Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco

Kantri, Aziza; Ziati, Jihane; Khalis, Mohamed; Haoudar, Amal; Aidaoui, Karim El; Daoudi, Youssef; Chikhaoui, Inas; Yamani, Khalid El; Mouhaoui, Mohammed; Bakkouri, Jalila El; Dini, N.; Mahi, Mohammed El; Naitlho, Abdelhamid; Bahlaoui, A.; Bennana, A; Noussair, Mustapha; Belyamani, Lahcen; Kettani, Chafik El

doi:10.1371/journal.pone.0246295

Cited by 28 publications

(33 citation statements)

References 30 publications

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“…To see the association between chronic illness and biochemical abnormalities, we conducted chi-square test which revealed that all the biochemical abnormalities were significantly associated with cardiac and endocrine diseases (p<0.05). Several studies and review conducted at China, Italy, Iran, Morocco, India, Iraq, UAE, USA revealed that various biochemical abnormalities are more prevalent among the COVID-19 patients with pre-existing comorbidities like hypertension, ischemic heart disease, diabetes which is similar to our study as well 23,[25][26][27][28][29][30][31] .…”

Section: Resultssupporting

confidence: 88%

Assessment of Biochemical Changes Among Covid-19 Cases in a Tertiary Hospital of Bangladesh During Early Pandemic

Mithun

Abdullah²,

Irfan

2022

JOPSOM

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Background: Corona virus disease 2019 (COVID-19) involves various organs of the body causing several biochemical changes which plays an essential role in estimating the patients’ condition and prognosis, directing treatment, and even evaluating the curative effects. The present study aimed to assess the biochemical changes among the COVID-19 patients during early pandemic. Methods: This cross sectional study was conducted at Combined Military Hospital (CMH) Dhaka among purposively selected 237 confirm COVID-19 cases. Data were collected through face to face interview and review of medical records using a pre-tested semi-structured questionnaire. The study was conducted in the Combined Military Hospital Dhaka from 15 April 2020 to 31 May 2020 Results: Highest number of the respondents were in the age group of 31-40 years (37.1%) with male predominance (83.1%). About 95.6% were Muslim and 58.6% were educated up to secondary level. About 87.8% had contact with a confirmed case and having 47.7%, 37.2%, 15.1% cardiovascular, endocrine and respiratory comorbidities respectively. Fever (34.6%) was the most common presenting symptoms followed by cough (22.9%), sore throat (10.6%). Neutrophilia observed in 26.16%, lymphopenia in 20.7%, thrombocytopenia in 14.3% cases, 30.0% with positive D-dimer test, 22.4% either sepsis or systemic infection in procalcitonin estimation, 28.3% with increased ferritin, 28.7% with positive C reactive protein, 21.1% with increased LDH. Chi-square analysis revealed a statistically significant association between cardiovascular and endocrine diseases with several biochemical changes (p<0.05). Conclusion: Early identification of various biochemical changes would help the physician for appropriate assessment and management. JOPSOM 2021; 40(1): 34-42

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Section: Resultssupporting

confidence: 88%

Assessment of Biochemical Changes Among Covid-19 Cases in a Tertiary Hospital of Bangladesh During Early Pandemic

Mithun

Abdullah²,

Irfan

2022

JOPSOM

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“…Studies of CRP levels in association with COVID-19 in Africa appear to be rare, but the metabolic marker may not be rare. Some reports indicated that CRP levels were associated with adverse outcomes in patients [89][90][91]. In general, CRP levels are high in many African countries or in African Americans, especially in association with diabetes, hypertension, or infectious diseases [92].…”

Section: C-reactive Protein (Crp)mentioning

confidence: 99%

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Pandemic: Are Africa’s Prevalence and Mortality Rates Relatively Low?

