Hematocrit Interference of Blood Glucose Meters for Patient Self-Measurement

Determination of Hematocrit Interference in Blood Samples Derived from Patients with Different Blood Glucose Concentrations

“…It is calculated by adding the highest observed mean deviation over the entire glucose range above the 45% result to the highest absolute deviation below the 45% result, as described previously. 10,12 The result and ranking of the devices based on this parameter is provided in Figure 3. An HIF <15% for the individual glucose level and a mean HIF over the entire glucose ranges <0% was defined as indicative for no clinically relevant influence of HCT on the BG readings.…”

“…21 Recently, a first thorough investigation of the HCT distribution in an urban community has been published demonstrating a range 30-50% in Using artificially produced samples in a laboratory setting, we have been able to demonstrate that devices employing dynamic electrochemistry are unaffected by HCT variation. 10,12 Laboratory tests with devices employing dynamic electrochemistry, however, require an extremely careful handling of the sample. The composition of whole blood samples deteriorates with aggressive centrifugation or vigorous shaking of samples as requested by many laboratory protocols applied during sample preparation for proficiency testing of BG meters.…”

“…10−12 Technical solutions to correct for possible HCT interference include the parallel measurement of HCT with a subsequent correction algorithm as employed by point-of-care devices and handheld patient meters employing the same technology. 10,11 Another solution is the application of a physical and mathematical algorithm derived from a dynamic electrochemistry approach as employed by BGStar ® and iBGStar ® (Sanofi, Frankfurt, Germany). Dynamic electrochemistry involves making multiple measurements at different conditions (e.g., by varying frequencies and voltage) and readjusting the input stimulation signal in response to how the electron transfer kinetics at the electrode and the related chemistry is progressing.…”

Histogram analysis for smartphone-based rapid hematocrit determination

“…The normal hematocrit-level is considered as rather constant, and it is in the range of 40% to 54% for adult males and 37% to 47% for adult women [3][4][5]. The inconsistency of a hematocrit from its reference levels is generally regarded as the sign of a critical disease such as anemia, leukemia, a kidney infection, or a diet deficiency; or, it could be the indication of an unambiguous condition, such as pregnancy, or even extensive exercise [2,6,7]. A blood hematocrit in the range of 10% to 45% favors the screening of or the extension of a person's anemia; that is, a low hematocrit less than the normal range indicates an anemia or a diseased body.…”

“…The interference of a blood hematocrit is usually considered as a potentially important issue by many health-care professionals [1,2]. The normal hematocrit-level is considered as rather constant, and it is in the range of 40% to 54% for adult males and 37% to 47% for adult women [3][4][5].…”