Hematological profile and biochemical markers of COVID-19 non-survivors: A retrospective analysis

Bairwa, Mukesh; Kumar, Rajesh; Beniwal, Kalpana; Kalita, Deepjyoti; Bahurupi, Yogesh

doi:10.1016/j.cegh.2021.100770

Cited by 36 publications

(46 citation statements)

References 23 publications

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“…Our results show a male to female predominance in terms of hospital admission, having a median age of 60 years, results comparable to other already published [ 3 , 51 – 53 ]. The biochemical analysis from our cohorts showed the typical spectrum of hematological alterations, including leukocytosis with neutrophilia and lymphopenia, increased values of plasma ferritin, LDH, CRP, and abnormal platelet count and procalcitonin levels as evidenced in most patients elsewhere [ 54 – 58 ].…”

Section: Discussionmentioning

confidence: 85%

High-altitude is associated with better short-term survival in critically ill COVID-19 patients admitted to the ICU

Simbaña-Rivera

Jaramillo²,

Silva

et al. 2022

PLoS ONE

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Background Multiple studies have attempted to elucidate the relationship between chronic hypoxia and SARS-CoV-2 infection. It seems that high-altitude is associated with lower COVID-19 related mortality and incidence rates; nevertheless, all the data came from observational studies, being this the first one looking into prospectively collected clinical data from severely ill patients residing at two significantly different altitudes. Methods A prospective cohort, a two-center study among COVID-19 confirmed adult patients admitted to a low (sea level) and high-altitude (2,850 m) ICU unit in Ecuador was conducted. Two hundred and thirty confirmed patients were enrolled from March 15th to July 15th, 2020. Results From 230 patients, 149 were men (64.8%) and 81 women (35.2%). The median age of all the patients was 60 years, and at least 105 (45.7%) of patients had at least one underlying comorbidity, including hypertension (33.5%), diabetes (16.5%), and chronic kidney failure (5.7%). The APACHE II scale (Score that estimates ICU mortality) at 72 hours was especially higher in the low altitude group with a median of 18 points (IQR: 9.5–24.0), compared to 9 points (IQR: 5.0–22.0) obtained in the high-altitude group. There is evidence of a difference in survival in favor of the high-altitude group (p = 0.006), the median survival being 39 days, compared to 21 days in the low altitude group. Conclusion There has been a substantial improvement in survival amongst people admitted to the high-altitude ICU. Residing at high-altitudes was associated with improved survival, especially among patients with no comorbidities. COVID-19 patients admitted to the high-altitude ICU unit have improved severity-of-disease classification system scores at 72 hours.

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Section: Discussionmentioning

confidence: 85%

High-altitude is associated with better short-term survival in critically ill COVID-19 patients admitted to the ICU

Simbaña-Rivera

Jaramillo²,

Silva

et al. 2022

PLoS ONE

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“…Many biochemical parameters are altered in COVID-19 patients, which correlates with disease severity ( 19 – 22 ). The biochemical parameters with increased levels in these severe COVID-19 patients include alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), bilirubin, urea, creatine, amylase, lipase, procalcitonin, C-reactive protein (CRP), D-dimer, and lactate dehydrogenase (LDH).…”

Section: Discussionmentioning

confidence: 99%

“…SARS-CoV-2 has been confirmed in animals and humans and can cause dysfunction of various organs, including the lungs ( 11 , 13 , 19 ). Abnormal liver function was a significant observation in patients with COVID-19 ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19

et al. 2022

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“…In addition, diagnostic and prognostic risk scores such as the National Early Warning Score 2 (NEWS 2) and 4C mortality score for COVID-19 are accessible and they all demonstrated have excellent discriminative performance. [36][37][38] However, our predictors did not include clinical characteristics, such as dyspnea and unconsciousness, mainly because of lacking of availability in a retrospective context.…”

Section: Discussionmentioning

confidence: 99%

Hematological features and risk factors of hospitalized COVID-19 patients: A retrospective analysis

Hua

Yang

et al. 2022

Eur J Inflamm

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Background: Coronavirus disease 2019 (COVID-19) became pandemic in 2020 and recently, mutated coronaviruses have emerged in many countries. The aim of this study was to identify the clinical characteristics and risk factors for critical illness in hospitalized COVID-19 patients in Zhengzhou for clinical prevention and management. Materials and methods: A total of 70 patients hospitalized with COVID-19 were enrolled between 21 January and 29 February 2020, in Zhengzhou, China. Clinical characteristics, hematological findings, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and inflammatory index on admission were obtained from medical records, COVID-19 patients with different outcomes were compared. Results: The median age was 55 years. Forty-three (61.0%) patients were classified as having severe or critical cases. Eighteen (25.7%) patients died in hospital and the remaining 52 were discharged. Patients who died tend to be old with expectoration and chronic obstructive pulmonary disease. Compared to survivor, non-survivor had significantly higher numbers of leucocytes and neutrophils, NLR, aspartate aminotransferase (AST), γ-glutamyl transpeptidase, total bilirubin, direct bilirubin, lactate dehydrogenase (LDH), prothrombin time, D-dimer, C-reactive protein, and decreased platelets, lymphocytes, uric acid, and albumin (ALB). Logistic regression analysis identified leucocytes, platelets, PLR, NLR, AST, and ALB as independent predictive factors for poor outcomes. The area under curve of the combination of leucocytes, PLR, NLR, and AST was 0.87, with a sensitivity of 0.83 and specificity of 0.81. Conclusion: Our results identified risk factors among COVID-19 patients for in-hospital mortality. Leucocytes, PLR, NLR, and AST could have important reference value for predicting prognosis, especially in low-resource countries.

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Hematological profile and biochemical markers of COVID-19 non-survivors: A retrospective analysis

Cited by 36 publications

References 23 publications

High-altitude is associated with better short-term survival in critically ill COVID-19 patients admitted to the ICU

High-altitude is associated with better short-term survival in critically ill COVID-19 patients admitted to the ICU

Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19

Hematological features and risk factors of hospitalized COVID-19 patients: A retrospective analysis

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