Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure

Feliciano, Amélia; Linhas, Rita; Marçôa, Raquel; Cysneiros, Ana; Martinho, C.; Reis, Roberto Palma dos; Penque, Deborah; Pinto, Paula; Bárbara, Cristina

doi:10.1016/j.rppnen.2016.12.001

Cited by 18 publications

(20 citation statements)

References 29 publications

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“…Significant decrease in MPV, hemoglobin and hematocrit levels in both OSAS groups after PAP treatment in OSAS is consistent with similar studies [29,30]. In our study, there was no statistically significant difference between the baseline and post-treatment platelet and PDW values, in which patients with moderate and severe OSAS were evaluated together.…”

Section: Discussionsupporting

confidence: 92%

Comparison of erythrocyte distribution width, mean platelet volume and platelet distribution width in patients with obstructive sleep apnea syndrome

Çelikhisar¹,

Ilkhan²

2019

Journal of Surgery and Medicine

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This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Reliable markers are needed to evaluate the response of chronic inflammation in obstructive sleep apnea syndrome (OSAS) to positive airway pressure (PAP) treatment. In this study, we aimed to investigate the long-term effects of PAP treatment on hemogram parameters and its relationship with inflammation and severity of disease in OSAS patients. Methods: Based on polysomnography (PSG) results, 61 (35.1%) participants and 113 OSAS patients (64.9%) were included in the control and study groups, respectively. Among these patients, 31.6% had moderate and 33.3% had severe OSAS. MPV, PDW, RDW, hemoglobin, hemotocrit, platelet values were evaluated and compared between the groups at six and twelve-month intervals in this prospective cohort study. Results: All participants (n=174) were males aged between 33-62 years. Hemoglobin, hematocrit and MPV values of the study group were significantly higher at the baseline (P=0.008, P=0.007, P=0.004, respectively) and had decreased significantly by the 6 th and 12 th months in both groups P=0.004, P=0.003, P=0.004, respectively). Conclusion: All participants were chosen from males to exclude hormonal effects on hemogram parameters, which also turned out to be a limitation of this study. Our study showed a correlation between MPV, RDW, PDW, hemoglobin and hematocrit values and OSAS severity. MPV, RDW, hemoglobin, hematocrit and platelet may be considered inexpensive biomarkers easily obtained from blood tests which make it useful in determining the severity of OSAS and prioritizing patients for PAP therapy. Öz Amaç: Obstrüktif uyku apne sendromunda (OUAS) intermitant hipoksiye bağlı gelişen kronik inflamasyonun PAP tedavisine yanıtını değerlendirmede kullanılacak güvenilir belirteçlere ihtiyaç vardır. Bu çalışmada, pozitif havayolu basıncı tedavisinin uzun dönem sonuçlarının hemogram parametreleri üzerine etkisini ve OUAS'lı hastalarda inflamasyon ve hastalığın ciddiyeti ile ilişkisini araştırmayı amaçladık. Yöntemler: Çalışma prospektif kohort tipi çalışma olarak planlandı. Polisomnografi (PSG) sonuçlarına göre OUAS saptanmayan 61 katılımcı (%35.1) kontrol grubu olarak alındı. OUAS saptanan 113 hasta (%64,9) çalışma grubu olarak alındı. Çalışma grubunun (%31,6)'sı orta OUAS, 58'i (%33,3) şiddetli OUAS idi. Hastaların MPV, PDW, RDW, hemoglobin, hemotokrit, trombosit değerleri değerlendirildi ve altı ve on iki ay arayla karşılaştırıldı. Bulgular: Yaşları 33 ile 62 arasında değişen, toplam 174 hasta çalışmaya alındı. Başlangıçta hemoglobin, hematokrit ve MPV değerleri çalışma grubunda kontrol grubuna göre anlamlı derecede yüksek (sırasıyla P=0,008, P=0,007, P=0,004), her iki grupta da 6 ve 12 aydaki düşüşler istatistiksel olarak anlamlıy...

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Section: Discussionsupporting

confidence: 92%

Comparison of erythrocyte distribution width, mean platelet volume and platelet distribution width in patients with obstructive sleep apnea syndrome

Çelikhisar¹,

Ilkhan²

2019

Journal of Surgery and Medicine

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“…Sokucu et al [14] did not find any significant difference in platelet count between OSA group and controls after 6 months of CPAP treatment. Feliciano et al [39] also reported a significant decrease in platelet count of 48 male OSA patients (18 mild, 5 moderate, 25 severe) after 6 months of CPAP therapy. Similar to Feliciano at al.…”

Section: Discussionmentioning

confidence: 89%

“…Sokucu et al [14] reported that 6 months of CPAP therapy significantly decreased MPV value but increased RDW. Feliciano et al [39] showed that RDW significantly decreased after PAP treatment. We also found a decrease in the mean RDW value of our patients after treatment.…”

