Hematological abnormalities and the use of granulocyte‐colony‐stimulating factor in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis

Abstract

Our patients tended to have leukopenia and neutropenia that followed a predictable trend of decline and subsequent improvement depending on the stage of disease. This may be of pathogenic significance, and G-CSF may be used in these cases to manage febrile neutropenia and aid re-epithelialization. Further basic science research is required to prove our hypotheses.

Comorbidity of Stevens–Johnson syndrome and neutropenia associated with lamotrigine: a case report

“…Based on the clinical course, we concluded that the SJS and leukopenia and/or neutropenia are associated with lamotrigine, and this is the first report to make this assertion. Though one case series study suggested that comorbidity between SJS and leukopenia and/or neutropenia is common (56%) [9], another such study demonstrated that leukopenia was not commonly observed with SJS, appearing in 2 of 29 cases (6.9%) [10]. Neither of these cases was associated with lamotrigine.…”

Toxic Epidermal Necrolysis (Lyell’s Syndrome)

“…В биохимическом анализе крови у 50% пациен-тов повышается уровень аминотрансфераз, ами-лазы, имеют место гипергликемия, гипопротеине-мия, повышается уровень мочевины и креатини-на, отмечается гипофосфатемия. В клиническом анализе крови -анемия, незначительный лей-коцитоз и лимфопения (за счёт снижения уровня CD4+ Т-лимфоцитов), у 30% пациентов отмечает-ся нейтропения, у 15% -тромбоцитопения [10].…”

Toxic epidermal necrolysis

“…This hypothesis should be examined in future studies. Neutropenia is generally associated with a higher mortality in SJS/TEN patients 41 .…”