“…As is the case with exposure to stress and isolation, learned helplessness activates the HPA response which releases J o u r n a l P r e -p r o o f adrenocorticotrophic hormone (ACTH) and reduced activity in a variety of monoaminergic systems. 61,69 Lockdowns and quarantines initially increase anxiety and then give way to a sense of learned helplessness as people feel powerless to control their environment, 70,71,72 The lack of control over exposure to the virus, and the undependability of personal protective equipment (PPE), masks, testing, ventilators, and work schedules have left many healthcare professionals feeling burned out. 5,6 Most businesses made a successful transition to remote work, but many did not, while unemployment reached historic highs.…”