Hematologic Toxicity in Patients Undergoing Radical Anti-cancer Therapy: A Cross-Sectional Analysis of Patients in an Oncology Ward in India

Roy, Soumyajit; Mallick, Supriya; Raza, M.; Haresh, K.P.; Gupta, Subhash; Sharma, Daya Nand; Julka, Pramod Kumar; Rath, Goura Kisore

doi:10.7314/apjcp.2014.15.8.3587

Cited by 2 publications

(2 citation statements)

References 12 publications

(11 reference statements)

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“…Nor Aziyan Yahaya 1 *, Pathmawathi Subramanian 1 , Anita Zarina Bustam 2 , Nur Aishah Taib 3 2012; Gunusen et al, 2013;Roy et al, 2014). Several studies have highlighted high prevalence rates of side effects during treatment (Walsh et al, 2000;Francoeur, 2005;Miaskowski et al, 2007).…”

Section: Symptom Experiences and Coping Strategies Among Multiethnic Solid Tumor Patients Undergoing Chemotherapy In Malaysiamentioning

confidence: 99%

Symptom Experiences and Coping Strategies among Multi-ethnic Solid Tumor Patients Undergoing Chemotherapy in Malaysia

Yahaya

Subramanian²,

Bustam³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: This study was performed to assess patient symptoms prevalence, frequency and severity, as well as distress and coping strategies used, and to identify the relationships between coping strategies and psychological and physical symptoms distress and demographic data of cancer patients. This cross-sectional descriptive study involved a total of 268 cancer patients with various types of cancer and chemotherapy identified in the oncology unit of an urban tertiary hospital. Materials and Methods: Data were collected using questionnaires (demographic questionnaire, Medical characteristics, Memorial Symptom Assessment Scale (MSAS) and Brief COPE scales and analyzed for demographic, and disease-related variable effects on symptom prevalence, severity, distress and coping strategies. Results: Symptom prevalence was relatively high and ranged from 14.9% for swelling of arms and legs to 88.1% for lack of energy. This latter was the highest rated symptom in the study. The level of distress was found to be low in three domains. Problem-focused coping strategies were found to be more commonly employed compared to emotion-focused strategies, demonstrating significant associations with sex, age group, educational levels and race. However, there was a positive correlation between emotion-focused strategies and physical and psychological distress, indicating that patients would choose emotion-focused strategies when symptom distress increased. Conclusions: These findings demonstrate that high symptom prevalence rates and coping strategies used render an improvement in current nursing management. Therefore development of symptoms management groups, encouraging the use of self-care diaries and enhancing the quality of psychooncology services provided are to be recommended.

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Section: Symptom Experiences and Coping Strategies Among Multiethnic Solid Tumor Patients Undergoing Chemotherapy In Malaysiamentioning

confidence: 99%

Symptom Experiences and Coping Strategies among Multi-ethnic Solid Tumor Patients Undergoing Chemotherapy in Malaysia

Yahaya

Subramanian²,

Bustam³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…The present study depicts the incidence and outcome of metabolic toxicities in cancer patients undergoing radical anti-cancer treatment, in a real world situation, in a developing nation. Although a number of publications [2][3][4] exist on hematological toxicities of anti-cancer treatment, literature on metabolic toxicities is sparse. Treatment of malignancies has taken a few long strides over the past two decades, however, it has unveiled newer challenges including different metabolic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Metabolic toxicities in patients undergoing treatment for nonhematological malignancy: A cross-sectional study

Gupta

Haresh

Roy

et al. 2016

Indian J Med Paediatr Oncol

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Objectives:The objective of this study was to evaluate the prevalence of metabolic toxicities in patients with different nonhematological malignancies admitted in oncology ward of a tertiary cancer care center while on treatment.Methods:We did this cross-sectional study over a period of 7 months (January–July 2013) for all adult patients (n = 280) who, while undergoing anti-cancer therapy at our center, got admitted to our oncology inpatient ward with metabolic toxicity. Grading of toxicity was done using National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.0.Results:A total of 46 events of metabolic toxicities were noted in 31 patients over this period. The most common of them was hyperglycemia (n = 10). The others were hypokalemia (n = 9), hyponatremia (n = 9), hypernatremia (n = 5), hyperkalemia (n = 5), tumor lysis syndrome (n = 4), hypercalcemia (n = 2), and grade ≤2 hypomagnesemia (n = 2). Majority of the patients were asymptomatic (n = 26). However, death occurred in five patients. Treatment interruptions took place in 19 patients. Age ≤40 years (P = 0.03), Eastern Cooperative Oncology Group performance status ≥2 (P = 0.023), history of addiction (P = 0.02), comorbidities (P = 0.037) were associated with increased risk of having metabolic toxicities on univariate analysis. While on multivariate analysis, only age, performance status, and history of addiction retained their statistical significance. Age ≤40 years (P = 0.02), use of more than one modality of treatment (P = 0.013), and hyperglycemia (P = 0.037) were associated with higher risk of death.Conclusion:Metabolic toxicities are common phenomena among cancer patients, especially those with young age, comorbidities, and having history of addictions. In young age, they might even be fatal, especially when they are treated with combined modality of treatment.

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Hematologic Toxicity in Patients Undergoing Radical Anti-cancer Therapy: A Cross-Sectional Analysis of Patients in an Oncology Ward in India

Cited by 2 publications

References 12 publications

Symptom Experiences and Coping Strategies among Multi-ethnic Solid Tumor Patients Undergoing Chemotherapy in Malaysia

Symptom Experiences and Coping Strategies among Multi-ethnic Solid Tumor Patients Undergoing Chemotherapy in Malaysia

Metabolic toxicities in patients undergoing treatment for nonhematological malignancy: A cross-sectional study

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