Mariam

2022

Advances in Virology

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of coronavirus disease 19 (COVID-19), has been rapidly spreading since December 2019, and within a few months, it turned out to be a global pandemic. The disease affects primarily the lungs, but its pathogenesis spreads to other organs as well. However, its mortality rates vary, and in the majority of infected people, there are no serious consequences. Many factors including advanced age, preexisting health conditions, and genetic predispositions are believed to exacerbate outcomes of COVID-19. The virus contains several structural proteins including the spike (S) protein with subunits for binding, fusion, and internalization into host cells following interaction with host cell receptors and proteases (ACE2 and TMPRSS2, respectively) to cause the subsequent pathology. Although the pandemic has spread into all countries, most of Africa is thought of as having relatively less prevalence and mortality. Several hypotheses have been forwarded as reasons for this and include warmer weather conditions, vaccination with BCG (i.e., trained immunity), and previous malaria infection. From genetics or metabolic points of view, it has been proposed that most African populations could be protected to some degree because they lack some genetic susceptibility risk factors or have low-level expression of allelic variants, such as ACE2 and TMPRSS2 that are thought to be involved in increased infection risk or disease severity. The frequency of occurrence of α-1 antitrypsin (an inhibitor of a tissue-degrading protease, thereby protecting target host tissues including the lung) deficiency is also reported to be low in most African populations. More recently, infections in Africa appear to be on the rise. In general, there are few studies on the epidemiology and pathogenesis of the disease in African contexts, and the overall costs and human life losses due to the pandemic in Africa will be determined by all factors and conditions interacting in complex ways.

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“…These results are in concordance with the findings of other researchers. [ 13 14 15 16 17 18 19 20 21 22 23 24 25 ] Waris et al . [ 26 ] also demonstrated similar results except that they did not find a significant association between disease severity and lymphocytopenia ( P value = 0.28).…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, serum CRP, ferritin and LDH were significantly high in patients with severe disease. Our findings were in concordance with the results of Shang et al .,[ 13 ] Ding et al .,[ 14 ] Keski et al .,[ 15 ] Kantri et al .,[ 17 ] Bhandari et al .,[ 19 ] Asan et al .,[ 20 ] Nizami et al .,[ 22 ] Asghar et al . [ 23 ] and Rahman et al .…”

Section: Discussionmentioning

confidence: 99%

Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

Sana¹,

Malviya²

2022

Journal of Family Medicine and Primary Care

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Background and Objectives: India has emerged as the second worst hit nation by the Coronavirus pandemic in terms of total number of cases. Our data on hematological and inflammatory markers associated with COVID-19 is very limited. This study was conducted to assess the utility of various biomarkers in identifying severe disease. Materials and Methods: All confirmed cases of COVID-19 admitted in our tertiary care centre from 1 st March 2021 to 31 st March 2021 were enrolled in the study. They were categorized into severe and non-severe disease categories based on pre-decided criteria. Their complete blood count parameters, D-dimer levels, serum C-reactive protein (CRP), ferritin and Lactate dehydrogenase (LDH) values were retrieved. Statistical Analysis: All parameters were expressed as Mean ± Standard deviation for the two groups of patients. Student's t -test was used to test significance of the above markers between severe and non- severe disease. ( P value < 0.05 was taken as statistically significant). Results: A total of 150 COVID RT-PCR positive patients were evaluated. The patients with higher Absolute Neutrophil Count (ANC), Neutrophil to lymphocyte Ratio (NLR), Platelet to lymphocyte ratio (PLR), D-dimer levels and raised serum CRP, LDH, ferritin along with lymphocytopenia were associated with severe disease ( P < 0.05). Hemoglobin, total leucocyte count and platelet count showed no correlation with disease severity. Conclusion: These biomarkers associated with disease severity especially NLR, PLR, D-dimer and serum CRP levels could be used to triage patients at the time of admission thereby identifying those requiring intensive care and enabling optimal resource utilization.

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Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco

Cited by 28 publications

References 30 publications

Assessment of Biochemical Changes Among Covid-19 Cases in a Tertiary Hospital of Bangladesh During Early Pandemic

Assessment of Biochemical Changes Among Covid-19 Cases in a Tertiary Hospital of Bangladesh During Early Pandemic

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Pandemic: Are Africa’s Prevalence and Mortality Rates Relatively Low?

Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

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