Hematogenous metastases in patients with Stage I or II endometrial carcinoma

Blecharz, Paweł; Urbański, Krzysztof; Mucha-Małecka, Anna; Małecki, Krzysztof; Reinfuss, Marian; Jakubowicz, Jerzy; Skotnicki, Piotr

doi:10.1007/s00066-011-2250-6

Cited by 13 publications

(17 citation statements)

References 53 publications

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“…There are several patterns of metastatic spread from EC, including intra‐abdominal spread and lymph node involvement; however, distant organ metastasis involving the lungs, liver, brain, or bone is considered a unique situation . Although distant organ metastasis is a rare event in EC, it has important implications and is associated with substantially shortened survival . Moreover, the specific site of distant metastasis can influence survival for women with EC, and it is important to understand the patterns of metastasis in newly diagnosed cases in order to more accurately predict prognosis and select an appropriate management strategy.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5] Although distant organ metastasis is a rare event in EC, it has important implications and is associated with substantially shortened survival. 6,7 Moreover, the specific site of distant metastasis can influence survival for women with EC, and it is important to understand the patterns of metastasis in newly diagnosed cases in order to more accurately predict prognosis and select an appropriate management strategy.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

Liu

Chi

Zhou

et al. 2020

Intl J Gynecology & Obste

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Objective To evaluate the prognosis of women with distant metastasis at the time of endometrial cancer (EC) diagnosis and identify prognostic factors according to metastatic site. Methods A retrospective cohort study of women diagnosed with EC according to the SEER database between 2010 and 2014. Univariate and multivariate Cox regression was used to identify variables associated with overall survival. Kaplan‐Meier curves were used to compare survival among different groups. Results Overall, 2948 women with stage IV EC were identified. The most common distant metastatic site was the lung. Having a distant metastatic site independently predicted overall survival. Using brain metastasis as a reference, overall survival was longer for liver (P=0.049), lung (P=0.005), and bone (P=0.019) metastasis. Relative to no distant metastasis, overall survival was shorter for women with one (P<0.001) or two or more (P<0.001) sites of distant metastasis. Overall survival was independently influenced by tumor grade, insurance status, and surgery among women with only lung metastasis. Conclusion The findings showed that the prognosis of women with stage IV EC differs by distant metastatic site, and identified several predictors of poor survival. They may help clinicians to better predict prognosis for newly diagnosed cases of EC with distant metastasis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

Liu

Chi

Zhou

et al. 2020

Intl J Gynecology & Obste

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“…These diseases exhibit a significant potential for distant metastases, even at early stages, as evidenced by the identification of bone metastases in cervical cancer patients with suspected clinical stage 2B disease. In a study of hematogenous metastases in patients with FIGO Stage 1 or 2 endometrial carcinoma, 134 metastatic sites were identified in a total of 110 patients, and bone involvement was observed in 23 patients [16]. …”

Section: Discussionmentioning

confidence: 99%

Can surgical management of bone metastases improve quality of life among women with gynecologic cancer?

Eskander

Wang

et al. 2014

World J Surg Onc

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BackgroundThe evaluation, counseling, and management of gynecologic patients with bone metastasis remain a challenge for clinicians. In order to critically evaluate the role of surgery, we retrospectively analyzed the records of 18 patients surgically treated for metastatic gynecologic tumors of bone, focusing on quality of life, local tumor control, and survival.MethodsEighteen patients underwent surgical procedures for the treatment of bone metastases secondary to gynecologic cancer between September 2003 and April 2012. The primary cancer sites included the uterus (n = 10), the cervix (n = 5), and an ovary (n = 3). Patients were followed for an average period of 13.8 months (range, 2 to 34 months). A visual analog pain scale (VAS) and Eastern Cooperative Oncology Group (ECOG) performance status were evaluated both pre- and postoperatively.ResultsThe median survival time following diagnosis of bone metastasis was 10.0 months. The mean VAS score was 5.8 preoperatively compared with 2.1, 3 months after surgery. The mean pre and postoperative ECOG performance status grades were 3.1 and 2.3, respectively.ConclusionsThe prognosis of gynecological cancer patients with bone metastasis is poor. Some patients had improvement in their quality of life after surgical intervention for bone metastases; however, novel integrated treatment modalities should be investigated.

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“…Hysterectomy and bilateral salpingo-oophorectomy alone or in association with pelvic and para-aortic lymphadenectomy allow a successful treatment in a majority of cases, depending on the stage of the disease. In the event of poor prognostic factors, adjuvant therapies, such as chemotherapy and/or radiotherapy, are associated to surgery [14,15]. Even though some evidence suggests that age is not an independent prognostic factor, older patients seem to present a poorer prognosis.…”

Section: Treatment Of Advanced Ecmentioning

confidence: 99%

Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma

Bogliolo

Gardella

Dominoni

et al. 2015

Arch Gynecol Obstet

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Hematogenous metastases in patients with Stage I or II endometrial carcinoma

Cited by 13 publications

References 53 publications

Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

Can surgical management of bone metastases improve quality of life among women with gynecologic cancer?

Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma

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