Hematological effects of glyphosate in mice revealed by traditional toxicology and transcriptome sequencing

He, Yuhong; Xiong, Fei; Qian, Yongkang; Xu, Kai; Pu, Yunqiu; Huang, Jiawei; Liu, Manman; Ye, Lihong; Zhang, Juan; Pu, Yuepu; Sun, Rongli

doi:10.1016/j.etap.2022.103866

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Another study reported that rice wine can potentially reduce stress-induced depression-like behaviors and FOS expression in rats [ 28 ]. In addition, FOS was associated with Gly-induced hematotoxicity via dysregulation of hematopoietic stem cell function [ 19 ] and Gly-induced anxiety and depression-like behavior in mice was accompanied by increased FOS expression in brain tissues [ 1 ]. However, it remains unclear whether FOS is a key molecule in Gly-induced MDD.…”

Section: Discussionmentioning

confidence: 99%

Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach

Li,

2024

Ann Gen Psychiatry

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Major depressive disorder (MDD) is predicted to become the second most common cause of disability in the near future. Exposure to glyphosate (Gly)-based herbicides has been linked to the onset of MDD. However, the underlying mechanisms remain unclear. The aim of this study was to investigate the potential molecular mechanisms of MDD induced by Gly using network toxicology approach. The MDD dataset GSE76826 from the Gene Expression Omnibus database was referenced to identify differentially expressed genes (DEGs) in peripheral blood leukocytes of MDD patients and controls. The potential intersection targets of Gly-induced MDD were screened by network toxicology. The intersection targets were used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and to construct protein–protein interaction networks. The binding potentials of hub targets with Gly were validated by molecular docking. In total, 1216 DEGs associated with Gly-induced MDD were identified. Subsequent network pharmacology further refined the search to 43 targets. GO and KEGG enrichment analyses revealed multiple signaling pathways involved in GLY-induced MDD. Six potential core targets (CD40, FOXO3, FOS, IL6, TP53, and VEGFA) were identified. Finally, molecular docking demonstrated that Gly exhibited strong binding affinity to the core targets. The results of this study identified potential molecular mechanisms underlying Gly induced MDD and provided new insights for prevention and treatment.

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Section: Discussionmentioning

confidence: 99%

Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach

Li,

2024

Ann Gen Psychiatry

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Effects of glyphosate exposure on the miRNA expression profile and construction of the miRNA-mRNA regulatory network in mouse bone marrow cells

Liu

Xiong

et al. 2022

Funct Integr Genomics

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Occupational Exposure to Pesticides Affects Pivotal Immunologic Anti-Tumor Responses in Breast Cancer Women from the Intermediate Risk of Recurrence and Death

Silva

Scandolara

Kern

et al. 2022

Cancers

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Breast cancer risk stratification is a strategy based using on clinical parameters to predict patients’ risk of recurrence or death, categorized as low, intermediate, or high risk. Both low and high risk are based on well-defined clinical parameters. However, the intermediate risk depends on more malleable parameters. It means an increased possibility for either suboptimal treatment, leading to disease recurrence, or systemic damage due to drug overload toxicity. Therefore, identifying new factors that help to characterize better the intermediate-risk stratification, such as environmental exposures, is necessary. For this purpose, we evaluated the impact of occupational exposure to pesticides on the systemic profile of cytokines (IL-12, IL-4, IL-17A, and TNF-α) and oxidative stress (hydroperoxides, total antioxidants, and nitric oxide metabolites), as well as TGF-β1, CTLA-4, CD8, and CD4 expression, investigated in tumor cells. Occupational exposure to pesticides decreased the levels of IL-12 and significantly increased the expression of TGF-β1 and CTLA-4 in the immune infiltrate. Nevertheless, we observed a decrease in CTLA-4 in tumor samples and CD8 in infiltrating cells of intermediate overweight or obese patients with at least one metastatic lymph node at the diagnosis. These findings indicate that occupational exposure to pesticides changes the molecular behavior of disease and should be considered for intermediate-risk stratification assessment in breast cancer patients.

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Hematological effects of glyphosate in mice revealed by traditional toxicology and transcriptome sequencing

Cited by 3 publications

References 45 publications

Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach

Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach

Effects of glyphosate exposure on the miRNA expression profile and construction of the miRNA-mRNA regulatory network in mouse bone marrow cells

Occupational Exposure to Pesticides Affects Pivotal Immunologic Anti-Tumor Responses in Breast Cancer Women from the Intermediate Risk of Recurrence and Death

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