Hematologic parameters as predictive markers in pediatric Bell’s palsy

Cayir, Serkan; Kılıçaslan, Cengizhan

doi:10.1007/s00405-020-06459-w

Cited by 7 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that there is a correlation between high PLR and BP, and it has been suggested that microvascular ischemia plays a role in BP (18,20). Contrary to this view, many studies have reported that PLR does not increase BP (2,14,21). In our study, PLR was not found to be higher than the control group in our patients with BP.…”

Section: Resultscontrasting

confidence: 83%

“…The median clinical recovery time was 10 (3-90) days. The median clinical recovery time was 30 (10-90) days in boys and 7 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) days in girls, and the clinical recovery time was longer in boys (p=0.032). The hemogram parameters (leukocyte count, platelet count, neutrophil-lymphocytemonocyte percentage, RBC, Htc, Hb, MCV, RDW, MPV, NLR, MLR and PLR) of patients with Bell's palsy were similar to Lymphocytes direct immune system activity.…”

Section: Resultsmentioning

confidence: 97%

“…It has also been reported that MPV can be used as a negative acute phase reactant in chronic diseases (such as rheumatoid arthritis, and FMF) (23). MPV levels and BP has been investigated, but no correlation has been found (2,14,17,21). It has been theorized that BP may be an inflammatory condition rather than a microvascular event (17).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Hemogram Parameters of Children with Bell’s Palsy at the Time of Admission and Their Findings in the Follow-up

Sürücü Kara,

Arslan

2024

Türkiye Çocuk Hast Derg

View full text Add to dashboard Cite

Objective: The exact cause of idiopathic facial paralysis (Bell’s palsy) is not clear. The objective of our study was to investigate the relationship between certain hemogram parameters and the clinical prognosis in pediatric patients with facial paralysis. Material and Methods: The files of patients with Bell’s palsy under the age of 18 who applied to our hospital were evaluated retrospectively. Leukocyte, neutrophil, lymphocyte, platelet count, red cell distribution width, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio were compared between patients with Bell’s palsy and the control group. Information about their last health status recorded. Results: A total of seventeen children with Bell’s palsy and 17 control groups were included in the study. There were 7 boys (41.20%) and 10 girls (58.70%) in each group, the mean age was 11.80±4.40 (minimum 3.0-maximum 17.9) years. While the median neutrophil-lymphocyte ratio was 1.25 (0.41-7.63) in patients with Bell’s palsy and 1.40 (0.42-2.52) in the control group, the median mean platelet volume level was 9.30 fL (8.20-12.30) in patients with Bell’s palsy and 9.95 fL (9.30-11.70) in the control group, and the median red cell distribution width level was 12.75 % (11.50-26.30) in patients with Bell’s palsy and 12.70% (12.10-26.30) in the control group. None of them were statistically significant. There were six patients with Bell’s palsy with low mean platelet volume levels and no patients with low mean platelet volume levels in the control group (p=0.007). There was a positive correlation between the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio and the recovery time of patients with Bell’s palsy. Conclusion: Bell’s palsy may show a better prognosis in girls. High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio may be indicators of delayed recovery, inflammation, and microvascular ischemia in Bell’s palsy.

show abstract

Section: Resultscontrasting

confidence: 83%

Section: Resultsmentioning

confidence: 97%

See 1 more Smart Citation

Hemogram Parameters of Children with Bell’s Palsy at the Time of Admission and Their Findings in the Follow-up

Sürücü Kara,

Arslan

2024

Türkiye Çocuk Hast Derg

View full text Add to dashboard Cite

show abstract

“…Consistent with the evidence in the literature, significantly higher NLRs were identified in pediatric patients than in controls in a recent study. Furthermore, the authors postulated that the NLR was significantly higher in the non-recovery group than in the recovery group, which may indicate poor prognosis in pediatric BP patients [ 17 ]. According to the results obtained from the receiver operating characteristics analysis, it was determined that CAR (0.879) had higher area under the curve values than those of NLR (0.794).…”

