Hematologic Disease

Hepner, David L.; Wilkins‐Haug, Louise; Marks, Peter

doi:10.1007/0-387-21572-7_22

Cited by 2 publications

(2 citation statements)

References 138 publications

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“…Reduced paternal antigen exposure such as nulliparity, shorter periods of sexual cohabitation, and changing paternity demonstrate increased risks for developing preeclampsia, indicating immunological contribution to the pathogenesis [20,21]. Some maternal conditions, such as advanced maternal age, obesity, diabetes mellitus, chronic hypertension, antiphospholipid syndrome (APS), chronic kidney disease (CKD), and systemic lupus erythematosus (SLE), are also associated with an increased risk of preeclampsia [1,2]. These maternal conditions have been reported to be associated with endothelial dysfunction, which may contribute to increased risk of preeclampsia [22].…”

Section: Diagnosis and Risk Factors Of Preeclampsiamentioning

confidence: 99%

“…Currently, the only effective treatment is termination of pregnancy, which may also add substantial risks to the neonate if the fetus is delivered prematurely. Although the clinical symptoms of preeclampsia completely resolve after delivery, recent evidence has demonstrated significant association between history of preeclampsia and future risks of cardiovascular diseases [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors

Tomimatsu

Mimura

Matsuzaki

et al. 2019

IJMS

174

106

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Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal morbidity and mortality. Maternal endothelial dysfunction caused by placental factors has long been accepted with respect to the pathophysiology of preeclampsia. Over the past decade, increased production of placental antiangiogenic factors has been identified as a placental factor leading to maternal endothelial dysfunction and systemic vascular dysfunction. This review summarizes the recent advances in understanding the molecular mechanisms of endothelial dysfunction caused by placental antiangiogenic factors, and the novel clinical strategies based on these discoveries.

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Section: Diagnosis and Risk Factors Of Preeclampsiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors

Tomimatsu

Mimura

Matsuzaki

et al. 2019

IJMS

174

106

View full text Add to dashboard Cite

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D Vitamini Seviyesi Preeklampsinin Şiddetini Değiştirir mi? Tek Merkezli Vaka Kontrol Çalışması

Demiroz

Ohanoglu

CEYLAN>³

et al. 2022

Medical Records

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Background: It is considered that preeclampsia and vitamin D deficiency may be a cause. Aim: We aimed to investigate the association between vitamin D deficiency and severity of preeclampsia. Study Desing: Case-Control Study Methods: We conducted a case-control study aiming to evaluate vitamin D serum levels in patients with preeclampsia(PE), severe preeclampsia, eclampsia and HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets). Total number of 69 patients between the ages of 18 and 40 either had a spontaneous vaginal delivery or C-section were included in the study. Results: The demographic data of the patients were similar, and age was higher in severe PE than in the other groups. When body mass index (BMI) was evaluated, the average BMI of the patients in the severe PE group was found to be significantly higher than PE and similar to the other groups. The average vitamin D levels of all groups was 8.75 ± 3.5 and the mean of severe PE was 6.69 ± 3, which was significantly lower than the other groups. The average vitamin D level in PE was 10.99 ± 2.91, and it was higher than all groups and was significantly higher than patients with severe PE and HELLP syndrome. Conclusion: We think that there is a significant relationship between the severity of hypertensive disorders that begin during pregnancy and the degree of vitamin D deficiency. We think that the control of vitamin D level and its addition to the treatment will positively affect the course of the disease in order to prevent hypertensive disorders and reduce the severity of disease.

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Hematologic Disease

Cited by 2 publications

References 138 publications

Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors

Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors

D Vitamini Seviyesi Preeklampsinin Şiddetini Değiştirir mi? Tek Merkezli Vaka Kontrol Çalışması

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