Hematological and biochemical predictors of bone marrow metastases in non-hematological malignancies: a clinico-pathological analysis

Agrawal, Shailesh; Bhandari, Rajiv; Gowda, Vinay N; Gupta, Amit; Singh, Neha; Chowdhury, Nilotpal; Rao, Shalinee; Kishore, Sanjeev; Gupta, Arvind; Chandra, Harish

doi:10.1101/2020.12.16.20248306

Cited by 2 publications

(2 citation statements)

References 22 publications

(38 reference statements)

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“…The first-line treatment regimens and side effects observed are summarised in Table 3. Progression was observed in four (40.0%) of 10 patients who received treatment with the first series of treatment, three (30.0%) patients were stable and three (30.0%) (7). In the study of Kilickap et al in which 3842 bone marrow biopsy materials were evaluated, the rate of total solid organ metastasis to the bone marrow was found to be 1.9% (8).…”

Section: Resultsmentioning

confidence: 98%

Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

BAYİR GARBİOGLU,

YILDIZ,

IŞIKSOY

et al. 2023

Batı Karadeniz Tıp Dergisi

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Aim: Although solid tumors are known to metastasize to the bone marrow, it is rare to be diagnosed with bone marrow involvement. In our study, we aimed to contribute to the literature by evaluating the treatment results and follow-up processes of different solid tumors metastatic to bone marrow in denovo. Material and Methods: We retrospectively analyzed 28 patients who underwent bone marrow biopsy with a prediagnosis of hematologic malignancy and were diagnosed with carcinoma metastasis. Clinicopathologic features, antitumor treatments, treatment-related hematologic toxicities and factors affecting survival were evaluated. Results: Of the 28 patients included in the study, 14 (50.0%) were female and 14 (50.0%) were male. The median age of the patients was 62 years (28-82). Eight patients (28.6%) were diagnosed with breast (28.6%), six with gastric (21.4%), four with lung (14.3%), two each with colon and prostate ca (7.1%), and the primary tumor site could not be determined in six patients (21.4%). Progression was observed in four (40.0%) of the 10 patients with the first series of treatment, three (30.0%) patients had stable response and three (30.0%) patients had partial response. The median progression-free survival time was 130 days (3-494 days) in patients who received first line treatment. The median overall survival time was 26 days (0-1183 days). Thrombocytopenia (p

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Section: Resultsmentioning

confidence: 98%

Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

BAYİR GARBİOGLU,

YILDIZ,

IŞIKSOY

et al. 2023

Batı Karadeniz Tıp Dergisi

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“…Majority of these disorders present with vague clinical symptoms and poses difficulty for clinicians in the diagnosis based on complete blood picture and peripheral film only; necessitating the use of bone marrow aspiration and examination for diagnosis. 7 Rationale of the study is to ascertain the etiological spectrum of disorders on bone marrow examination which will guide the clinicians about the frequency of hematological and non-hematological disorders and their management in a clinical setup.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Hematological and Non-Hematological Diseases on Bone Marrow Examination-A Study on 220 Cases at a Tertiary Care Centre

Rauf¹,

Zafar²,

Asif³

2021

JRMC

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Background: Bone marrow examination is an invaluable tool in the diagnosis of hematological and non-hematological diseases. Referral is made based on the clinical after analyzing CBC and peripheral film.Objective: This study aims at evaluating the spectrum of diseases diagnosed on bone marrow biopsy at a tertiary care hospital of Rawalpindi, Pakistan.Materials and Methods: This descriptive, cross-sectional study was carried out at the pathology department of Holy family hospital for a duration of 1 year after ethical approval from IRF. All 220 cases requiring bone marrow examination were included in the study by consecutive sampling technique. Variables like age, gender, presenting complaints, examination findings, CBC, peripheral blood film, indications and diagnosis of bone marrow examination were noted. Data was analyzed using SPSS v22.Results: Mean age was 29.15±20.9 years. 117(53.2%) specimens were of males and 103(46.8%) were of females. Spectrum of hematological and non-hematological diseases found on bone marrow examination ranged from acute leukemia in 37(16.8%), megaloblastic anemia in 29(13.1%).The relationship between indications of referral and diagnosis of bone marrow examination was found to be statistically significant showing that suspected diagnosis made by the clinician was same as the final diagnosis in many cases. Pancytopenia was found major indication in most diseases (32.7%).Conclusion: Bone marrow examination is a useful tool in ascertaining diagnosis of various hematological and non-hematological disorders. Pancytopenia was found to be major indication whereas, acute leukemia and megaloblastic anemia were most common malignant and benign hematological disorders on bone marrow examination, respectively.

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Hematological and biochemical predictors of bone marrow metastases in non-hematological malignancies: a clinico-pathological analysis

Cited by 2 publications

References 22 publications

Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

Spectrum of Hematological and Non-Hematological Diseases on Bone Marrow Examination-A Study on 220 Cases at a Tertiary Care Centre

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