Hemangiopericytoma of the head and neck

Billings, Kathleen R.; Fu, Yao; Calcaterra, Thomas C.; Sercarz, Joel A.

doi:10.1053/ajot.2000.8378

Cited by 61 publications

(66 citation statements)

References 22 publications

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“…The individual's sex does not influence its incidence. 1,7 Our patient had no past history of trauma, hypertension or prolonged steroid use.…”

Section: Discussionmentioning

confidence: 87%

“…Enzinger reported the following characteristics that are compatible with a high-grade tumor: nuclear atypia, necrosis, hemangioma, presence of more than four mitosis per microscope field and size greater than 6.5 cm. 6,7 However, Stout and Murray 3 did not notice any correlation between the mitosis level and tumor behavior. They noted that the ten-year survival rates of patients with lesions that presented fewer than four mitosis per microscope field, absence of necrosis and size below 6.5 cm were respectively 77%, 81% and 92%.…”

Section: Discussionmentioning

confidence: 92%

“…6,7 In this site, it mostly affects soft tissue around the oral cavity, sinus tract and meninges; and more rarely, it affects the orbit, parotid gland, skull base and temporal bone. 4,[6][7][8] Its peak prevalence is in the sixth to seventh decade of life: it is rare among adolescents or children. The individual's sex does not influence its incidence.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, when the tumor presented more than four mitosis per field, necrosis and size greater than 6.5 cm, the tenyear survival rates were respectively 9%, 29% and 63%. 7 Recurrence indicates a poor prognosis and many such cases develop distant metastasis. Studies have shown metastasis rates ranging from 18% to 69%.…”

Section: Discussionmentioning

confidence: 99%

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Head and neck hemangiopericytoma in a child: case report

et al. 2004

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CONTEXT: Hemangiopericytoma is a relatively rare tumor, first described in 1942, with approximately 300 cases described in the literature to date. In most cases, it affects the trunk and lower extremities. The head and neck incidence is less than 20%, mostly in adults. We describe a case of malignant head and neck hemangiopericytoma in a child. TYPE OF STUDY: Case report. CASE REPORT: A twelve-year-old male patient noted the presence of a firm painless right-side retroauricular lymph node of 1 cm in diameter, which at first remained unchanged for six months, but subsequently enlarged progressively. He denied having had previous trauma at that site. In November 2000, he presented nasal obstruction and voluminous epistaxis that required hospitalization and blood transfusion. During dental treatment one month later, a cranial x-ray revealed bone alterations. A subsequent computed tomography scan showed an extensive lesion of soft tissue density that had invaded the maxillary fossa, eroding the skull base and middle and nasal fossa. The child was then referred to our service, where biopsy was performed, giving a diagnosis of hemangiopericytoma. Shortly afterwards, magnetic resonance imaging revealed that this lesion had undergone significant growth, while maintaining the same invasion pattern. The patient was submitted to conservative surgery in April 2001, with only partial resection of the tumor because of its extent. Histopathological examination of the specimen confirmed the presence of malignant hemangiopericytoma. Following the surgery, the patient presented fast regrowth of the lesion, with partial response to chemotherapy and radiotherapy.

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“…The individual's sex does not influence its incidence. 1,7 Our patient had no past history of trauma, hypertension or prolonged steroid use.…”

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Head and neck hemangiopericytoma in a child: case report

et al. 2004

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“…Thus, adenoid cystic carcinomas of the breast are very rare (0.1-1% of all breast cancers 38 ) and have an excellent prognosis whereas adenoid cystic carcinomas of the salivary glands account for about 10% of epithelial tumors of the salivary glands and are a highly aggressive disease with a high recurrence rate and long-term Salivary gland-like tumors poor survival. 87,88 The differences in clinical behavior are only partly known. Recent studies using high-resolution array-CGH have shown that adenoid cystic carcinomas of the breast have very few or no recurrent copy number alterations in line with their non-aggressive clinical appearance.…”

Section: Discussionmentioning

confidence: 99%

K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

et al. 2013

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Salivary gland-like tumors of the breast show a great variety of architectural patterns and cellular differentiations such as glandular, myoepithelial, squamous, and even mesenchymal phenotypes. However, currently little is known about the evolution and cellular differentiation of these tumors. For that reason, we performed an in situ triple immunofluorescence lineage/differentiation tracing (isTILT) and qRT-PCR study of basal (K5/K14), glandular (K7/K8/18), and epidermal-specific squamous (K10) keratins, p63, and smooth muscle actin (SMA; myoepithelial marker) with the aim to construct and trace different cell lineages and define their cellular hierarchy in tumors with myoepithelial differentiation. isTILT analysis of a series of 28 breast, salivary, and lacrimal gland tumors, including pleomorphic adenomas (n ¼ 8), epithelial-myoepithelial tumors (n ¼ 9), and adenoid cystic carcinomas (n ¼ 11) revealed that all tumor types contained K5/K14-positive progenitor cells in varying frequencies from a few percent up to 15%. These K5/K14-positive tumor cells were found to differentiate to glandular-(K8/18-positive) and myoepithelial-lineage (SMA-positive)-specific cells and were also shown to generate various heterologeous cell differentiations such as squamous and mesenchymal progenies. p63 was co-expressed with K5/K14 in basal-like progenitor cells, myoepithelial, and squamous cells but not in glandular cells. Our results show that the corresponding counterpart tumors of breast and salivary/lacrimal glands have identical cellular compositions. Taken together, our isTILT and RNA-expression data indicate that look-alike tumors of the breast represent a special subgroup of basal-type tumors with benign or usually low malignant potential.

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Pathology Quiz Case 1: Diagnosis

2009

Arch Otolaryngol Head Neck Surg

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Hemangiopericytoma of the head and neck

Cited by 61 publications

References 22 publications

Head and neck hemangiopericytoma in a child: case report

Head and neck hemangiopericytoma in a child: case report

K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

Pathology Quiz Case 1: Diagnosis

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