Hematobiochemical changes of lead Poisoning and amelioration with Coconut (&lt;i&gt;Cocos nucifera&lt;/i&gt; L.) Water in wistar albino rats

Jesuorsemwen, Enagbonma Ben; Ebikere, Iyorah Imeda; Ozede, Igiehon Nicholas; Eghomwanre, Aimuanmwosa Frank

doi:10.4314/jasem.v20i1.11

Cited by 6 publications

(7 citation statements)

References 19 publications

(24 reference statements)

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“…There was a significant decrease in hematological parameters like TEC, Hb, and PCV in lead treated rats, where as TLC values were increased compared to control group. These findings were in agreement with [8,11] . Hematological changes might be attributed to the toxic effect of lead on cell metabolism, interaction with calcium as secondary mediator and inhibition of enzymatic activities such as aminolevulinic acid dehydratase which play key role of heme biosynthesis and other erythrocyte enzymes [3] .…”

Section: Resultssupporting

confidence: 93%

Hemato-biochemical and anti-oxidant changes induced by lead and cadmium alone and combined exposure in male wistar rats

Ramesh¹,

Madhuri²,

Lakshman³

et al. 2018

Int. J. Clin. Diagn. Pathol.

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Lead and cadmium are most life threatening environmental pollutants nowadays due to increased industrialization. This study was carried out to study alteration in hematological and biochemical changes induced by lead and cadmium alone and in combination on rats. Forty two male albino Wistar rats were divided into 4 groups 12 rats in each group; group 1 (control) was given deionized water, group 2 (lead group) was given water with lead acetate @ 30 mg/kgb. wt, group 3 (cadmium group) was given water with cadmium chloride @15 mg/kgb. wt, group 4 (combined group) was given water with both lead acetate @ 30 mg/kgb. wt and cadmium chloride @15 mg/kgb. wt for 28 days. Hematobiochemical parameters were analyzed at 14 th day and 28 th day. Results showed a significant decrease in TEC, Hb and PCV where as TLC count was increased in toxic groups i.e group 2, 3 and 4 when compared to control. There was a significant elevated levels of biochemical parameters AST, ALT, ALP and decreased total protein indicating liver dysfunction. Increased levels of BUN and creatinine noticed in toxic groups indicated renal dysfunction. Anti-oxidant profile showed decreased GSH and increased TBARS in liver and kidney tissue in toxic groups indicating oxidant injury.

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Section: Resultssupporting

confidence: 93%

Hemato-biochemical and anti-oxidant changes induced by lead and cadmium alone and combined exposure in male wistar rats

Ramesh¹,

Madhuri²,

Lakshman³

et al. 2018

Int. J. Clin. Diagn. Pathol.

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“…Platelet level was decreased in rats treated with C. papaya leaves [52]. This finding however contrasts a research conducted by Enagbonma et al [48] who reported that following the administration of 0.10mg/kg of lead to albino rats, the platelet levels reduced when compared to the control. Sule et al [51], reported that the levels of lymphocytes increased in rats pretreated with Carica papaya when compared with rats administered with CCl4 only.…”

Section: Discussioncontrasting

confidence: 61%

“…Jassim and Hassan [47], also reported that lead acetate when given orally to female rats at a dose of 10 mg/kg produced significant increase in percentage of WBC count and MCV. In contrast, a research conducted by Enagbonma et al [48] revealed that when 0.10mg/kg of lead was administered to albino rats, the RBC levels reduced when compared to the control. This could be due to the difference in dosage of lead administered.…”

Section: Discussionmentioning

confidence: 77%

“…Terayama [45], Al-Saleh [53], Enagbonma et al [48], Orji et al [49] and Savithri et al [54] all reported that exposure to lead significantly decreased RBC counts values and Hb in rats but when C. papaya leaf extract was administered to albino wistar rats, there was a significant increase in the RBC and Hb levels. The decreased RBC in the lead treated group could be as a result of iron deficiency anemia, bone marrow disorder and chronic inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Carica papaya Leaves and Seeds on Electrolyte and Hematological Parameters in Albino Wistar Rats Exposed to Lead Nitrate

