Hematologic alterations and CO2 hypersensitivity in male panic disorder patients and normal controls: Similarities to high-altitude hypoxia and chronic lung disease

Levels of basophils and eosinophils are elevated while lymphocytes are reduced in patients with panic disorder compared to controls: a preliminary study

“…Consequently, we consider that our present findings revealing that the basophil, eosinophil, and lymphocyte values of the patients were significantly lower when compared to those of healthy subjects support the relationship between panic disorder and comorbid immunological and allergic diseases. On the other hand, we are in accordance with the Ross et al's comments indicating that hypersensitive suffocation alarm system aforementioned might erroneously affect haematological changes, maladaptive to the real environment [11]. It has been reported that glucocorticoid levels, especially in patients who withdrew from steroid treatment, are closely related to depression, suicidal behavior, and panic disorder [27].…”

“…With regard to the alteration of the haematological parameters in panic disorder, first efforts began with the thought that the patients with panic disorder may have a hypersensitive alarm system which cause to a pathologic exaggerated reaction to physiologic signs of potential suffocation which can affect patients' haematological parameters [10]. Ross et al examined haematological indices in patients with panic disorder and healthy controls, with the hypothesis that hypersensitive suffocation alarm system aforementioned might erroneously affect haematological changes, maladaptive to the real environment [11]. Resembling the subjects with chronic obstructive pulmonary disease or high-altitude dwellers, they found that MCH might be relatively increased.…”

“…First efforts start with the notion that the patients with panic disorder may have a hypersensitive alarm system which causes to a pathologic exaggerated reaction to physiologic signs of potential suffocation which can affect patients' haematological parameters [10]. In this context, Ross et al [11] examined haematological indices in the patient with panic disorder patients and healthy controls, with the hypothesis that hypersensitive suffocation alarm system aforementioned might erroneously affect haematological changes, maladaptive to the real environment, and found that MCH might be relatively increased. On the other hand, the panic disorder itself is reported to be related to a high frequency of comorbid immunological diseases such as type I allergy and obstructive lung disorders like asthma [12,13].…”