Hemagglutination Tests and Related Advances in Serodiagnosis of Syphilis

Shore, Ronald N.

doi:10.1001/archderm.1974.01630060032008

Cited by 17 publications

(7 citation statements)

References 21 publications

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“…The lower cost and ease of performance make the MHA-TP assays for treponemal antibodies popular. MHA-TP assays have been proven to be as sensitive as the FTA-ABS test for all stages of syphilis other than the primary stage (14). There is disagreement over the reactivity of MHA-TP tests in primary syphilis.…”

Section: Resultsmentioning

confidence: 99%

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Reactivity of microhemagglutination, fluorescent treponemal antibody absorption, Venereal Disease Research Laboratory, and rapid plasma reagin tests in primary syphilis

Huber¹,

Storms²,

Pl³

et al. 1983

J Clin Microbiol

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Seroreactivity of sera from 109 patients with first-infection primary syphilis was 98.2% in the fluorescent treponemal antibody absorption test, 92.7% in the rapid plasma reagin 18-mm circle card test, 72.5% in the microhemagglutination test (MHA-TP), and 72.5% in the Venereal Disease Research Laboratory test. Seroreactivity of sera from 18 patients with primary syphilis with documented previous infection(s) was 100% in the fluorescent treponemal antibody absorption test, the rapid plasma reagin 18-mm circle card test, and the MHA-TP test and 88.9% in the Venereal Disease Research Laboratory test. The MHA-TP test failed to confirm reactivity in 13 of 79 sera which were reactive in the Venereal Disease Research Laboratory test and in 24 of 101 sera which were reactive in the rapid plasma reagin 18-mm circle card test. Testing another production lot of MHA-TP reagents resulted in even poorer correlation. The reactivity of the MHA-TP test in primary syphilis appeared to vary with the sensitivity of the production lot of reagents.

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Section: Resultsmentioning

confidence: 99%

“…Ns : .A.. NR WR 1:1 1:2 1:4 1: (3,7,8,13,14,16), whereas others reported a higher sensitivity (1, 15). Luger and Spendlingwimmer (9) reported that MHA-TP test reactivity was greater than the FTA-ABS test reactivity in 21 cases of primary syphilis.…”

mentioning

confidence: 98%

Reactivity of microhemagglutination, fluorescent treponemal antibody absorption, Venereal Disease Research Laboratory, and rapid plasma reagin tests in primary syphilis

Huber¹,

Storms²,

Pl³

et al. 1983

J Clin Microbiol

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“…With sensitivity often approaching 100%, the HATTS has fewer problems than the Corzyme test (Shore, 1974;Puckett & Pratt, 1987;Jaffe & Musher, 1990). However, in the early stages of syphilis, the HATTS is relatively insensitive (Jaffe & Musher, 1990;Larsen, Hunter & Creighton, 1990).…”

Section: Hattsmentioning

confidence: 99%

“…While specificity of the HATTS is generally quite high, treponemal tests like the HATTS are reactive in approximately 1% of the cases where individuals have no history or other indications of syphilis. Results of this kind are often transient and appear to be due to a variety of different causes, possibly including pregnancy and infectious mononucleosis (Shore, 1974;Wentworth et al, 1978;Jaffe & Musher, 1990).…”

Section: Hattsmentioning

confidence: 99%

The validity of injecting drug users' self‐reports about sexually transmitted diseases: a comparison of survey and serological data

Kleyn

Schwebke²,

Holmes

1993

Addiction

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Researchers studying the validity of injecting drug users' self-reports have often reported a high degree of correspondence between self-reports and several types of criterion variables. In this study, injecting drug users' responses to questions about prior infection with four sexually transmitted diseases were compared with serological test data. For three of the four diseases studied, discrepancies between survey and serological results were quite large, especially when respondents said they had no previous history of infection. Limitations of serological testing, the questions asked, respondent knowledge and the more traditional concern with respondent veracity are discussed as possible explanations for the observed differences. Study data suggest that use of drug injectors' self-reports to measure infection with sexually transmitted diseases or to validate other measures is a questionable practice. Problems encountered in interpreting study results provide support for more frequent use of experimental or quasi-experimental designs and of multivariate analytic techniques when conducting research on response validity.

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“…These reports, however, do not give sufficient evidence to show whether instances of non-specific positive FTA-ABS results are indeed noted more frequently in pregnant women than in the general population and, if so, whether this detracts from the value of the FTA-ABS technique in confirming reactive results of cardiolipin tests in pregnant women. In some recent reports (Shore, 1974;Kern, 1975;Meyer-Rohn, 1976) certain reservations have been expressed regarding the specificity of the TPHA test in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Specificity of the FTA-ABS and TPHA tests during pregnancy.

Manikowska-Lesińska¹,

Linda²,

Zájac³

1978

Sexually Transmitted Infections

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SUMMARY In order to determine whether pregnancy influences the specificity of the fluorescent treponemal antibody absorption (FTA-ABS) and Treponema pallidum haemagglutination assay (TPHA) tests, these tests, together with the quantitative fluorescent treponemal antibody (FTA) and Venereal Disease Research Laboratory (VDRL) tests, were carried out simultaneously on 2000 pregnant women who attended for compulsory prenatal screening. In only one patient (0 05 % of the total investigated) was a positive result to the TPHA test obtained, the specificity of which it was impossible to confirm. The FTA-ABS test gave a weakly reactive result of the borderline type but this was found to be non-specific in only four (0-2 %) patients. The results of our investigations showed that the specificity of the FTA-ABS and the TPHA tests performed on pregnant women did not differ from the specificity of these tests when carried out on other population groups.

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Hemagglutination Tests and Related Advances in Serodiagnosis of Syphilis

Cited by 17 publications

References 21 publications

Reactivity of microhemagglutination, fluorescent treponemal antibody absorption, Venereal Disease Research Laboratory, and rapid plasma reagin tests in primary syphilis

Reactivity of microhemagglutination, fluorescent treponemal antibody absorption, Venereal Disease Research Laboratory, and rapid plasma reagin tests in primary syphilis

The validity of injecting drug users' self‐reports about sexually transmitted diseases: a comparison of survey and serological data

Specificity of the FTA-ABS and TPHA tests during pregnancy.

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