Okon

Aluko

Okon

et al. 2023

AJBGMB

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Background: Exposure to lead produces a variety of adverse health effects. This study evaluated the effect of aqueous extracts of Carica papaya leaves and seeds on electrolyte and hematological parameters in albino Wistar rats exposed to lead nitrate. Methods: Thirty male albino Wistar rats weighing between 174- 196g were assigned to six groups of five animals. Group 1 served as control, group 2 received 50mg/kg body weight lead nitrate (PbNO3), groups 3 and 4 received 500 mg/kg body weight aqueous extract of Carica papaya leaves (CPL) and Carica papaya seed (CPS) respectively, groups 5 and 6 received 50mg/kg body weight PbNO3 + 500mg/kg body weight CPL and CPS respectively for 31 days by oral gavaging. Animals were sacrificed and blood collected for various assay using standard methods. ANOVA on SPSS version 25 was used to determine variations within and between groups. Results: Increases in sodium and potassium, and decreases in chloride, calcium and bicarbonate levels were observed in the lead intoxicated group. Treatment with CPL and CPS reversed the alterations in electrolytes. Levels of RBC, PCV, Hb, MCH, MCHC and lymphocytes were lower in the lead intoxicated group relative to the lead intoxicated groups complemented with CPL and CPS, while WBC, MCV and platelet counts were higher in the lead intoxicated group when compared to the group complemented with CPL and CPS. Conclusion: This finding suggests that CPL and CPS could be protective against lead induced alterations in electrolytes and hematological parameters and could be harnessed for these potentials.

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“…11 Tender coconut water to prevent oxidative stress, reduce free radicals, increase Antioxidant Enzym, decrease lipid peroxidative. 7,11,[22][23][24] The result of this study indicate that tender coconut water at a dose of 8 mL/200 gBW is significantly increased hemoglobin, hematocrit and erythrocyte levels in male wistar strain rats induced by Pb, these results are linear with previous research by Jesuorsemwen et al that the mean hematocrit and erythrocyte levels increased in the administration of tender coconut water, 25 the results of other research conducted by Safitri et al stated that the administration of tender coconut water can increase the mean of blood hemoglobin level. 26 Fa'iza et al stated that there were differences in blood Hemoglobin level before and after consumption of green coconut water in workers exposed to lead (Pb) with p value = 0.001.…”

Section: Discussionmentioning

confidence: 99%

Effect of Tender Coconut Water to Prevent Anemia on Wistar Rats Induced by Lead (Plumbum)

Zulaikhah¹,

Wahyuwibowo²,

D³

et al. 2019

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Background: Tender coconut water (TCW) is a nutritious healthy drink, some content as L-arginin, iron, vitamin C, vitamin B6, folic acid and fatty acid have roles during the process of blood formation (hematopoesis). Lead (Pb) is one of heavy metal which can trigger the formation of Reactive Oxygen Species (ROS), causing oxidative stress and hematopoetic stem cell disorders which cause the decrease of hematocrit, hemoglobin and erythrocyte levels as the sign of anemia. Aim and Objectives: This research to investigate the effect of tender coconut water to prevent anemia on lead induced rats. Material and Methods: Experimental research by post test only control group design, using 18 white wistar strain male rats randomly divided into 3 groups. Group K1 served as control, Group K2 was fed lead (10 mg/day/rat), Group K3 was given tender coconut water (8 mL/200gr BW rats/ day) orally for four weeks. Rats' blood from ophtalmicus venous was analyzed using Hematology Analyzer to measure the hemoglobin, hematocrit, and erythrocyte levels. Data were analyzed using Anova test and Kruskal Wallis. Results:That decreased levels of hematocrit, hemoglobin and erythrocyte were show in group K2 compared with group K1. Increased levels of hematocrit, hemoglobin and erythrocyte were observed significantly in both groups K3 than K2. Conclusion: Results of the present study have administration of tender coconut water (8 mL/200gr BW rats/ day for 4 weeks) could increased of hematocrit, hemoglobin and erythrocyte levels (p <0.05). The administration of tender coconut water has proven to prevent the anemia indicated by the increase of hematocrit, hemoglobin and erythrocyte levels on wistar strain male rats induced by lead.

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Hematobiochemical changes of lead Poisoning and amelioration with Coconut (<i>Cocos nucifera</i> L.) Water in wistar albino rats

Abstract: ABSTRACT:To determine the ameliorative effect of coconut water on haematobiochemical changes due to lead poisoning in wistar albino rats for six weeks, sixty rats were assigned to four groups. 0.10g/l of lead and 75ml coconut (cocus nucifera l.) water were given orally for six weeks.

Cited by 6 publications

References 19 publications

Hemato-biochemical and anti-oxidant changes induced by lead and cadmium alone and combined exposure in male wistar rats

Hemato-biochemical and anti-oxidant changes induced by lead and cadmium alone and combined exposure in male wistar rats

Effect of Carica papaya Leaves and Seeds on Electrolyte and Hematological Parameters in Albino Wistar Rats Exposed to Lead Nitrate

Effect of Tender Coconut Water to Prevent Anemia on Wistar Rats Induced by Lead (Plumbum)

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