Hematological Findings among Jordanian Children with Celiac Disease at Presentation : A Retrospective Analytical Study

Rwalah, Mohammad; Hijazeen, Ruwaida; Kamal, Nazmi; Ghanma, Abdallah; Alzeben, Zeben; D'ajeh, Raha

doi:10.12816/0008059

Cited by 1 publication

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abnormal laboratory tests are not uncommon in patients with celiac disease at presentation, and hematological abnormalities are the most prevalent. A previous study from Royal Medical Services reported 30% of their cohort to have anemia [ 18 ]. In our cohort anemia was the most prominent abnormality, affecting almost half of the patients (45.7%).…”

Section: Discussionmentioning

confidence: 99%

Celiac Disease in South Jordan

Altamimi

2017

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

PurposeCeliac disease, an autoimmune enteropathy triggered by exposure to gluten, is not uncommon in South Jordan. However, its prevalence is underestimated due to lack of physician awareness of the diversity of disease presentation. The clinical spectrum includes classic gastrointestinal manifestations, as well as rickets, iron-deficiency anemia, short stature, elevated liver enzymes, and edema. Our goal was to evaluate celiac disease presentation in clinically diagnosed children.MethodsRetrospective study included all children diagnosed with celiac disease between September 2009 and September 2015. Hospital charts were reviewed. Demographic data, clinical characteristics, and follow-up were recorded.ResultsThirty-five children were diagnosed with celiac disease during the study period. Mean age±standard deviation was 6.7±3.8 years (range, 2.0–14 years). There were 17 (48.6%) female patients. The average duration between onset of symptoms and diagnosis was 16.3±18.7 months. Fifteen (42.9%) patients presented with classic malabsorption symptoms, whereas 7 (20.0%) patients presented with short stature. Positive tissue transglutaminase antibodies (tTg)-immunoglobulin A (IgA) was seen in 34 (97.1%) patients. The one patient with negative tTg-IgA had IgA deficiency. Although tTG-IgA values were not available for objective documentation of compliance, clinical data (resolution of presenting abnormalities and growth improvement) assured acceptable compliance in 22 (62.9%) patients.ConclusionCD in children may present with diverse picture. Although of the small number, the non-classical presentations are not uncommon in our rural community. Gluten-free diet is the main strategy for treatment and associated with usually correction of laboratory abnormalities and improvement of growth.

show abstract

Section: Discussionmentioning

confidence: 99%

Celiac Disease in South Jordan

Altamimi

2017

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

show abstract

Hematological Findings among Jordanian Children with Celiac Disease at Presentation : A Retrospective Analytical Study

Cited by 1 publication

References 42 publications

Celiac Disease in South Jordan

Celiac Disease in South Jordan

Contact Info

Product

Resources

About