Hemagglutination inhibiting antibodies and protection against seasonal and pandemic influenza infection

Fox, Annette; Quynh, Lê; Thanh, Le Thị; Wolbers, Marcel; Hằng, Nguyễn Lê Khánh; Thai, Pham Quang; Yen, Nguyen Thi Thu; Hoa, Le Nguyen Minh; Bryant, Juliet E.; Dương, Trần Như; Thoang, Dang Dinh; Barr, Ian G.; Wertheim, Heiman; Farrar, Jeremy; Hiển, Nguyễn Trần; Horby, Peter

doi:10.1016/j.jinf.2014.09.003

Cited by 36 publications

(41 citation statements)

References 51 publications

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“…NAbs clearly mediate protective immunity to influenza (31,32); however, recent studies have suggested that Abs with Fc-mediated functions play an important additive role in protective immunity (11). We recruited subjects with and without underlying HIV infection to receive the 2015 TIV and studied functional Ab responses prior to and after vaccination.…”

Section: Discussionmentioning

confidence: 99%

Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

Kristensen

Lay

Ana-Sosa-Batiz

et al. 2016

J Virol

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Section: Discussionmentioning

confidence: 99%

Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

Kristensen

Lay

Ana-Sosa-Batiz

et al. 2016

J Virol

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“…Influenza serotyping kits were supplied by the World Health Organization Collaborating Centre (WHO-CC) for Influenza Surveillance and Research, Melbourne, Australia [31–33]. …”

Section: Methodsmentioning

confidence: 99%

Epidemiology of influenza B/Yamagata and B/Victoria lineages in South Africa, 2005-2014

et al. 2017

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BackgroundStudies describing the epidemiology of influenza B lineages in South Africa are lacking.MethodsWe conducted a prospective study to describe the circulation of influenza B/Victoria and B/Yamagata lineages among patients of all ages enrolled in South Africa through three respiratory illness surveillance systems between 2005 and 2014: (i) the Viral Watch (VW) program enrolled outpatients with influenza-like illness (ILI) from private healthcare facilities during 2005–2014; (ii) the influenza-like illnesses program enrolled outpatients in public healthcare clinics (ILI/PHC) during 2012–2014; and (iii) the severe acute respiratory illnesses (SARI) program enrolled inpatients from public hospitals during 2009–2014. Influenza B viruses were detected by virus isolation during 2005 to 2009 and by real-time reverse transcription polymerase chain reaction from 2009–2014. Clinical and epidemiological characteristics of patients hospitalized with SARI and infected with different influenza B lineages were also compared using unconditional logistic regression.ResultsInfluenza viruses were detected in 22% (8,706/39,804) of specimens from patients with ILI or SARI during 2005–2014, of which 24% (2,087) were positive for influenza B. Influenza B viruses predominated in all three surveillance systems in 2010. B/Victoria predominated prior to 2011 (except 2008) whereas B/Yamagata predominated thereafter (except 2012). B lineages co-circulated in all seasons, except in 2013 and 2014 for SARI and ILI/PHC surveillance. Among influenza B-positive SARI cases, the detection of influenza B/Yamagata compared to influenza B/Victoria was significantly higher in individuals aged 45–64 years (adjusted odds ratio [aOR]: 4.2; 95% confidence interval [CI]: 1.1–16.5) and ≥65 years (aOR: 12.2; 95% CI: 2.3–64.4) compared to children aged 0–4 years, but was significantly lower in HIV-infected patients (aOR: 0.4; 95% CI: 0.2–0.9).ConclusionB lineages co-circulated in most seasons except in 2013 and 2014. Hospitalized SARI cases display differential susceptibility for the two influenza B lineages, with B/Victoria being more prevalent among children and HIV-infected persons.

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“…Early studies speculated that antibodies elicited against older viral strains were partially protective and that these cross-reactive antibodies reduced susceptibility and the opportunity to develop immunity to new strains [4,5,13]. A robust relationship between pre-existing antibody titers and reduced susceptibility has been repeatedly observed [15–17]. Cross-reactive antibodies elicited by initial infections limit virus replication during secondary viral exposures and reduce disease in experimental infections [18,19].…”

Section: Is Original Antigenic Sin Detrimental?mentioning

confidence: 99%

Immune history and influenza virus susceptibility

Cobey

Hensley

2017

Current Opinion in Virology

226

222

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Antibody responses to influenza viruses are critical for protection, but the ways in which repeated viral exposures shape antibody evolution and effectiveness over time remain controversial. Early observations demonstrated that the history of viral exposures has a profound effect on the specificity and magnitude of antibody responses to a new viral strain, a phenomenon called “original antigenic sin.” Although “sin” might suppress some aspects of the immune response, so far there is little indication that hosts with pre-existing immunity are more susceptible to viral infections compared to naïve hosts. However, the tendency of the immune response to focus on previously recognized conserved epitopes when encountering new viral strains can create an opportunity cost when mutations arise in these conserved epitopes. Hosts with different exposure histories may continue to experience distinct patterns of infection over time, which may influence influenza viruses’ continued antigenic evolution. Understanding the dynamics of B cell competition that underlie the development of antibody responses might help explain the low effectiveness of current influenza vaccines and lead to better vaccination strategies.

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Hemagglutination inhibiting antibodies and protection against seasonal and pandemic influenza infection

Cited by 36 publications

References 51 publications

Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

Epidemiology of influenza B/Yamagata and B/Victoria lineages in South Africa, 2005-2014

Immune history and influenza virus susceptibility

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