Hematologic abnormalities in rheumatoid arthritis

Mowat, A G

doi:10.1016/0049-0172(72)90001-7

Cited by 96 publications

(53 citation statements)

References 66 publications

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“…The two most common explanations are gastrointestinal blood loss due to anti-inflammatory drugs and bone marrow changes in patients with inflammatory arthritis, which prevents the release of iron for incorporation into red blood cells (Mowat, 1971;Allar et al, 1977). In our study, control rats showed a reduced RBC count.…”

Section: Discussionmentioning

confidence: 59%

Acute and Subacute Anti-Inflammatory Activities of Dichloromethane Extract of Cassia Alata (Linn.) Leaves in Wistar Rats

F.L¹,

A.B²,

G.R³

et al. 2017

AJTCAM

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Background: In Burkina Faso, leaves of Cassia alata are used in the treatment of several diseases, including inflammation. This study evaluated the anti-inflammatory effects of the dichloromethane extract of Cassia alata leaves (CF-AECal) on different models of inflammation in wistar rats in order to enhance its use in traditional medicine. Materials and Methods: Acute inflammation was induced among rats with 0.1 ml of carrageenan, serotonin, histamine and dextrane 1%. The effects of the CF-AECal 50 mg/kg and 100 mg/kg were compared to the effects of diclofenal 5 mg/kg, prednisone 5 mg/kg, promethazine 1 mg/kg, cyproheptadin 2 mg/kg. Cotton pellet and air pouchinduced granuloma permitted to study CF-AECal effects on the subacute inflammation. The ways of administrations were intra peritoneal for the substances of inductions and oral for the molecules of references and CF-AECal. Result: Carrageenan-induced paw edema has been inhibited to 52.39% by CF-AECal 50 mg/kg and 50.17% by CFAECal 100 mg/kg. Wet granulomas formation has been inhibited by CF-AECal 50 and 100 mg/kg to 20.94 and 57.82%. The dry granulomas were inhibited at 24.32 and 59.04% by CF-AECal 50 and 100 mg/kg. Air pouch fluid was significantly reduced by CF-AECal in comparison to the control group. There was a massive recruitment of leukocytes in the pocket granuloma of the control group. CF-AECal caused strong inhibition of this infiltration of leukocytes (p< 0.001). Conclusion: Dichloromethane extract of Cassia alata showed anti-inflammatory effects.

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Section: Discussionmentioning

confidence: 59%

Acute and Subacute Anti-Inflammatory Activities of Dichloromethane Extract of Cassia Alata (Linn.) Leaves in Wistar Rats

F.L¹,

A.B²,

G.R³

et al. 2017

AJTCAM

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“…Although the anemia in RA is characterized by a slightly increased rate of erythrocyte pro duction (21), results measuring serum EPO titers in RA have been conflicting (8,9,22,23). The serum EPO level measured by RIA in rats with AA was found to be significantly increased in accordance with the increased re ticulocyte count (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Mild to moderate anemia is frequently seen in chronic inflammation, including active rheumatoid arthritis (RA) (8,9); the patho genesis or the response of this anemia to r-HuEPO is a matter of controversy (10). Ex perimental adjuvant-induced polyarthritis in the rat shares certain features with human RA, morphologically and therapeutically (11,12).…”

mentioning

confidence: 99%

Recombinant Human Erythropoietin, but Not Iron Supplementation, Improved Anemia in Rats with Adjuvant-Induced Arthritis.

Asai¹,

Oshima²

1991

Jpn.J.Pharmacol

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ABSTRACT-Pathophysiological and therapeutic properties of anemia in rats with adjuvant-induced arthritis (AA) were investigated. Both anemia and chronic in flammation were induced in rats by a single injection of Freund's complete adjuvant. This study confirmed other earlier data that these anemic rats with AA had reduced serum iron levels and that the anemia was characterized as mild, non-progressive, hypochromic, microcytic. In addition, our studies showed that these anemic rats had slightly but significantly enhanced erythropoietin titers, but not renal failure; there was no significant difference in blood urea nitrogen and creatinine levels in anemic and normal groups. The anemia in rats with AA was improved by recombinant hu man erythropoietin (r-HuEPO) at 30 and 100 U/kg/day, given i.v. for 5 days. In con trast, iron-chondroitinsulfate colloid (10 mg/kg/day, i.v. for 5 days) failed to improve the anemia and to enhance the effects of r-HuEPO. These data suggest that anemia in rats with adjuvant-induced arthritis is distinguished, pathophysiologically and thera peutically, from iron deficiency anemia, hemolytic anemia, and renal anemia.

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“…Таким образом, на основании полученных результатов можно сделать обоснованный вывод о более тяжелом течении РА у больных с анемией, что согласуется с данными ранее опубликованных работ [10,11,12,13,14,15].…”

Section: результаты и обсуждениеunclassified

“…Ассоциация синдрома анемии с более тяжелым течением ревматоидного артрита (РА) отмечается в целом ряде исследований, посвященных изучению данного заболевания [10,11,12,13,14,15]. Однако в изучении этого феномена имеется много недоста точно, а зачастую вообще не исследованных аспек тов, требующих проведения специального анализа.…”

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Relationship of anemia with clinicolaboratory measures of inflammation activity in patients with rheumatoid arthritis

Sizikov¹,

Гельфгат²,

Коненкова³

et al. 2007

rsp

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Hematologic abnormalities in rheumatoid arthritis

Cited by 96 publications

References 66 publications

Acute and Subacute Anti-Inflammatory Activities of Dichloromethane Extract of Cassia Alata (Linn.) Leaves in Wistar Rats

Acute and Subacute Anti-Inflammatory Activities of Dichloromethane Extract of Cassia Alata (Linn.) Leaves in Wistar Rats

Recombinant Human Erythropoietin, but Not Iron Supplementation, Improved Anemia in Rats with Adjuvant-Induced Arthritis.

Relationship of anemia with clinicolaboratory measures of inflammation activity in patients with rheumatoid arthritis

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