Helminth infestations

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00030-9

Cited by 2 publications

(2 citation statements)

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“… 7 , 8 Because CADR may occur with any drug class and mimic other pathologies, confirming the diagnosis is often difficult. 9 Several algorithms for diagnosing CADR by clinical parameters exist, including the Jones algorithm, 10 the Naranjo algorithm, 11 the WHO‐UMC, 12 and a new quantitative algorithm. 13 However, inter‐algorithm disagreement still occurs.…”

Section: Introductionmentioning

confidence: 99%

“… 5 Suggestive histopathologic findings include vacuolar interface dermatitis with superficial perivascular inflammation, the presence of eosinophils or neutrophils, papillary dermal edema, and endothelial swelling of superficial dermal vessels. 1 , 7 , 9 , 15 , 16 , 17 The purpose of this study was to retrospectively analyze the biopsy specimens and medical charts of patients who underwent biopsies initially categorized as SID, with the goal of establishing both histopathologic and clinical associations with this mixed inflammatory pattern.…”

Section: Introductionmentioning

confidence: 99%

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The mixed spongiotic and interface reaction pattern: A study of clinical and histopathologic findings

et al. 2022

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Background: Categorization of biopsy specimens into inflammatory reaction patterns is central to dermatopathologic assessment. Mixed inflammatory patterns are poorly characterized and may represent clinicopathologic challenges. The purpose of this study was to identify clinical and histopathologic findings associated with the mixed spongiotic-interface dermatitis (SID) histopathologic pattern.Methods: Fifty-one institutional biopsy specimens of SID were identified over a 2-year period by retrospective natural language search. Histopathologic and clinical features were identified. Results:The most common histopathologic features associated with SID were mild spongiosis (51%), focal vacuolar interface change (72%), lymphocytic exocytosis (92%), and superficial-dermal lymphocytic infiltrate (94%) with variable eosinophils (61%). Clinically, 80% of subjects presented with a symmetric morbilliform eruption.Polypharmacy (94%), immunosuppression (47%), and history of malignancy (47%) were common. The most common diagnoses were drug reaction (37%), possible drug reaction (12%), and viral exanthem (12%). Drug reaction with eosinophilia and systemic symptoms represented 25% of all confirmed cutaneous adverse drug reactions (CADR). Average time from drug initiation to symptom initiation was 20 days (SD: 22.3, range: 0-90); median disease duration was 25.5 days. Spongiotic vesicles and Langerhans cells were less common in patients with a strong clinicopathologic diagnosis of drug reaction compared to non-drug eruptions (p = 0.04). Conclusions:The mixed SID pattern is commonly encountered in CADR but may represent a more subacute course, implying consideration for inciting medication(s) started before the typical 7-to 14-day window.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The mixed spongiotic and interface reaction pattern: A study of clinical and histopathologic findings

et al. 2022

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Subcutaneous dirofilariasis: a masquerade of a palisaded granulomatous dermatitis

2017

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Dirofilaria species are roundworms responsible for "heartworm" in canines. On occasion, humans are an accidental host, resulting in pulmonary (Dirofilaria immitis) or extrapulmonary (Dirofilaria repens) manifestations. Of the extrapulmonary sites of involvement, subcutaneous involvement is particularly common. We report a case of a 49-year-old female who presented with an erythematous nodule on her shin, which closely resembled necrobiosis lipoidica on histopathologic examination. On closer examination, there were foci of necrosis that harbored segments of the nematode, diagnostic of dirofiliarisis. We present this case to highlight the histopathologic similarities and differences between palisaded necrobiotic conditions and this potentially underrecognized entity.

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Helminth infestations

Cited by 2 publications

References 149 publications

The mixed spongiotic and interface reaction pattern: A study of clinical and histopathologic findings

The mixed spongiotic and interface reaction pattern: A study of clinical and histopathologic findings

Subcutaneous dirofilariasis: a masquerade of a palisaded granulomatous dermatitis

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