Hematological Manifestation in Lung, Breast and Git Malignencies :A Discriptive Study

Abstract

Background: Malignancy is one of the principle causes of death both in developed and developing countries.Methods: 102 lung, GIT and Breast malignancies patients were selected. The various hematological abnormalities in lung, GIT and breast malignancies were evaluated by estimation of hematological parameter. Complete hematological investigation was performed using Abbott cell-3700dyn hematology analyzer and peripheral smear using Field's stain.Result: Hematological abnormalities were seen in Lung, GIT and Breast malignancies. The Anemia in 71(69.6%) cases of malignancies is most common hematological manifestation. The predominant peripheral smear finding was that of normocytic normochromic anemia (57.7%). The prevalence of leucocytosis and thrombocytosis were 33.3% and 36.2%. Conclusion:The present study showed a definite association of hematological manifestations viz anemia, leucocytosis and thrombocytosis with lung, GIT and breast malignancies.

Abnormalities in Hematological Profile in Solid Tumors/Non-Hematological Malignancies

“…21patients were microcytic hypochromic. We found normocytic hypochromic to be the most common, which is different from other studies who found normocytic normochromic the most common type of anemia [1,2].…”

“…In our study on 98 newly diagnosed solid tumor patients, we found anemia was present in 89 (90.82%) patients. This frequency was close to the reports by other studies by [1,2,6,7].…”

“…In our study, leukocytosis was detected in 19 out of 98 patients (19.38%) in various solid tumors at the time of diagnosis. Other studies have also observed 20%, 30% and 33.3% leucocyte count as in solid tumors [2,4,13]. We further found that among leukocytosis, neutrophilia was seen in 78.94% patients.…”

“…cases [1,2]. The lower frequency of thrombocytosis in our study could be because of the reason that higher platelet counts are associated with advanced tumor stage and since our patients included were diagnosed at early stage, hence the low frequency.…”

“…One of the most common nding present in cancer patients is anemia [2].The origin of anemia is multifactorial, the three main mechanisms include blood loss, increased destruction of red blood cells (RBCs) and decreased production of functional RBCs. Amongst the metastatic solid tumors, anemia is mainly seen in gynecologic malignancies (49%), colo-rectal cancers (39%), lung cancer (38%), breast cancer (30%) and uro-genital malignancies (29%) [3].…”