Hematological disorders: a commonly unrecognized cause of acute stroke

Arboix, Adrià; Jiménez, Carme; Massons, Joan; Parra, Olga; Besses, Carles

doi:10.1080/17474086.2016.1208555

Cited by 75 publications

(41 citation statements)

References 56 publications

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“…7 Cerebral ischemia is the most common ischemic manifestation in ET cases. 8 Platelets play an important role in the process of thrombus formation (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Successive development of ischemic stroke and hemorrhagic stroke in a patient with essential thrombocythemia: a case report

2021

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Patients with essential thrombocythemia (ET) can experience hemorrhagic or ischemic vascular events. The prevention of these complications is challenging, and the overall risk of vascular events caused by ET is often overlooked. A 34-year-old man was admitted for a 10-day history of weakness and numbness in his right limbs. He had been diagnosed with ET in 2008 but had stopped receiving treatment half a year before admission. Physical examination showed a superficial sense of disturbance in the right limbs and decreased muscle strength in the right upper and lower limbs (4/5). His platelet count (459 × 109/L) was elevated. Magnetic resonance imaging showed acute watershed infarction, and he was treated successfully. However, he was readmitted for headache and left limb weakness 14 months later. A head computed tomography scan revealed spontaneous subdural hemorrhage. He underwent subdural hematoma removal and decompressive craniectomy. Surgery and pathological investigation revealed no venous sinus thrombosis or vascular malformation. His condition improved, and he exhibited a stable condition 1 year after discharge. Successive development of ischemic stroke and spontaneous subdural hemorrhage is rare in a patient with ET. This case suggests that ET is not only a risk factor for stroke but can also cause highly heterogeneous strokes.

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“…7 Cerebral ischemia is the most common ischemic manifestation in ET cases. 8 Platelets play an important role in the process of thrombus formation (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Successive development of ischemic stroke and hemorrhagic stroke in a patient with essential thrombocythemia: a case report

2021

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“…Bizim çalışmamızda da küçük damar hastalığının en sık olmasının sebebi sigara içme oranının yüksek olması olabilir. Arboix A. ve ark.sigara içmenin ( > 20 adet/gün) genç yaşta görülen laküner enfarktlar için bağımsız bir risk faktörü olduğunu belirtmişlerdir (31).…”

Section: Discussionunclassified

Üçüncü Basamak Sağlık Merkezinde Genç İskemik İnme Hastalarında Etiyolojik inceleme

İnan

Özer

Barut

2021

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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The aim of this study is to investigate the association of age and gender with stroke etiology and risk factors in young patients with ischemic stroke and to determine probable risk factors causing stroke recurrence in patients with recurrent stroke. Material and Methods:Records of 150 patients under the age of 55 who were admitted with the diagnosis of acute ischemic stroke in our hospital were reviewed retrospectively. Patients' demograhic data, vascular risk factors, biochemical tests and imaging findings for stroke etiology were recorded. Etiologic stroke subtypes were determined using TOAST classification. Risk factors and stroke subtypes of the patients with first-time stroke and recurrent stroke were evaluatedaccording to gender and age.Results: 111 (74%) of the patients were male, 39 (26%) were female. 83 patients (55.3%) were 45 years of age and younger. The most common risk factors were hypertension ( 46%), smoking (45.3%) and dyslipidemia (32.7%).The rate of smoking among the males were significantly high ( p<0.0001). Hypertension and diabetes mellitus were more common in patients older than 45 years of age (p=0.009, p=0.022). A statistically significant relationship with age and hypertension in male patients was determined (p=.003). Small vessel disease was the most common stroke subtype in both age groups. 19 patients (12.6%) had recurrent stroke. No statistically significant difference was detected between the patients' groups of first-time and recurrent stroke regarding to risk factors and stroke subtype. Conclusion:Hypertension, smoking and hyperlipidemia are the most common risk factors in young population and stroke risk is higher in diabetic and hypertensive males aged 45 and older. To detect and treat the modifiable risk factors in young patients is important to prevent stroke recurrence.

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“…Hereditary hematologic disorders (HHD) refer to the medical conditions that affect the blood (or its components) to work properly. HHD may result from disorders in the bone marrow and the fatty area inside the bones that produces new red blood cells, white blood cells, and platelets (1). Thalassemia is one of the genetic HHD and is one of the most widespread genetic diseases in the world with a particularly high frequency in tropical and sub-tropical areas such as Mediterranean countries, the Indian subcontinent, the Middle East, North Africa and Southeast Asia (2).…”

Section: Introductionmentioning

confidence: 99%

Hereditary Hematologic Disorders in Najaf Province-Iraq

Al‐Hakeim¹,

Abdulla²,

Almulla³

et al. 2020

Preprint

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Background: Hereditary hematologic disorders (HHDs) originate from genetic factors that cause disruptions of blood homeostasis. The Thalassemia Unit, Najaf province, Iraq, keeps all medical records of all patients with HHD from the Najaf province. Objectives: We aimed to conduct an epidemiological study to obtain a comprehensive epidemiological picture with regard to sex distribution, and effects of blood groups and consanguinity. Patients and Methods: All registered HHD patients (until May 2019) in the Thalassemia Unit (1122 patients, aged 0.5-65 years old) were included in the study. Results: The prevalence of HHD in Najaf city is 75.6 per 100,000 population. The number of patients registered as new patients is increasing over the years. There are significantly more male than female HHD patients (Male=54.37%, Female=45.63%, p=0.023). The top 3 prevalent HHD are Major thalassemia (33.15%), intermediate thalassemia (31.91%), and Thalassemia+Sickle (12.65%). The highest percentage of patients were in the center of Najaf (56.42%) followed by Kufa, Mishkhab, Haidariah, Manathera, and Abbasiya. The distribution of blood groups and Rh factors of HHD patients in the Najaf population was not significantly different from that in the normal population. The consanguinity rate observed in our patients' parents (78.24%) was significantly higher (p<0.0001) as compared with the consanguinity rate in the population (45.8%). Conclusions: During the last few years, there was an increase in HHD cases in Najaf city and, therefore, there is an urgent need to increase awareness about the effects of consanguinity marriages on HHD in order to limit the incidence of HHD.

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Hematological disorders: a commonly unrecognized cause of acute stroke

Cited by 75 publications

References 56 publications

Successive development of ischemic stroke and hemorrhagic stroke in a patient with essential thrombocythemia: a case report

Successive development of ischemic stroke and hemorrhagic stroke in a patient with essential thrombocythemia: a case report

Üçüncü Basamak Sağlık Merkezinde Genç İskemik İnme Hastalarında Etiyolojik inceleme

Hereditary Hematologic Disorders in Najaf Province-Iraq

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