Hematological effect of benzene exposure with emphasis of muconic acid as a biomarker

Ibrahim, K.; Amer, Nagat M.; El-dossuky, Elsaid A; Emara, Ahmed Mamdouh; El-Fattah, Abd; Shahy, Eman M.

doi:10.1177/0748233712458141

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…In agreement with our study, Ibrahim et al (2012) reported that many solvents in paint materials may be responsible for decrease in RBCs, WBCs, and platelets in exposed painters as compared with the non-exposed controls. They stated that organic solvents Table 9 Correlation between duration of exposure of workers (years) to paint hazards and different biochemical markers in paints may impair the immune system and could be considered as immune suppressors.…”

Section: Discussionsupporting

confidence: 82%

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Maksoud

Aal

Ghandour

et al. 2018

Egypt J Forensic Sci

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Background: Occupational exposures to hazardous chemicals in paints cause serious health hazards in painters. The present study was designed to evaluate the possibility of hematotoxic and genotoxic effects of paint chemicals among painters in Assiut Governorate, Egypt. In addition the role of oxidative stress and apoptosis in mechanism of such toxic effects were studied. Methods: A case control study was performed on 50 male painters and 50 non-exposed healthy subjects, who were included as a control group after informed consent. Venous blood samples were obtained and analyzed for determination of total and differential blood count as hematotoxic markers as well as serum malondialdehyde (MDA) as an oxidant stress markers and total antioxidant enzymes. In addition, human B-cell lymphoma-2 (Bcl-2), caspase-3 and 8-hydroxyguanosine (8-OHdG) were assayed as markers of apoptosis and genotoxicity. Results: There was a statistically significant difference between paint workers and controls as regard total and differential blood count, serum MDA and total anti-oxidant levels. Also, statistical significant differences in caspase-3, Bcl-2 levels and 8-OHdG were observed. Conclusions: Chronic occupational exposure to paints increased the risk of hematotoxicity and genotoxicity in painters. Oxidative stress and apoptosis play a major role in such mechanism. Periodic medical examination and application of protective devices is necessary.

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Section: Discussionsupporting

confidence: 82%

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Maksoud

Aal

Ghandour

et al. 2018

Egypt J Forensic Sci

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“…6 Occupational exposure, studies have reported higher platelet count (PLT) in pesticide workers, 7,8 firefighters, 9 cement factory workers, 10 taxi drivers 11 and metallic mercury workers, 12 as well as those exposed to noise 13 and diesel exhaust inhalation. 14 Low platelet counts were reported in gasoline filling workers, 15,16 and those exposed to gas flares 17 and benzene, 18 as well as beedi rollers. 19 Lead affects the blood coagulation actions through endothelial tissue injury, reduced nitric oxide, tissue plasminogen activator and an increased production of plasminogen activator inhibitor-1.…”

Section: Introductionmentioning

confidence: 99%

Effects of lead exposure on the status of platelet indices in workers involved in a lead-acid battery manufacturing plant

Barman¹,

Kalahasthi²,

Rajmohan³

2014

J Expo Sci Environ Epidemiol

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This study was carried out to determine the effect of Pb exposure on the status of platelet indices in workers exposed to Pb during lead-acid battery plant process. Platelet indices and blood lead levels (BLLs) were determined in 429 male workers. BLLs were determined by using an atomic absorption spectrophotometer. Platelet indices in the samples were quantified by using the Sysmex KX-21 hematology analyzer. The levels of platelet count (PLT), plateletcrit (PCT) and mean platelet mass (MPM) were significantly decreased and platelet distribution width (PDW), platelet large cell ratio (P-LCR) and mean platelet volume were increased with an increase in BLLs. The results of linear multiple regression analysis showed that the platelet count (β -0.143, P=0.005), PCT (β -0.115, P=0.023) and MPM (β -0.110, P=0.030) were negatively associated with BLLs and P-LCR (β 0.122, P=0.016) was positively associated with BLLs. The variable of body mass index showed a positive association with PCT (β 0.105, P=0.032) and MPM (β 0.101, P=0.039). The results of the study may indicate that lead exposure may impair coagulation function through endothelial tissue injury and reduction of nitric oxide.

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“…Traffic-related volatile organic compounds (VOCs) pollution has frequently been demonstrated to be a more serious problem in the developing countries than in the United States and Europe, as indicated by the VOC data obtained in Thailand, India, Pakistan and Egypt (Arayasiri et al, 2010;Rekhadevi et al, 2010;Kamal et al, 2012;Ibrahim et al, 2012). In Beirut, capital of Lebanon, air pollutant concentrations currently exceed air quality standards and guidelines (Waked and Afif, 2012).…”

Section: Introductionmentioning

confidence: 99%

Traffic-related air pollution. A pilot exposure assessment in Beirut, Lebanon

et al. 2014

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Traffic-related volatile organic compounds (VOCs) pollution has frequently been demonstrated to be a serious problem in the developing countries. Benzene and 1,3-butadiene (BD) have been classified as a human carcinogen based on evidence for an increased genotoxic and epigenotoxic effects in both occupational exposure assessment and in vivo/in vitro studies. We have undertaken a biomonitoring of 25 traffic policemen and 23 office policemen in Beirut, through personal air monitoring, assessed by diffusive samplers, as well as through the use of biomarkers of exposure to benzene and BD. Personal benzene, toluene, ethylbenzene, and xylene (BTEX) exposure were quantified by GC-MS/MS, urinary trans, trans-muconic acid (t,t-MA) by HPLC/UV, S-phenyl mercapturic acid (S-PMA), monohydroxy-butenyl mercapturic acid (MHBMA) and dihydroxybutyl mercapturic acid (DHBMA) by ultra-performance liquid chromatography-electrospray tandem mass spectrometry (UPLC/ESI(-)-MS/MS) in MRM (Multiple Reaction Monitoring) mode. We found that individual exposure to benzene in the traffic policemen was higher than that measured in traffic policemen in Prague, in Bologna, in Ioannina and in Bangkok. t,t-MA levels could distinguish between office and traffic policemen. However, median MHBMA levels in traffic policemen were slightly elevated, though not significantly higher than in office policemen. Alternatively, DHBMA concentrations could significantly distinguish between office and traffic policemen and showed a better correlation with personal total BTEX exposure. DHMBA, measured in the post-shift urine samples, correlated with both pre-shift MHMBA and pre-shift DHMBA. Moreover, there was not a marked effect of smoking habits on DHBMA. Taken together, these findings suggested that DHBMA is more suitable than MHBMA as biomarker of exposure to BD in humans. Traffic policemen, who are exposed to benzene and BD at the roadside in central Beirut, are potentially at a higher risk for development of diseases such as cancer than office policemen.

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Hematological effect of benzene exposure with emphasis of muconic acid as a biomarker

Cited by 12 publications

References 29 publications

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Effects of lead exposure on the status of platelet indices in workers involved in a lead-acid battery manufacturing plant

Traffic-related air pollution. A pilot exposure assessment in Beirut, Lebanon

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