“…These interventions are particularly important for patients with chronic diseases requiring polypharmacy, a condition which increases the risk of medication-related problems and the difficulty of managing complex regimens. Another population that could benefit from TPE interventions is older adults, who, in addition to experiencing a progressive decline in their physical and cognitive abilities, often experience increased medication-related problems (e.g., due to the prescription of inappropriate medications, overly complex medication regimens, the occurrence of adverse reactions or poor adherence to medications) [25]. Although healthcare professionals may advise on the correct therapeutic behaviour, it is ultimately up to the patient to decide whether or not to take prescribed medications, and when and whether to modify or supplement their pharmacological treatment.…”