Hematological Observations on Bone Marrow Obtained by Sternal Puncture

Vogel, Peter; Erf, Lowell A.; Rosenthal, Nathan

doi:10.1093/ajcp/7.5.436

Cited by 55 publications

(12 citation statements)

References 10 publications

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“…Those patients unrespon¬ sive to corticosteroid therapy must not be considered hopeless. Although transfusions are necessary in these children every [3][4][5][6][7][8] weeks, the possibility always exists that a spontaneous remission will occur. Six $ of our 18 patients had a spontaneous remission, 1 of these occurring after 13 years of trans¬ fusion therapy.…”

Section: Commentmentioning

confidence: 99%

“…There was a total of 84 pregnancies resulting in 33 children with congenital hypoplastic anemia, 8 abortions, 3 stillbirths, 1 therapeutic abortion, and 39 children living and well. This number of abortions corresponds with the estimated 10% incidence for all pregnancies mentioned by Eastman.17 Only one of the families had known consanguin¬ ity, and, in this case, the parents of the affected child are first cousins, as are the grandparents.…”

Section: Introductionmentioning

confidence: 99%

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Congenital (Erythroid) Hypoplastic Anemia

Diamond¹

1961

Am J Dis Child

147

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Section: Commentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Congenital (Erythroid) Hypoplastic Anemia

Diamond¹

1961

Am J Dis Child

147

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“…Hematogones (B-lymphocyte precursors), originally recognized by their morphologic features in bone marrow smears, 1,2 are found in small numbers in most marrow specimens analyzed by flow cytometry. They are reported to occur in large numbers in some healthy infants and young children and in a variety of diseases in both children and adults.…”

Section: Introductionmentioning

confidence: 99%

Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry

McKenna

Washington

Aquino

et al. 2001

Blood

338

281

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Bone marrow hematogones (B-lymphocyte precursors) may cause problems in diagnosis because of their morphologic and immunophenotypic similarities to neoplastic lymphoblasts. The purposes of this prospective, multiparametric flow cytometry study were to quantify hematogones across age groups and a spectrum of clinical conditions, to identify factors that affect the relative quantity of hematogones, and to compare their immunophenotype with that of neoplastic lymphoblasts. A total of 662 consecutive marrow specimens were analyzed for hematogones using one of two 4-color antibody combinations; hematogones were identified in 528 (79.8%). There was a significant decline in hematogones with increasing age (P < .001), but a broad range was found at all ages and many adults had a relatively high number. Specimens processed by density gradient had a higher mean percent hematogones than those processed by erythrocyte lysis (P < .001). There was a direct decline in hematogones with increasing marrow involvement with neoplastic cells. A total of 8% of the 662 specimens contained 5% or more hematogones: 24.6% of specimens from patients aged less than 16 years and 6.3% from those 16 and older (P < .000 01).

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“…They were first described and named hematogones in 1937 [4]. They are immature-appearing lymphoid cells with a very high nuclear-to-cytoplasmic ratio, have round to slightly irregular nuclei, and are occasionally clefted or folded with a dense homogeneous chromatin without nucleoli or inconspicuous nucleoli and scant agranular cytoplasm [4 -6].…”

Section: Discussionmentioning

confidence: 99%

Expression of CD5 on Hematogones in a 7-Year-old Girl with Shwachman-Diamond Syndrome

Jelić

Raj

Jin

et al. 2001

Pediatric and Developmental Pathology

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We report increased numbers of hematogones in a 7-year-old girl with pancytopenia due to Shwachman-Diamond syndrome. Her hematogones expressed the T-cell marker CD5 as well as CD19, CD10, and CD20, and terminal deoxynucleotidyl transferase and HLA-DR. These findings suggest that hematogones are precursors of both CD5-positive B cells and CD5-negative B cells. Thus CD5-positive B cells in bone marrow may be derived from bone marrow stem cells, and not from the residual fetal B cells of yolk sac/liver origin. The finding of CD5 expression on hematogones also raises the possibility that neoplastic B cells of chronic lymphocytic leukemia, which characteristically co-express CD5 and CD19, may be derived from CD5-positive B-cell precursors in bone marrow and not from mature B cells in lymph nodes.

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Hematological Observations on Bone Marrow Obtained by Sternal Puncture

Cited by 55 publications

References 10 publications

Congenital (Erythroid) Hypoplastic Anemia

Congenital (Erythroid) Hypoplastic Anemia

Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry

Expression of CD5 on Hematogones in a 7-Year-old Girl with Shwachman-Diamond Syndrome

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