Hemangiopericytoma of the Nasal Cavity: A Review of 15 Cases over a 40-Year Period

Abstract

Hemangiopericytomas are rare tumors of vascular origin most commonly found in the extremities or retroperitoneal area. When they originatefrom the nasal cavity and paranasal sinuses, they tend to be less aggressive and generall.v do not metastasize. The term "hemangiopericytoma-like lesion" has been coined for sinonasal hemangiopericytomas that display more benign histologic and growth characteristics than do those located elsewhere. Fifteen cases of hemangiopericytoma of the nasal cavity and paranasal sinuses were reviewed over the period 1951 to 1990; included arefol/ow-up data on cases reported earlier from this institution. The clinical course, management, and outcome was evaluated and correlated with the histologic characteristics of the tumors. The recurrence rate in our series was 13.3%; the meanfol/ow-up was 11 years. No patients died of their disease or had evidence a/metastatic disease. This clinicopathologic review suggests that sinonasal hemangiopericytomas should not be classified as "hemangiopericytoma-like" lesions; rather, they should be expected to have significant local recurrence rates with low rates of distant metastasis and mortality. Long-term/ol/ow-up is essential as Rochester, Minnesota

Management of sinonasal hemangiopericytomas: a systematic review

“…After screening, there were a total of 56 articles used that described 128 cases (Fig. ) . The included cases are summarized in Supporting Table .…”

“…CT shows the significant vascularity of these tumors, which is particularly highlighted with contrast, as well as the location, spread, and erosions that may have taken place (Fig. ) . However, CT findings are generally nonspecific, presenting as a unilateral noncalcified lesion that can be confused with other nasal neoplasms, particularly due to the displacement/invasion of adjacent structures .…”

“…) . However, CT findings are generally nonspecific, presenting as a unilateral noncalcified lesion that can be confused with other nasal neoplasms, particularly due to the displacement/invasion of adjacent structures . The majority of cases reviewed involved hemangiopericytomas that occupied more than 1 distinct location in the sinonasal tract, indicating the insidious expansion of these tumors.…”

“…This often shows a classic staghorn vascular appearance due to the numerous vascular channels within these tumors (Fig. ) . Formal diagnosis in the cases within this review was made based on histology, and not nasal endoscopy.…”

“…The prognosis of this condition varies widely, with both the more common benign form and the less frequently reported malignant form identified in the literature. Those that are malignant can metastasize, most often to the lung, though cases have also been seen with metastasis to the brain, bone, and liver . This tumor has also been known to cause a paraneoplastic syndrome, called osteogenic osteomalacia .…”