Hematological Profile of Hb Adana Among High School Students in Northeast Peninsular Malaysia
Mat Jusoh Siti Asmaa,
Lee Miin Phoon,
Nur Atikah Zakaria
et al.
Abstract:Background
Hb Adana is a non-deletional alpha (α)-thalassaemia variant resulting from mutations in α1- or α2-globin codon 59 (α
CD59
), leading to the production of unstable α-globin. Clinical manifestations can vary from silent carrier status to dependence on blood transfusions, hepatosplenomegaly, skeletal deformities, and spinal cord compression. Despite the significance of Hb Adana inheritance, studying this variant poses challenges due to the scarcity of molecular tests a… Show more
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