Hemangiopericytoma of the uterus: Report of a case with a comprehensive review of the literature

Sooriyaarachchi, Gamini S.; Ramírez, Guillermo; Roley, Everett L.

doi:10.1002/jso.2930100504

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…Diffuse desmin and h-caldesmon positivity excludes an endometrial stromal neoplasm. 18 In the older literature, there have been several reports of uterine hemangiopericytoma 19 ; these neoplasms were characterized by a staghorn vascular pattern. It is likely that most if not all of these reports represent examples of endometrial stromal neoplasm with a prominent vascular pattern.…”

Section: Discussionmentioning

confidence: 99%

Uterine Angioleiomyomas: A Report of 3 Cases of a Distinctive Benign Leiomyoma Variant

McCluggage

Boyde

2007

Int J Surg Pathol

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We report 3 cases of a distinctive uterine leiomyoma containing numerous thick-walled vascular channels, which we term angioleiomyoma. The leiomyomas occurred in women aged 33, 44, and 49 and ranged from 1.5 to 6.0 cm. They were composed of bland, spindle-shaped cells with numerous evenly distributed, arteriole-like vessels with thick muscular walls throughout. The spindle cells often swirled around the vessels. In 1 case, fibrin was present within vessel walls. The spindle cells were positive with smooth-muscle markers and negative with HMB45. We believe angioleiomyoma should be recognized as a distinct entity and included in the World Health Organization classification of tumors of the female genital tract as a benign leiomyoma variant, similar to cellular and atypical leiomyoma. Uterine angioleiomyoma has a close morphological resemblance to the similarly named skin tumor. We review uterine smooth-muscle and other mesenchymal neoplasms in which prominent vascular channels are a feature.

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Section: Discussionmentioning

confidence: 99%

Uterine Angioleiomyomas: A Report of 3 Cases of a Distinctive Benign Leiomyoma Variant

McCluggage

Boyde

2007

Int J Surg Pathol

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“…It is now generally accepted that most uterine hemangiopericytomas reported in the literature probably represented examples of endometrial stromal tumors. [8][9][10] With late recurrences and metastasis in unusual locations and varied histology, the differential diagnosis of metastatic endometrial stromal sarcoma is wide and includes several soft-tissue neoplasms demonstrating arborizing vasculature. With the intent of distinguishing endometrial stromal sarcoma from soft-tissue neoplasms demonstrating 'hemangiopericytomatous' vascular patterns, we studied 55 cases of endometrial stromal sarcoma, solitary fibrous tumor, hemangiopericytoma, and synovial sarcoma using a battery of commonly used immunohistochemical stains-anti-CD10, anti-estrogen receptor (ER), anti-progesterone receptor (PR), anti-bcl-2, anti-CD34, anti-smooth muscle antigen (SMA), anti-epithelial membrane antigen (EMA), and AE1/ AE3 cytokeratin.…”

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confidence: 99%

Distinction of endometrial stromal sarcomas from ‘hemangiopericytomatous’ tumors using a panel of immunohistochemical stains

et al. 2005

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Endometrial stromal sarcomas are low-grade malignant tumors that may pose a diagnostic challenge, especially when they are present in an extrauterine site. Owing to the presence of an arborizing vasculature and cells with an undifferentiated appearance, endometrial stromal sarcomas can be confused with several softtissue neoplasms. We studied 17 endometrial stromal sarcomas, eight hemangiopericytomas, 14 solitary fibrous tumors, and 16 synovial sarcomas immunohistochemically, detecting the following antigens: CD10, estrogen receptor, progesterone receptor, bcl-2, CD34, smooth muscle antigen, epithelial membrane antigen and cytokeratin (AE1/AE3). Most endometrial stromal sarcomas stained positively for CD10 (16/17), estrogen receptor (17/17), progesterone receptor (15/17), and bcl-2 (17/17). Staining with antismooth muscle antigen was seen in 11 of 17 cases of endometrial stromal sarcoma, with more intense staining seen in areas showing smooth muscle differentiation. Staining with AE1/3 was seen in four of 17 endometrial stromal sarcomas, with two of the positive cases containing epithelioid cells. None of the endometrial stromal sarcomas expressed epithelial membrane antigen or CD34. More than half of the hemangiopericytomas (4/8) and solitary fibrous tumors (9/14) cases demonstrated CD10 expression either focally or in a patchy cytoplasmic and membranous pattern. Hemangiopericytomas, solitary fibrous tumors, and synovial sarcomas did not express estrogen receptor. Four of eight hemangiopericytomas and seven of 14 solitary fibrous tumors also showed patchy progesterone receptor expression. CD34 expression was identified in six of eight hemangiopericytomas and 13 of 14 solitary fibrous tumors, but we did not find expression of CD34 in synovial sarcoma. Differences between endometrial stromal sarcoma and other soft-tissue tumors were detected for all of the immunohistochemical markers (Po0.05), except anti-bcl-2 and AE1/3. Antibodies against CD10 mark a substantial number of hemangiopericytomas and solitary fibrous tumors (albeit not diffusely) and should always be combined with antiestrogen receptor and CD34 when the differential diagnosis includes endometrial stromal sarcoma. Unlike estrogen receptor antibodies, progesterone receptor antibodies show at least focal nuclear staining in most hemangiopericytomas, solitary fibrous tumors and rare synovial sarcomas, and are not useful for this differential diagnosis. All endometrial stromal sarcomas expressed bcl-2, mostly in a diffuse pattern, but this did not distinguish between endometrial stromal sarcoma and mimics. We therefore recommend the use of a small antibody panel comprising anti-CD10, anti-estrogen receptor, and anti-CD34 to distinguish endometrial stromal sarcomas from tumors with a predominant hemangiopericytomatous growth pattern. 3 Several morphologic variants of endometrial stromal sarcoma have been described; they include those with fibromyxoid features and those showing smooth muscle, fibroblastic, and epithelial differentiation, which

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“…Several authors (1, 3, 7) find that 50% of the tumors become malignant. They recur mainly locally and metastasize mostly through the blood stream (1,3,7,8). Recurrences may occur many years later.…”

Section: Discussionmentioning

confidence: 99%

“…contractile cells spiralling about the capillaries. Hemangiopericytomas occur in benign, malignant and borderline forms (7), localized mostly to the extremities or in the retroperitoneum, but there are reports of uterine origin (8). Primary hemangiopericytoma localized to the ovaries does not appear to have been described previously.…”

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confidence: 99%

Malignant Hemangiopericytoma of the Ovary

Nørgaard

Hansborg

Fischer-Rasmussen

1985

Acta Obstet Gynecol Scand

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Tumors originating from the blood vessels seldom occur in the ovaries, and primary hemangiopericytoma localized to the ovaries has not previously been described. In the case reported here a bilateral ovarian tumor was found, with one metastasis to the terminal ileum. It was not possible to perform a radical operation, and the patient was after-treated with external irradiation therapy and chemotherapy. For 9 1/2 months the tumor receded, whereafter it appeared to be stationary for 13 months, to the death of the patient. At autopsy the tumor was in evident regression and there were no signs of metastases.

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Hemangiopericytoma of the uterus: Report of a case with a comprehensive review of the literature

Cited by 10 publications

References 26 publications

Uterine Angioleiomyomas: A Report of 3 Cases of a Distinctive Benign Leiomyoma Variant

Uterine Angioleiomyomas: A Report of 3 Cases of a Distinctive Benign Leiomyoma Variant

Distinction of endometrial stromal sarcomas from ‘hemangiopericytomatous’ tumors using a panel of immunohistochemical stains

Malignant Hemangiopericytoma of the Ovary

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