Hematological and Biochemical Parameters in Symptomatic and Asymptomatic Leishmania-Seropositive Dogs

Ulchar, Igor; Celeska, Irena; Stefanovska, Jovana; Jakimovska, Anastasija

doi:10.14432/j.macvetrev.2015.06.04

Cited by 3 publications

(2 citation statements)

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“…Low WBC count, but still within the reference range and no significant changes, were also observed in the SD. These results are in agreement with previous studies (Freitas et al, 2012;Ulchar, at al., 2015).The GRA were significantly decreased in the SD. Significantly higher GRA, especially neutrophils and eosinophils, were observed in different segments of intestinal tissue, lymph nodes , skin (Reis, et al, 2009), liver (Giunchetti, at al., 2008) and spleen (Barrouin-Melo, at al., 2006) in naturally or experimentally infected dogs with L. infantum.…”

Section: Resultssupporting

confidence: 94%

“…Reduced RBC count associated to reduce level of HGB due to impaired erythropoiesis, could be the main reason for low HCT and the lowest level of MCH (Reis, at al., 2009). Some authors have suggested that despite the hemodilution due to decreased erythropoiesis and/or increased hemolysis, polydipsia could also contribute to the low HCT (Ulchar, at al., 2015). Low WBC count, but still within the reference range and no significant changes, were also observed in the SD.…”

Section: Resultsmentioning

confidence: 99%

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Hematological changes in different clinical forms as a complementary diagnostic tool in canine Leishmaniasis

2020

HORIZONS

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The aim of this study was to evaluate the alterations in hematology parameters in relations to the different clinical forms in seropositive dogs to Leishmania infantum (L. infantum). Thirty seropositive dogs for Canine leishmaniasis (CanL) confirmed with an indirect fluorescent antibody test (IFAT), according to the clinical signs were allocated to three equal groups: asymptomatic (AD), oligosymptomatic (OD) and symptomatic dogs (SD). Blood samples were collected for hematology parameters analysis in all groups. A significant anemic profile was observed in the SD that correlates to the presence of specific symptoms in SD. Reduced granulocytes count and percentage in the SD and increased number of lymphocytes in the OD indicates on the complexity of immune response in the different clinical forms of CanL. The hematological changes can be considered a useful complementary tool for further evaluation of disease progression and prognosis in different clinical forms of CanL.

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Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Hematological changes in different clinical forms as a complementary diagnostic tool in canine Leishmaniasis

2020

HORIZONS

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IgG avidity index and complete blood count as biomarkers of clinical disease in naturally infected dogs with Leishmania infantum

Lopes

Belo

Pereira

et al. 2018

Veterinary Parasitology

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Global Distribution of Canine Visceral Leishmaniasis and the Role of the Dog in the Epidemiology of the Disease

Vilas-Boas,

Nakasone,

Gonçalves

et al. 2024

Pathogens

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Visceral leishmaniasis is a disease caused by protozoa of the species Leishmania (Leishmania) infantum (syn = Leishmania chagasi) and Leishmania (Leishmania) donovani, which are transmitted by hematophagous insects of the genera Lutzomyia and Phlebotomus. The domestic dog (Canis familiaris) is considered the main urban reservoir of the parasite due to the high parasite load on its skin, serving as a source of infection for sandfly vectors and, consequently, perpetuating the disease in the urban environment. Some factors are considered important in the perpetuation and spread of canine visceral leishmaniasis (CVL) in urban areas, such as stray dogs, with their errant behavior, and houses that have backyards with trees, shade, and organic materials, creating an attractive environment for sandfly vectors. CVL is found in approximately 50 countries, with the number of infected dogs reaching millions. However, due to the difficulty of controlling and diagnosing the disease, the number of infected animals could be even greater. In the four continents endemic for CVL, there are reports of disease expansion in endemic countries such as Brazil, Italy, Morocco, and Tunisia, as well as in areas where CVL is not endemic, for example, Uruguay. Socio-environmental factors, such as migration, drought, deforestation, and global warming, have been pointed out as reasons for the expansion into areas where it had been absent. Thus, the objective of this review is to address (i) the distribution of CVL in endemic areas, (ii) the role of the dog in the visceral leishmaniasis epidemiology and the factors that influence dog infection and the spread of the disease, and (iii) the challenges faced in the control of CVL.

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Hematological and Biochemical Parameters in Symptomatic and Asymptomatic Leishmania-Seropositive Dogs

Cited by 3 publications

References 36 publications

Hematological changes in different clinical forms as a complementary diagnostic tool in canine Leishmaniasis

Hematological changes in different clinical forms as a complementary diagnostic tool in canine Leishmaniasis

IgG avidity index and complete blood count as biomarkers of clinical disease in naturally infected dogs with Leishmania infantum

Global Distribution of Canine Visceral Leishmaniasis and the Role of the Dog in the Epidemiology of the Disease

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