HELLP Syndrome and COVID-19; association or accident: A case series

Kumar, Sunil; Madaan, Sparsh; Talwar, Dhruv; Jaiswal, Arpita; Acharya, Neema; Acharya, Sourya

doi:10.4103/jfmpc.jfmpc_1136_21

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…1), as treatment for severe preeclampsia and HELLP involve urgent delivery. The relationship between severe HDP and severe COVID-19 is further complicated due to their similar clinical presentations 34,35 . Moreover, mounting evidence suggests that SARS-CoV-2 infection in pregnancy is an independent risk factor for the subsequent development of preeclampsia 36,37 .…”

Section: Discussionmentioning

confidence: 99%

Respiratory distress in SARS-CoV-2 exposed uninfected neonates followed in the COVID Outcomes in Mother-Infant Pairs (COMP) Study

Man,

Azamor,

Cambou

et al. 2024

Nat Commun

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Respiratory distress (RD) has been reported in SARS-CoV-2 exposed uninfected (SEU) term neonates. Prior studies suggest that prenatal exposure to Coronavirus Disease 19 (COVID-19) may activate an inflammatory cascade in the newborn airway. In this study, we examine the relationship between maternal COVID-19 vaccination and neonatal RD using a longitudinal cohort of mother-infant pairs in Los Angeles, CA. Two-hundred and twenty-one mothers with laboratory confirmed SARS-CoV-2 during pregnancy and 227 exposed fetuses are enrolled in our study. Maternal disease severity and neonatal RD variables were defined based on current accepted clinical criteria. To explore the multifactorial associations between maternal COVID-19 parameters and infant RD, we utilize a multivariable logistic regression model and a proteomic sub-analysis to propose a pathway for the development of RD following in utero exposure to SARS-CoV-2. Unusually high rates of RD are observed in SEU infants (17%). The odds ratio of RD is 3.06 (95% CI:1.08-10.21) in term neonates born to unvaccinated individuals versus those born to individuals vaccinated prior to maternal infection. Proteomic analysis reveals a robust inflammatory response associated with ciliary dysregulation and enhanced IgE production among SEU neonates with RD. Maternal vaccination against COVID-19 reduces the frequency of neonatal RD.

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Section: Discussionmentioning

confidence: 99%

Respiratory distress in SARS-CoV-2 exposed uninfected neonates followed in the COVID Outcomes in Mother-Infant Pairs (COMP) Study

Man,

Azamor,

Cambou

et al. 2024

Nat Commun

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“…Terdapat mekanisme serupa pada COVID-19 dan sindrom HELLP yang mengarah pada komplikasi ibu dan janin yang lebih besar. 17 Selain hipertensi, penyakit jantung koroner dan diabetes mellitus juga diketahui sebagai faktor risiko COVID-19 di Brazil dan di Cina (8,2%). 14,15 Diabetes mellitus meningkatkan kerentanan terhadap infeksi melalui resistensi insulin yang mengurangi aktivitas sel T yang menyebabkan pelemahan respon imun.…”

Section: Hasilunclassified

“…Peningkatan kadar insulin juga dikaitkan dengan peningkatan kejadian protrombotik, yang mana berhubungan dengan keadaan COVID-19 yang lebih berat. 17 Penelitian ini menemukan bahwa mayoritas subjek merupakan ibu hamil mengalami COVID-19 derajat ringan. Proporsi tingkat keparahan COVID-19 pada penelitian ini serupa dengan penelitian lain di New York.…”

Section: Hasilunclassified

Karakteristik dan Luaran Wanita Hamil dengan Covid-19 yang Menjalani Seksio Sesarea

Daneswara,

Bisri,

Halimi

2023

JAOI

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Latar Belakang: Wanita hamil menjadi kelompok yang sangat rentan terpengaruh oleh COVID-19. Namun, karakteristik klinis pada ibu hamil dengan COVID-19 belum diketahui secara pasti. Tujuan: Penelitian ini bertujuan untuk mengetahui karakteristik dan luaran wanita hamil dengan COVID-19 yang melakukan persalinan seksio sesarea di RSUP Dr. Hasan Sadikin. Subjek dan Metode: Penelitian ini adalah deskriptif observasional dengan metode retrospektif pada wanita hamil dengan COVID-19 yang menjalani seksio sesarea di ruang operasi isolasi COVID-19 di RSUP Dr. Hasan Sadikin periode Januari 2020 – Januari 2022. Variabel yang diteliti adalah usia, status paritas, komorbiditas, derajat keparahan COVID-19, teknik anestesi, luaran, dan penyebab kematian ibu. Data yang memenuhi kriteria inklusi dan eksklusi kemudian dianalisis dengan SPSS versi 25.0. Hasil: Didapatkan 132 sampel penelitian. Sebagian besar ibu hamil dengan COVID-19 yang menjalani seksio sesarea berusia <35 tahun (68,9%) dan dengan status paritas multipara (75,8%). Mayoritas ibu hamil tidak memiliki komorbid (68,9%) dengan komorbid terbanyak merupakan preeklampsia (28,7%). Teknik anestesi yang banyak digunakan adalah teknik anestesi spinal (87,9%). Gambaran COVID-19 pada penelitian ini mayoritas merupakan derajat ringan (90,9%) dengan luaran yang baik dengan tingkat mortalitas rendah (3%). Penyebab kematian berupa gagal napas e.c COVID-19 derajat kritis, damage control e.c plasenta previa

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Impact of COVID-19 on pregnancy outcomes during delivery admissions: a nationwide analysis with clinical implications

Virk,

Nasrullah,

Gangu

et al. 2024

Baylor University Medical Center Proceedings

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HELLP Syndrome and COVID-19; association or accident: A case series

Cited by 7 publications

References 8 publications

Respiratory distress in SARS-CoV-2 exposed uninfected neonates followed in the COVID Outcomes in Mother-Infant Pairs (COMP) Study

Respiratory distress in SARS-CoV-2 exposed uninfected neonates followed in the COVID Outcomes in Mother-Infant Pairs (COMP) Study

Karakteristik dan Luaran Wanita Hamil dengan Covid-19 yang Menjalani Seksio Sesarea

Impact of COVID-19 on pregnancy outcomes during delivery admissions: a nationwide analysis with clinical implications

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