Section: Prognostic Biomarkers In Apfpmentioning

confidence: 99%

Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy

Kim¹,

Yeo²,

Byun³

2021

IJMS

View full text Add to dashboard Cite

Acute peripheral facial palsy (APFP), including Bell’s palsy and Ramsay Hunt syndrome, is a disease that affects daily life through facial motor dysfunction, causing psychological problems. Various tests to evaluate prognosis have been studied; however, there are no validated predictive biomarkers to guide clinical decision making. Therefore, specific biomarkers that respond to treatment are required to understand prognostic outcomes. In this review, we discuss existing literature regarding the role of APFP biomarkers in prognosis and recovery. We searched the PubMed, EMBASE, and Cochrane Library databases for relevant papers. Our screening identified relevant studies and biomarkers correlating with the identification of predictive biomarkers. Only studies published between January 2000 and October 2021 were included. Our search identified 5835 abstracts, of which 35 were selected. All biomarker samples were obtained from blood and were used in the evaluation of disease severity and prognosis associated with recovery. These biomarkers have been effective prognostic or predictive factors under various conditions. Finally, we classified them into five categories. There is no consensus in the literature on the correlation between outcomes and prognostic factors for APFP. Furthermore, the correlation between hematologic laboratory values and APFP prognosis remains unclear. However, it is important to identify new methods for improving the accuracy of facial paralysis prognosis prediction. Therefore, we systematically evaluated prognostic and potentially predictive APFP biomarkers. Unfortunately, a predictive biomarker validating APFP prognosis remains unknown. More prospective studies are required to reveal and identify promising biomarkers providing accurate prognosis.

show abstract

“…About 90% of peripheral facial paralysis is idiopathic. Its pathogenesis is yet to be fully elucidated [ 1 ]. In many studies investigating the etiopathogenesis of Bell’s palsy, factors such as inflammation, viral infection, and microvascular insufficiency are seen to play a role.…”

Section: Introductionmentioning

confidence: 99%

Current Inflammatory Status of Monocyte Ratios in Bell’s Palsy

Serifler,

Gul,

Bulut

et al. 2024

Cureus

View full text Add to dashboard Cite

Objective: This study aims to investigate the contribution of monocyte/high-density lipoprotein (HDL) ratio (MHR) and monocyte/lymphocyte ratio (MLR) to the inflammatory process and the severity and prognosis of the disease in patients with Bell’s palsy. Materials and methods: The study was designed retrospectively by analyzing our electronic database. A study group consisted of 48 patients who were referred to our clinic with Bell’s palsy between January 2018 and June 2020. The control group consisted of 45 healthy individuals. Monocyte, HDL, neutrophil, lymphocyte, and platelet values were recorded. The hematological parameters obtained from the blood tests of the patients in the study group at the time of admission were statistically compared with the values in the control group. Radiologic images were also collected. Results: The MHR value of the study group was 12.85±1.02, while the MHR value of the control group was 12.29±1.33, and it showed a statistically significant difference (p=0.027). However, no statistically significant difference between the groups was found in other parameters, including MLR, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). A positive correlation was found between the MHR value and the House-Brackmann stage. The NLR value of the patients who showed contrast enhancement in facial nerves on MRI was found to be statistically significant compared to those without contrast enhancement. Conclusion: High MHR values in patients with Bell’s palsy support the role of inflammatory and ischemic processes in etiopathogenesis. Further studies are needed to confirm our results in a multi-center manner with larger patient populations.

show abstract

Hematologic parameters as predictive markers in pediatric Bell’s palsy

Cited by 7 publications

References 21 publications

Hemogram Parameters of Children with Bell’s Palsy at the Time of Admission and Their Findings in the Follow-up

Hemogram Parameters of Children with Bell’s Palsy at the Time of Admission and Their Findings in the Follow-up

Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy

Current Inflammatory Status of Monocyte Ratios in Bell’s Palsy

Contact Info

Product

Resources

About