Hematological reference values of healthy Malaysian population

Abstract

Health and disease can only be distinguished by accurate and reliable reference values of a particular laboratory test. It is now a proven fact that there is considerable variation in hematology reference intervals depending on the demographic and preanalytical variables. There are evidences that values provided by manufacturers do not have appropriate application for all populations. Moreover, reference ranges provided by different laboratory manuals and books also do not solve this problem. We are presenting here normal reference ranges of Malaysian population. These values were determined by using Sysmex XE-2100 and ACL 9000 hematology and coagulation analyzers. Results from this study showed that there were considerable differences in the reference values from manufacturers, western population or laboratory manuals compared with those from the local population.

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

“…Many studies that have previously established hematology reference intervals have been based on small sample sizes. For example, Roshan et al used 110 adults for calculation of monocyte count reference intervals, and although sex differences were observed, none were statistically significant (31 ). In the present study, Ͼ1000 adults were included, which invariably improves the study power and thus enables determination of statistical differences between even very subtle sex-or age-related changes.…”

Full blood count normal reference values for adults in France

“…Given the French ban on entering the ethnic origin of an individual into an electronic database, it is impossible to present the biological variation related to ethnic origin, despite the multiethnic nature of the French population. Modifications in white cells and neutrophils count in subjects of African ancestry are known 11 12. The questionnaire used for the PHA does not take into consideration exposure to environmental factors, pesticides, radiation, electromagnetic waves or genetic factors liable to modify certain haematological factors.…”

Characteristics of the Main Indicators of Peripheral Blood in Adolescents in the Tomsk Region

“…При этом уровень моноцитов и эозинофилов превышал соответствующие значения в сравнении с аналогичными показателями в западных странах. Наряду с этим выявлены существен-ные различия значений гематологических показате-лей разных субпопуляций жителей Африки, связанные с климатом, областью проживания, этнической принад-лежностью [8][9][10]. По результатам ряда исследований, проведенных в странах Азии, также получены данные, указывающие на более низкие референсные значения показателей периферической крови в сравнении с нор-мами, принятыми в западных странах [6,9,11].…”

“…Среднее количество лейкоцитов, определенное в нашем исследовании, было ниже референсных значений, указанных в националь-ном и международном стандарте, но при этом получен-ные данные были сопоставимы с результатами большин-ства отечественных исследований, а также данными, опубликованными некоторыми зарубежными авторами [6,9,14]. Более высокие показатели уровня эритроцитов и гемоглобина имели юноши, в то время как у деву-шек был зарегистрирован высокий уровень лейкоцитов и СОЭ.…”