Hematological features in malarial infection and their variations with parasite density: A retrospective analysis of 6-year data in an Indian city

Motchan, Prabu Anandhan; Subashchandrabose, Priya; Madhu, B; Suryanarayan, Anita

doi:10.4103/ijhas.ijhas_57_18

Cited by 5 publications

(5 citation statements)

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“…Anemia, thrombocytopenia, leukopenia and reduced RBCs count are frequent in malaria. 9 Latif et al found thrombocytopenia, leukopenia, and anemia to be more common in P. falciparum compared to P. vivax infection. 10 In the current study, the mean platelet count was found to be low in both groups, with a mean of 80000 in P. falciparum and 11171.1 in P. vivax infections.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile and Spectrum of Complications of Malaria in Hospitalized Children at a Tertiary Care Hospital

Waris¹,

Aurengzeb²,

Raza³

et al. 2021

JRMC

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Background: In children, clinical profile of malaria may vary from nearly asymptomatic disease to febrile illness leading to life threatening complications. The mortality among children is largely due to complications like cerebral malaria, severe anemia and pulmonary complications. The current study was conducted to study the clinical profile of malaria, its complications and factor associated with its complications. Methodology: This observational study was conducted at Children Hospital, PIMS from March 2018 to March 2021. All patients with positive immunochromatographic test and needing hospitalization due to unsettled fever or other troublesome symptom were included. Total 53 patients were included in the study. All patients underwent routine investigations which included ICTMP, complete blood picture, ultrasound abdomen, chest x rays, and routine urinary analysis. Severe malaria was characterized upon WHO guidelines. Patients were treated with chloroquine while those resistant to chloroquine were given artemisinin-based therapy. Data was analyzed by applying appropriate statistical tests via SPSS v 20. Results: Mean age of the patients was 5.80±3.5 years with male predominance (n=32, 60.4%). Majority of the patients had P.vivax (n=45, 84.9%) infection followed by P.falciparum (n=5, 9.4%), while 3 patients (5.7%) had positive immunochromatographic test for both P.vivax and P.falciparum. Severe malaria developed in 17 (32.1%) of the patients. Most common complication was severe anemia (n=10, 18.8%) followed by black water fever, ADEM disease, pneumonia and convulsions Patients with P.falciparum infection had higher risk (OR=8.00, P-value=0.07) of developing complication compared to P.vivax one. Conclusion: Rate of severe malaria was found to be 32.1% in children of current study which is quite high. Therefore, every child with malaria should be properly investigated for complications and treated accordingly.

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Section: Discussionmentioning

confidence: 99%

Clinical Profile and Spectrum of Complications of Malaria in Hospitalized Children at a Tertiary Care Hospital

Waris¹,

Aurengzeb²,

Raza³

et al. 2021

JRMC

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“…A retrospective study in India showed that thrombocytopenia was the most prominent feature among malaria-infected patients followed by anemia. Thrombocytopenia as a test for malaria diagnosis has the highest sensitivity of 82.43%, specificity of 89.55%, positive likelihood ratio of 7.89, negative likelihood ratio of 0.20, positive predictive value (PPV) of 89%, and negative predictive value (NPV) of 90% [ 41 ].…”

Section: Diagnostic Significance Of Platelet Indices For Malaria Infe...mentioning

confidence: 99%

Role of Platelet Indices as a Potential Marker for Malaria Severity

Bayleyegn

Asrie

Yalew

et al. 2021

Journal of Parasitology Research

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Purpose. Platelet parameter alteration such as platelet count and platelet indices are more common than in other blood cell lines due to diverse causative pathophysiological mechanisms in severe malaria infection. In malaria patients, no more studies evaluated platelet indices in relation to disease severity and prognosis. Therefore, this review assessed the current scientific knowledge on the potential role of platelet indices for the diagnostic marker of severe malaria infection. Results. Hence, after reviewing recent literatures, elevation of mean platelet volume and platelet distribution width in addition to decreased plateletcrit and platelet counts is the known potential risk factor associated with warning signs of severe malaria. Thus, thrombocytopenia < 150 × 10 9 / L , MPV ≥ 9.05 fL , and PDW ≥ 14.550 % as well as significantly higher P-LCR and decrease in PCT are shown significant sensitivity and specificity as they are used as diagnostic and prognostic values in severe malaria infection. Conclusion. Platelet indices are useful predictors of malaria severity. Immature platelet fraction (IPF%) is raised in the case of severe malaria, and it was significantly more useful than MPV. Advanced research will further investigate the platelet index abnormality associated with specific age and gender among specific malaria species.

