Hemagglutination and Complement Fixation with Type I and II Albany Strains of Coxsackie Virus.

Coxsackie Viruses and Bornholm Disease

“…This is in conformity with the negative results obtained by Casals et al (1949). Discussion These investigations show that symptoms of myalgia resembling those seen in Bornholm disease (also known as epidemic myalgia, epidemic myositis, epidemic pleurodynia, epidemic pleurisy) occurred in laboratory personnel during investigations with Coxsackie virus 2 and are followed in a few days by the appearance of positive complement-fixing antibodies in the blood.…”

“…The Complement-fixation Reaction Complement-fixation tests have been carried out in America by Casals et al (1949) and Howitt and Benefield (1950). The following technique has been employed by us.…”

Immunological Reactions in Viral Diseases

“…The Columbia SK-MM-Mengo:-encephalomyocarditis viruses caused agglutination of sheep erythrocytes (122) and again group specific antiserum inhibited the reaction. Seventeen other neurotropic viruses (122) , including certain members of the Coxsackie group (156) , failed to agglutinate erythrocytes derived from eight animal species. Thus a simple in vitro test for the diagnosis of neurotropic viral infections stiII remains applicable to only two groups of viruses.…”

“…from the time the infected tissue is harvested. The same technique was ap plied successfully in preparing antigens from tissues infected with Coxsackie viruses (156).…”

A Viral Agent Isolated From a Case of "Non-Paralytic Poliomyelitis" and Pathogenic for Suckling Mice: Its Possible Relation to the Coxsackie Group of Viruses

“…With other strains, lesions involving the brain and the myocardium and other visceral organs have been mentioned, though not described in detail. Serological evidence suggests the existence of at least several apparently distinct types (6)(7)(8). Since the clinical features of the Worcester cases resembled those exhibited by the patients from whom Dalldorf et al (1) and Meinick et al (2)(3)(4) had isolated their strains, attempts were made to isolate a similar agent from the Worcester cases.…”