Hematological Reference Values for Healthy Adults in Togo

Abstract

The hematological reference values are very important for diagnostic orientation and treatment decision. The aim of this study was to establish hematological reference values for healthy adults in Togo. A total of 2571 voluntary blood donors participated to this study. Only 1349 subjects negative for HIV, HBV, HCV, malaria, and without hemoglobin abnormalities in electrophoresis and hypochromia on blood smear, were definitively retained for the study. Median hemoglobin level was higher in males than females (15.1 g/dL versus 13.0 g/dL, p = 0.000). Median total WBC (4.2×109/L) and absolute neutrophil counts (1.6×109/L) were similar by gender. The median lymphocyte counts in males and females were, respectively, 2.1×109/L and 2.2×109/L (p = 0.11). The median platelet count was lower in males than females (236×109/L versus 247×109/L, p = 0.004). Our median values for RBC parameters differ from those of African countries probably because of our inclusion criteria which eliminate most cases with iron deficiency and/or thalassemia.

Hematological reference intervals determination in adults at Gondar university hospital, Northwest Ethiopia

“…While there was no significant differences between genders with regard to WBC parameters, platelet counts, ESR, MCV and RDW. This was also in agreement with previously carried out studies in Addis Ababa and other African countries [1, 6, 15, 17–19] (Tables 4, 5 and 6). The significant difference between male and female may be due to biological and physiological factors such as the influence of the hormone androgen on erythropoiesis and also due to menstrual blood loss in females…”

The largest reference range study for hematological parameters from Turkey: A case control study

“…MCV reference ranges for men and women were nearly below the defined cutoff values for anemia. It can be hypothesized that the low minimal range MCV, which contrasts with the normal RBC, may be linked to the presence of undefined anemia [20]. This study illustrated the difficulty in obtaining reference values from healthy individuals for reference values for RBC series, despite detailed medical examination.…”

Comparison of Routine Hematology Results Based on Local Laboratory Reference Value and Sysmex Kx-21 Reference Value in Hasan Sadikin Hospital Bandung

“…Rentang nilai rujukan hematologi yang umumnya digunakan sekarang ini adalah berdasarkan rentang nilai rujukan yang berasal dari populasi orang Kaukasia misalnya yang terdapat pada buku teks hematologi Wintrobe juga dapat dibuat berdasarkan penelitian yang dikeluarkan oleh produsen alat hematologi (Sysmex, 2004). [1][2][3][4][5] Populasi manusia beragam-ragam sehingga ada kemungkinan rentang nilai rujukan untuk populasi tertentu akan berbeda dengan populasi lainnya. Hal ini kemungkinan disebabkan oleh adanya perbedaan jenis kelamin, ras, lingkungan, tingkat sosial, ekonomi, dan budaya di populasi tertentu.…”

“…Salah satu kendala dalam menetapkan nilai nilai rujukan hematologi di Indonesia adalah tingginya angka defisiensi besi, infeksi parasit, virus, dan mungkin thalassemia. 1,6,7 Parameter-parameter eritrosit dipengaruhi oleh beberapa faktor terutama kelainan sintesis hemoglobin. Kelainan-kelainan ini dapat berupa kelainan kongenital seperti anemia bulan sabit dan thalassemia atau kelainan didapat seperti anemia defisiensi besi.…”