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“…Motchan et al conducted a 6-year retrospective analysis of malaria cases and found malaria-positive cases presents with reduced levels of Hb, RBC count, HCT, TLC, platelet count and PCT whereas RDW, MPV and PDW were elevated significantly paralleled to comparative group. 21 Nishimura et al documented lower TLC and platelet count in malaria and dengue patients with higher MPV, PDW and MCHC. 22 Viswanathan et al has recorded the role of platelet indices in combination with CBC and clinical symptoms can aid in the diagnosis and treatment of tropical acute febrile illnesses.…”

Section: Discussionmentioning

confidence: 98%

“…The utility of haematological parameters in malaria, dengue and other acute febrile illnesses have been studied in the past. Motchan et al conducted a 6‐year retrospective analysis of malaria cases and found malaria‐positive cases presents with reduced levels of Hb, RBC count, HCT, TLC, platelet count and PCT whereas RDW, MPV and PDW were elevated significantly paralleled to comparative group 21 . Nishimura et al documented lower TLC and platelet count in malaria and dengue patients with higher MPV, PDW and MCHC 22 .…”

Section: Discussionmentioning

confidence: 99%

Discriminant value of automated leucocyte VCS parameters in the detection of tropical infections

Muthunatarajan

Basavaiah

Shenoy

et al. 2021

Clinical Laboratory Analysis

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Introduction: In India, infectious diseases are a leading treatable cause of morbidity and mortality. Mangalore being endemic to many vector-borne diseases, their incidence is known to show seasonal variations with sharp increase during monsoon.Leucocytes have substantial role in the immunological pathogenesis of infections. Methods:The present series was a hospital-based cross-sectional study performed in a tertiary care hospital for a period of three months from June-August wherein the cell population data of cases of malaria, dengue, leptospirosis, typhoid and rickettsial infections along with equal number of healthy controls were collected and analysed.Effectiveness of leucocyte-related volume (V), conductivity (C) and scatter (S) parameters by Coulter®DXH800 haematology analyser in predicting these infections was appraised.Results: A total of 324 cases comprising of malaria (50%), dengue (30.9%), leptospirosis (13.9%), typhoid (4.0%) and rickettsial infections (1.2%) were included. There was statistically significant differences (P < 0.05) in the mean values of complete blood count parameters-haemoglobin, total leucocyte count, red blood cell count, haematocrit, red cell distribution width, differential leucocyte count, platelet count and plateletcrit between cases and controls and also between specific infections. The mean volumes of neutrophil, monocyte and lymphocyte were considerably increased in malaria and dengue fever compared to leptospirosis, typhoid and rickettsial infections. VCS parameters were the least altered in typhoid fever, except for a strikingly high conductivity and scatter of eosinophils.Conclusions: Haematological analysis is a part of routine evaluation of any case of febrile illness. This study showed that there are specific alterations in VCS parameters in different types of infections such as malaria, dengue, leptospira, typhoid and rickettsia, the information and analysis of which comes without any additional cost.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Hematological features in malarial infection and their variations with parasite density: A retrospective analysis of 6-year data in an Indian city

Cited by 5 publications

References 1 publication

Clinical Profile and Spectrum of Complications of Malaria in Hospitalized Children at a Tertiary Care Hospital

Clinical Profile and Spectrum of Complications of Malaria in Hospitalized Children at a Tertiary Care Hospital

Role of Platelet Indices as a Potential Marker for Malaria Severity

Discriminant value of automated leucocyte VCS parameters in the detection of tropical infections

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