Section: Discussionmentioning

confidence: 98%

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Tapan¹,

Görgülü²,

Tertemiz³

et al. 2017

J Sleep Disord Ther

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In this study, we aimed to evaluate the effect of CPAP treatment on hemograms of patients with severe OSA in the lack of comorbidities which might affect the real values of hematological parameters.This retrospective cohort study patients selected from those whose polysomnography reports were compatible with severe OSAS and who underwent PAP titration in our sleep medicine department. 49 patients were enrolled to the study. The baseline hemograms of the participants were collected from one of the patients' visits before they started to use CPAP devices. The control hemograms were evaluated from one of the control visits in the first six months of treatment. We examined the red cell distribution width (RDW), mean platelet volume (MPV), hemotocrit (Hct) and platelet (Plt) count from the hemograms.The mean age was 58.2 years ± 11.3 years, 38.8% were female and 61.2% were male. 69.4% were non-smokers and 30.6% were ex-smokers. The mean body mass index (BMI) was 31.6 ± 5.8 while the mean apnea hypopnea index (AHI) was 50.2 ± 29. The mean duration of CPAP therapy was 4.8 months ± 3.3 months. The mean RDW, MPV, Hct and Plt count values before CPAP treatment were in normal ranges of laboratory tests. All of the values reduced after CPAP therapy but only the decrease in MPV was statistically significant.The reduced values supported that CPAP treatment helped to control hypercoagulability and prevented from cardiovascular disorders in OSAS. Hemogram may be a cheap and easily found laboratory test for monitoring the response to CPAP therapy.

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“…Feliciano et al found that hemoglobin levels were 15.3±1.1 before treatment and 14.9±1 (p<0.0001) after treatment in a hematological parameter study on OSAS patients (8). Hemoglobin levels were elevated in OSAS and significantly decreased with treatment (8). Erythropoietin levels increase in hypoxic conditions, and there is a tendency for polycythemia to occur (9, 10).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

Eurasian J Pulmonol

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Eurasian J Pulmonol 2017 INTRODUCTIONObstructive sleep apnea syndrome (OSAS) is an episodic disease that is characterized by intermittent partial interruption of breathing during sleep, which results in low oxygen levels in organs and tissues (1). The characteristic symptoms of OSAS include snoring, apnea or hypopnea and excessive daytime sleepiness (2). OSAS occurs in approximately 3-7% of males and 2-5% of females in the general population and is a significant cause of mortality and morbidity (3). OSAS is diagnosed and classified according to the apnea-hypopnea index (AHI) in polysomnography (PSG). AHI> 5 indicates OSAS, with AHI of 5-15 indicating mild, 15-30 indicating moderate, and over 30 indicating severe OSAS (4).Changes in oxygen saturation and frequent awakening episodes in OSAS can also damage respiratory, cardiac, metabolic, and cognitive functions (5). High hypoxemia and elevated AHI cause dysfunction of the pancreatic beta cells (6). In previous studies, fasting blood sugar and HbA 1c elevation were Uncorrected AbstractObjective: Obstructive sleep apnea syndrome (OSAS) is an episodic disease that is characterized by intermittent partial interruption of breathing during sleep, which results in low oxygen levels in organs and tissues. The characteristic symptoms of OSAS include snoring, apnea or hypopnea and excessive daytime sleepiness. Our aim is to determine the early diagnosis of diabetes and to initiate treatments for OSAS patients according to the results of PSG in the sleep polyclinic based on fasting blood glucose and HbA 1c levels in patients with known OSAS without diabetes. Methods:Patients who applied to the sleep polyclinic of the Pamukkale University and were diagnosed with OSAS using PSG were included in the study.Results: A total of 44 patients with OSAS and a control group consisting of 47 people meeting these criteria were included. Compared with the control group, the patient groups showed significantly higher Hb values (p<0.05) and lower mean corpuscular volume (MCV) (p<0.05). Significant negative correlations were found between glucose levels and mean O2 saturation values in patients with severe OSAS (AHI>30) (r=-0.583, p=0.02). Conclusion:In conclusion, even though significant differences were not found in the glucose and HbA1c levels of patients with OSAS, glucose metabolism was deteriorated when saturation was decreased in severe OSAS. Therefore, glucose levels should be observed frequently, particularly in severe cases of OSAS or in patients with hypoxia, regardless of the stage. More attention should also be paid to the development of diabetes.

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Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure

Cited by 18 publications

References 29 publications

Comparison of erythrocyte distribution width, mean platelet volume and platelet distribution width in patients with obstructive sleep apnea syndrome

Comparison of erythrocyte distribution width, mean platelet volume and platelet distribution width in patients with obstructive sleep apnea syndrome

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

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