Hematology of the Domestic Ferret (Mustela putorius furo)

Smith, Stephen A.; Zimmerman, Kurt; Moore, David

doi:10.1016/j.cll.2015.05.009

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…As thrombocytopenia is one of its major clinical symptoms, we collected blood from SFTSV CB1/2014-infected young adult and aged ferrets and compared their homeostasis factors. Our results showed that the mean platelet count of SFTSV-infected young adult ferrets was normal, although it fell to baseline at 6 dpi and returned to the normal range (171.7–1,280.6 × 10 3 per μ1) 23,24 at 8 dpi (Fig. 2a).…”

Section: Resultsmentioning

confidence: 64%

“…Platelet counts from young adult ferrets ( a ), platelet counts from aged ferrets ( b ), WBC counts from young adult ferrets ( c ) and WBC counts from aged ferrets ( d ) are shown. Normal ranges of platelet and WBC counts in ferrets are 171.7–1,280.6×10 3 per μl and 2.5–16.7 × 10 6 per μl, respectively 23,24 . The dashed lines indicate the normal values of platelet or WBC counts.…”

Section: Fig 1 |mentioning

confidence: 99%

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Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis

et al. 2018

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Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the most dangerous pathogens by the World Health Organization, has 12–30% fatality rates with a characteristic thrombocytopenia syndrome. With a majority of clinically diagnosed SFTSV patients older than ~50 years of age, age is a critical risk factor for SFTSV morbidity and mortality. Here, we report an age-dependent ferret model of SFTSV infection and pathogenesis that fully recapitulates the clinical manifestations of human infections. Whereas young adult ferrets (≤2 years of age) did not show any clinical symptoms and mortality, SFTSV-infected aged ferrets (≥4 years of age) demonstrated severe thrombocytopenia, reduced white blood cell counts and high fever with 93% mortality rate. Moreover, a significantly higher viral load was observed in aged ferrets. Transcriptome analysis of SFTSV-infected young ferrets revealed strong interferon-mediated anti-viral signalling, whereas inflammatory immune responses were markedly upregulated and persisted in aged ferrets. Thus, this immunocompetent age-dependent ferret model should be useful for anti-SFTSV therapy and vaccine development.

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Section: Resultsmentioning

confidence: 64%

Section: Fig 1 |mentioning

confidence: 99%

Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis

et al. 2018

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“…2015) and the polarity‐specific domains that respond to luminance increments or decrements in the full‐field are revealed in the superficial layers of ferret V1 (Smith et al. ). The luminance domains have been identified in V2 of cats and monkeys (Tani et al.…”

Section: Discussionmentioning

confidence: 99%

Neurons in primary visual cortex represent distribution of luminance

Wang

2016

Physiol Rep

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To efficiently detect a wide range of light‐intensity changes, visual neurons must adapt to ambient luminance. However, how neurons in the primary visual cortex (V1) code the distribution of luminance remains unknown. We designed stimuli that represent rapid changes in luminance under different luminance distributions and investigated V1 neuron responses to these novel stimuli. We demonstrate that V1 neurons represent luminance changes by dynamically adjusting their responses when the luminance distribution changes. Many cells (35%) detected luminance changes by responding to dark stimuli when the distribution was dominated by bright stimuli, bright stimuli when dominated by dark stimuli, and both dark and bright stimuli when dominated by intermediate luminance stimuli; 13% of cells signaled the mean luminance that was varied with different distributions; the remaining 52% of cells gradually shifted the responses that were most sensitive to luminance changes when the luminance distribution varied. The remarkable response changes of the former two cell groups suggest their crucial roles in detecting luminance changes. These response characteristics demonstrate that V1 neurons are not only sensitive to luminance change, but also luminance distribution change. They encode luminance changes according to the luminance distribution. Mean cells represent the prevailing luminance and reversal cells represent the salient stimuli in the environment.

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Blood Transfusion in Exotic Species

Strunk¹,

Stöhr²

2022

Schalm's Veterinary Hematology

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Hematology of the Domestic Ferret (Mustela putorius furo)

Cited by 6 publications

References 20 publications

Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis

Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis

Neurons in primary visual cortex represent distribution of luminance

Blood Transfusion in Exotic Species

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