Hematology

MacNeill, Amy L.

doi:10.1002/9781119421351.ch2

Cited by 1 publication

(4 citation statements)

References 7 publications

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“…The determination of PCV utilized the micro haematocrit method described by Thrall & Weiser (2002) and Coles (1986). The capillary tubes were filled with blood samples up to three-quarters full through capillary action.…”

Section: Determination Of Packed Cell Volume (Pcv)mentioning

confidence: 99%

“…The count of red blood cells was performed using the haemocytometer method, as described by Thrall & Weiser (2002) and Coles. A micropipette was used to draw 0.02 ml of the blood sample, which was then mixed with 4 ml of erythrocyte-diluting fluid in a test tube.…”

Section: Red Blood Cell Countmentioning

confidence: 99%

“…The count of white blood cells was conducted using the haemocytometer method described by Thrall & Weiser (2002) and Coles. Similarly, 0.02 ml of the blood sample was drawn using a micropipette and mixed with 0.4 ml of white blood cell diluting fluid in a test tube.…”

Section: Total White Blood Cell Countmentioning

confidence: 99%

“…The differential count of white blood cells was performed using the Leishmann technique as described by Thrall & Weiser (2002). A drop of blood was gently shaken and carefully smeared on a clean grease-free slide using a cover slip, creating a thin smear.…”

Section: Differential White Blood Cell Countmentioning

confidence: 99%

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Evaluation of Short-Term Effects of Anti-Malaria Drugs on Haematology and Serum Electrolytes in Rats

2023

ALST

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The study investigated the short-term effects of artemether-lumefantrine and chloroquine on haematology and serum electrolytes profile in albino rats. Sixty adult male albino rats, 12-13 weeks of age, weighing 156 -179 g were procured and used for this study. The rats were assigned into five groups of twelve rats per group replicated 3 times (4 rats per replicate). The groups were: 1. control group (CONTL GRP), 2. high dose artemether Lumefantrine (HD ARTEM LUMF. 4/24 mg/ml), 3. low dose artemether-lumefantrine (LD ARTEM LUMF. 2/12 mg/ml), 4. high dose chloroquine (HD CHLQN. 20 mg/ml) and 5. low dose chloroquine (LD CHLQN. 10 mg/ml)). Rats in the Control group were administered an equivalent volume of placebo (distilled water) according to body weight. Treatment was done daily and lasted for 3 days. The administration was orally using plastic syringes attached to a metal oropharyngeal cannula. Both 4/24 mg/ml and 2/12 mg/ml doses of artemether-lumefantrine showed a non-significant effect (p > 0.05) in WBC, Neu, Lym, Mon, Eos, Bas, RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV, RDW-SD, PLT, MPV, and PDW except in PCT where low (2/12 mg/ml) dose caused a significant increase (p < 0.05) compared with the control. Artemether-lumefantrine and chloroquine had similar effects on K, Na, Cl, iCa, TiCa, TCa, pH, TCO2, and AG. Both high (4/24 mg/ml) and low (2/12 mg/ml) doses of artemether-lumefantrine showed no significant effect (p > 0.05) on K, Na, Cl, iCa, TiCa, TCa, pH, TCO2, and AG but Cl showed a significant increase (p<0.05) compared with the control. Chloroquine doses (20 mg/ml & 10 mg/ml) had similar effects except on Cl where the high dose (20 mg/ml) caused a significant increase (p<0.05) as compared with the control. However, the significant increase in Cl could depict dehydration.

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Section: Determination Of Packed Cell Volume (Pcv)mentioning

confidence: 99%

Section: Red Blood Cell Countmentioning

confidence: 99%

Section: Total White Blood Cell Countmentioning

confidence: 99%

Section: Differential White Blood Cell Countmentioning

confidence: 99%

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