Hematological abnormalities in HIV-infected patients

Santis, Gil Cunha De; Brunetta, Denise Menezes; Vilar, Fernando Crivelenti; Brandão, Renata Amorim; Muniz, Renata Zomer de Albernaz; Lima, Geovana Momo Nogueira de; Amorelli-Chacel, Manuela Emiliana; Covas, Dimas Tadeu; Machado, Alcyone Artioli

doi:10.1016/j.ijid.2011.08.001

Cited by 83 publications

(87 citation statements)

References 26 publications

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“…Previous studies9, 10, 11, 12, 13 had reported inconsistent results on how leukocyte and lymphocyte subsets vary in pregnancy of both HIV‐uninfected and HIV‐infected women in Africa. We observed that pregnancy alone, in the absence of HIV infection, was associated with a reduction in lymphocytes and T‐cell numbers across all subsets and with a neutrophilia consistent with what had been observed in some studies14, 15, 16, 17, 18 but not in others 19, 20, 21. This lack of consistence in changes in total lymphocytes and subsets in pregnancy found in the different studies could be because these cell subsets have previously been shown to be affected by other factors apart from pregnancy such as location and ethnic group 22…”

Section: Discussionsupporting

confidence: 88%

Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women

Mandala

Gondwe

Molyneux

et al. 2017

American J Rep Immunol

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ProblemWe investigated leukocyte and lymphocyte subsets in HIV‐infected or HIV‐uninfected, pregnant or non‐pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity.Method of studyWe recruited 54 pregnant and 48 non‐pregnant HIV‐uninfected women and 24 pregnant and 20 non‐pregnant HIV‐infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups.ResultsParturient HIV‐infected and HIV‐uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non‐pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8+ T cells (P<.0001; P=.014) than non‐pregnant women. HIV‐uninfected parturient women had fewer CD4+ and γδ T cells, B and NK cells (each P<.0001) than non‐pregnant women. Lymphocyte subset percentages were not affected by pregnancy.ConclusionMalawian women at parturition have an increased total white cell count due to neutrophilia and an HIV‐unrelated pan‐lymphopenia.

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Section: Discussionsupporting

confidence: 88%

Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women

Mandala

Gondwe

Molyneux

et al. 2017

American J Rep Immunol

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“…Regarding the relationship between thrombocytopenia and plasma HIV-RNA levels, however, reports are not consistent (6,25,31,(36)(37)(38). Similar to these findings, in our study, patients with thrombocytopenia had a significantly lower median CD4+ T lymphocyte count than the control group (P < 0.05), but the median plasma HIV-RNA levels were similar between the 2 groups (P > 0.05).…”

Section: Discussionsupporting

confidence: 53%

Prevalence and associated factors of thrombocytopenia among human immunodeficiency virus-infected patients at a tertiary care hospital in İzmir, Turkey

Hekimoğlu¹,

Kaptan²,

Vardar³

et al. 2017

Turk J Med Sci

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The aim of this study was to determine the prevalence and associated factors of thrombocytopenia in human immunodeficiency virus (HIV)-infected patients. Materials and methods:A cross-sectional study was conducted in a tertiary care hospital in İzmir, Turkey. All HIV-infected patients admitted to the Department of Infectious Diseases and Clinical Microbiology between 2006 and 2011 were recruited. Patients with thrombocytopenia at any time point were defined as the case group and the remaining patients were defined as the control group. Results:The frequency of thrombocytopenia was 35.8%. Thrombocytopenia was more frequent in patients with acquired immune deficiency syndrome (AIDS) than in patients without AIDS (P < 0.05) and in antiretroviral-naive patients than in patients on combination antiretroviral therapy (cART) or those who had ever used cART in the past (P < 0.05). Additionally, rates of tuberculosis infection, prophylactic use of trimethoprim-sulfamethoxazole (TMP/SMX), and being anti-HCV seropositive at any time point were higher in patients with thrombocytopenia than in the control group (P < 0.05), and the case group had lower CD4+ T lymphocytes at first admission (P < 0.05). Conclusion:The main finding was the clear association between thrombocytopenia and advanced and uncontrolled HIV infection. Tuberculosis and HCV coinfections were also identified as associated factors for thrombocytopenia.

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“…In different studies, the prevalence of anemia in individuals with AIDS has been reported at 63% to 95%, making it more common than thrombocytopenia or leukopenia in AIDS patients (6). Hematological abnormalities, mainly anemia and leukopenia, in antiretroviral-naive HIVinfected patients result in poor antiretroviral treatment outcome and otherwise strongly predict mortality (7,8). Our previous study (9) showed that anemia is highly prevalent among adults with newly diagnosed HIV/ AIDS in China.…”

Section: Introductionmentioning

confidence: 95%

A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS

Shen

Wang

et al. 2015

BST

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Hematological abnormalities in HIV-infected patients

Abstract: We found an association between CD4 count and hemoglobin level, neutrophil count, and platelet count, and that anemia was independently associated with a higher mortality.

Cited by 83 publications

References 26 publications

Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women

Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women

Prevalence and associated factors of thrombocytopenia among human immunodeficiency virus-infected patients at a tertiary care hospital in İzmir, Turkey

A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS

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