Hematological abnormalities of 1.DEG. Sjogren's syndrome.

Aoki, Akiko; Ohno, Shigeru; Ueda, Athuhisa; Ideguchi, Haruko; Ohkubo, Tadanobu; Hagiwara, Eri; Shirai, Akira; Oketani, Mikako; Nagaoka, Shohei; Senuma, Akiko; Ohota, Shoichi; Matsunaga, Keiichiro; Ishigatsubo, Yoshiaki

doi:10.2177/jsci.23.124

Cited by 23 publications

(15 citation statements)

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“…The present case is consistent with all of these characteristics, which suggested the causal relationship between HCV infection and Sjögren's syndrome. syndrome (7,14). The prevalence of thrombocytopenia (<10×10 4 /mm 3 ) in Sjögren's syndrome is reported to be 3.6% to 7.1%, which is similar to that in CHC (2,7,14).…”

Section: Discussionsupporting

confidence: 55%

“…syndrome (7,14). The prevalence of thrombocytopenia (<10×10 4 /mm 3 ) in Sjögren's syndrome is reported to be 3.6% to 7.1%, which is similar to that in CHC (2,7,14). The degree of thrombocytopenia in Sjögren's syndrome is usually mild without need for treatment.…”

Section: Discussionmentioning

confidence: 58%

“…Even if treatment is needed, the response to PSL is generally favorable. Clinically, patients with Sjögren's syndrome and thrombocytopenia are significantly younger and have a higher tendency to have accompanying skin eruptions and anti-SS-B antibody than those without (7). On the other hand, the majority of patients with immune thrombocytopenic purpura related to HCV need treatment such as PSL and splenectomy, with the response to PSL much poorer than those unrelated to HCV (15).…”

Section: Discussionmentioning

confidence: 99%

“…In actuality, anemia, thrombocytopenia, and leucopenia are common in patients with Sjögren's syndrome, but they are usually mild and involvement of the cardiac muscle is quite rare (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Sjoegren's Syndrome Associated with Chronic Hepatitis C, Severe Thrombocytopenia, Hypertrophic Cardiomyopathy, and Diabetes Mellitus

et al. 2005

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A 74-year-old woman with Sjögren's syndrome and chronic hepatitis C (CHC) was admitted to our hospital in October 2003 for treatment of diabetes mellitus. She had the past history of recurrent thrombocytopenia, which was proven to be due to peripheral destruction. Although she had been diagnosed with hypertrophic cardiomyopathy (HCM) for 2 years, she had never felt palpitation. She suddenly died probably of fatal arrhythmia related to HCM during the last hospitalization.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sjoegren's Syndrome Associated with Chronic Hepatitis C, Severe Thrombocytopenia, Hypertrophic Cardiomyopathy, and Diabetes Mellitus

et al. 2005

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“…However, these hematologic features are mostly presented with isolated or combined cytopenia and recognized as mild laboratory abnormalities without clinical significance [9]. Several reports have demonstrated the clinical characteristics of thrombocytopenia observed in patients with SS [10,11]. The essentially asymptomatic course and fluctuating nature of the neutropenia and thrombocytopenia over many years appear to be characteristic of the autoimmune cytopenia in pSS [12].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment with intravenous immunoglobulin of severe thrombocytopenia complicated in primary Sjögren’s syndrome

Choung

Yoo

2010

Rheumatol Int

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Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular, hematological complications of SS. We report here a rare case of patient with primary SS who developed pancytopenia with severe thrombocytopenia as an initial manifestation and successfully treated with IV immunoglobulin (IVIG). The present case suggests that pancytopenia with severe thrombocytopenia can be a difficult-to-treat abnormality, and initial manifestation of primary SS and IVIG might be an effective treatment for severe thrombocytopenia refractory to high-dose steroid in primary SS.

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