Hematological Abnormalities in Culture Positive Neonatal Sepsis

Adane, Tiruneh; Worku, Minichil; Tigabu, Abiye; Aynalem, Melak

doi:10.2147/phmt.s361188

Cited by 8 publications

(7 citation statements)

References 37 publications

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“…In terms of hematological changes, leucopenia (WBCs of <3,000/mm 3 ) was evident in 7.8% of infected neonates. This finding is similar to results reported by Adane et al 25 and Diakité et al 26 …”

Section: Discussionsupporting

confidence: 93%

Neonatal Group BStreptococcusinfection at a single center in Al-Madinah Al-Munawarah, Saudi Arabia

Surrati,

Alharbi,

Mohammedsaeed

et al. 2024

SMJ

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Objectives: To determine the occurrence of Group B Streptococcus (GBS) infection in neonates and its associated risk factors in Al-Madinah Al-Munawarah, Saudi Arabia. Methods: This retrospective study was carried out at the Maternity and Child Hospital in Al-Madinah Al-Munawarah, between 2017-2022. The laboratory and clinical data of 64 neonates were collected and analyzed using GraphPad Prism 7 software. Results: Out of 16,022 neonates admitted to the nursery, 64 infants were diagnosed with GBS infection. Approximately 53.1% were male, 46.9% female, 15.6% were preterm, and 84.4% were full-term. Vaginal births accounted for 71.9%. The mean onset age was 10±12.4 days. Among the GBS patients, 53.1% had early-onset disease (EOD, 0-6 days), while 46.9% had late-onset disease (LOD, 7-90 days). Unexamined mothers had a higher incidence of GBS and EOD newborns ( p =0.05). Meningitis was more common in LOD than EOD patients and correlated with illness onset ( p =0.05). Early-onset disease patients had a higher incidence of sepsis. The mortality rate was 10.9%, while 89.1% were discharged from the hospital. Conclusion: Neonatal GBS infection is prevalent in Al-Madinah Al-Munawarah. Several risk factors may contribute to the occurrence of GBS infection including preterm labor, higher body temperature during delivery, prolonged premature rupture of membranes for more than 18 hours, and GBS bacteriuria. We recommend that larger multi-centric studies are needed in Al-Madinah Al-Munawarah, to study the magnitude of neonatal GBS infection and risk factors to develop a screening protocol in maternity and children’s hospital.

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Section: Discussionsupporting

confidence: 93%

Neonatal Group BStreptococcusinfection at a single center in Al-Madinah Al-Munawarah, Saudi Arabia

Surrati,

Alharbi,

Mohammedsaeed

et al. 2024

SMJ

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“…PLT levels decreased by 17.0% in neonates with gram-positive septicaemia. 19 In addition, the results of this study show that there was no difference in MPV levels between the two groups in the early stage of infection; MPV levels increased in both groups during the recovery stage (compared with the early stage) and MPV/PLT ratios increased in the early stage. However, since MPV in the early stages of infection did not differ, multivariate logistic regression analysis showed that the MVP/PLT ratio is not an early predictor of severe neonatal infection; this result is inconsistent with the findings of related studies.…”

Section: Discussionmentioning

confidence: 56%

“… 18 The results of this study show that the probability of a decreased WBC level in severe neonatal infection is higher than the probability of an increased WBC level, which is consistent with the results of studies from other countries. 19 …”

Section: Discussionmentioning

confidence: 99%

An Analysis of Predictive Factors for Severe Neonatal Infection and the Construction of a Prediction Model

Wang¹,

Wang²,

Li³

2023

IDR

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Objective To investigate the primary predictive factors for the occurrence of severe neonatal infection, construct a prediction model and assess its effectiveness. Methods A total of 160 neonates hospitalised in the Department of Neonatology at Suixi County Hospital from January 2019 to June 2022 were retrospectively analysed. Clinical data was analyzed to determine the primary predictive factors for the occurrence of severe neonatal infection. Predictive efficacy was evaluated using a receiver operating characteristic curve, and a nomogram model was constructed according to the predictors. A bootstrap technique was used to verify the accuracy of the model. Results The neonates were divided, based on the degree of infection, into a mild infection group (n = 80) and a severe infection group (n = 80) according to a 1:1 ratio. Multivariate logistic regression analysis showed that compared with the recovery stage, white blood cell count (WBC) and platelet count (PLT) in the two groups were significantly decreased in the early stage of infection, and the ratio of mean platelet volume to PLT, as well as C-reactive protein (CRP) and procalcitonin levels, was elevated (P < 0.05). The area under the curves (AUCs) of decreased WBC, decreased PLT and elevated CRP levels, and the combination of these three indicators, were 0.881, 0.798, 0.523 and 0.914, respectively. According to the filtered indicators, two models (a dichotomous variable equation model and a nomogram model) of continuous numerical variables were constructed, and their AUCs were 0.958 and 0.914, respectively. The calibration curve of the nomogram model was validated with a consistency index of 0.908 (95% confidence interval [0.862, 0.954]). Conclusion Decreased WBC and PLT levels and an elevated CRP level were the primary independent predictors of severe neonatal infection.

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“…Additionally, anemia is a prevalent characteristic observed in the adult population during sepsis, resulting from iatrogenic blood loss, reduction in serum iron levels and erythropoietin synthesis, and a decrease in the lifespan of erythrocytes [35]. Regarding the neonatal population, a study by Adane et al showed that the prevalence of anemia in neonates with sepsis is 49% [36].…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin, Ferritin, and Lactate Dehydrogenase as Predictive Markers for Neonatal Sepsis

Lungu,

Popescu,

Manea

et al. 2024

JPM

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(1) Background: This study evaluates the predictive effectiveness of biomarkers in diagnosing newborn sepsis. (2) Methods: This was a case–control study conducted on neonates hospitalized at the Clinical Hospital “Louis Turcanu”, Timisoara, Romania, from October 2018 to July 2023. Using a vacutainer collection device, venous blood was collected at admission for complete blood tests, including ferritin, hemoglobin, LDH, and blood culture analysis. Neonates were divided into two groups: sepsis-positive and sepsis-negative. The outcome of interest was a diagnosis of sepsis. (3) Results: Data from 86 neonates, 51 of whom had been confirmed to have sepsis, were analyzed. This study found no significant difference in gestational age, infant weight, fetal growth restriction, or APGAR score between neonates with and without sepsis. However, there was a higher incidence of sepsis among neonates delivered via cesarean section. Neonatal patients with sepsis showed significantly higher levels of neonatal serum ferritin and LDH compared to those without sepsis. Ferritin and LDH biomarkers demonstrated excellent discriminatory capabilities in diagnosing neonatal sepsis. Logistic regression analysis revealed a significant association between elevated ferritin and LDH levels and the likelihood of neonatal sepsis, while anemia did not show a significant association. (4) Conclusions: LDH and ferritin concentrations are found to be predictive biomarkers for neonatal sepsis, indicating a potential role in detecting susceptible neonates and implementing prompt interventions to improve patient outcomes.

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Hematological Abnormalities in Culture Positive Neonatal Sepsis

Cited by 8 publications

References 37 publications

Neonatal Group BStreptococcusinfection at a single center in Al-Madinah Al-Munawarah, Saudi Arabia

Neonatal Group BStreptococcusinfection at a single center in Al-Madinah Al-Munawarah, Saudi Arabia

An Analysis of Predictive Factors for Severe Neonatal Infection and the Construction of a Prediction Model

Hemoglobin, Ferritin, and Lactate Dehydrogenase as Predictive Markers for Neonatal Sepsis

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