They hydrolyze ATP and ADP into AMP and P i, thus inhibiting platelet aggregation [64]. Three classes of apyrases have been characterized from different blood‐sucking arthropods (for details, see [95]).…”

Section: Antiplatelet Proteins From Haematophagous Animalsmentioning

confidence: 99%

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Toxins in thrombosis and haemostasis: potential beyond imagination

Kini

2011

Journal of Thrombosis and Haemostasis

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Summary. Exogenous factors isolated from venoms of snakes and saliva of haematophagous animals that affect thrombosis and haemostasis have contributed significantly to the development of diagnostic agents, research tools and life-saving drugs. Here, I discuss recent advances in the discovery, structural and functional characterisation, and mechanism of action of new procoagulant and anti-haemostatic proteins. In nature, these factors have evolved to target crucial ÔbottlenecksÕ in the coagulation cascade and platelet aggregation. Several simple protein scaffolds are used to target a wide variety of target proteins and receptors exhibiting functional divergence. Different protein scaffolds have also evolved to target identical, physiologically relevant key enzymes or receptors exhibiting functional convergence. At times, exogenous factors bind to the same target protein, but at distinct sites, to differentially attenuate their functions exhibiting mechanistic divergence within the same family of proteins. The structure-function relationships of these factors are subtle and complicated but represent an exciting challenge. These studies provide ample opportunities to design highly specific and precise ligands to achieve desired biological target function. Although only a small number of them have been characterised to date, the molecular and mechanical diversities of these exogenous factors and their contributions to understanding molecular and cellular events in thrombosis and haemostasis as well as developing diagnostic and research tools and therapeutic agents, is outstanding. Based on the current status, I have attempted to identify future potential and prospects in this area of research.

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Section: Antiplatelet Proteins From Haematophagous Animalsmentioning

confidence: 99%

“…It is not clear whether they are ADP‐ or TXA2‐binding proteins. Amine‐binding protein, D7, monotonin, TSGP‐1 and SHBP bind to epinephrine and serotonin with high affinity, and all are lipocalins with varied affinity for distinct ligands (For details, see [95]).…”

Section: Antiplatelet Proteins From Haematophagous Animalsmentioning

confidence: 99%

Toxins in thrombosis and haemostasis: potential beyond imagination

Kini

2011

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

show abstract

Hematophagy and Inhibition of Platelet Aggregation

Cited by 1 publication

References 81 publications

Toxins in thrombosis and haemostasis: potential beyond imagination

Toxins in thrombosis and haemostasis: potential beyond imagination

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