Helium-Oxygen in Treatment of Upper Airway Obstruction

Lu, Ta-Shung; Ohmura, Akito; Wong, KK; Hodges, Michael R.

doi:10.1097/00000542-197612000-00020

Cited by 47 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lu et al 4 showed that the peak airway pressure and arterial carbon dioxide tension (Paco,) decreased progressively as the helium concentration increased to 80? : in artificially ventilated dogs subjected to the greatest degree of tracheal constriction compatible with survival.…”

Section: Resultsmentioning

confidence: 99%

Quantitative effects of respired helium and oxygen mixtures on gas flow using conventional oxygen masks

Vater¹,

Hurt²,

Aitkenhead³

1983

Anaesthesia

View full text Add to dashboard Cite

SummaryA model lung system with a variable art$cial constriction was used to quantgy the changes in$ow produced by the addition of helium to the gas mixture in the system. The tracheal concentration of helium obtained when administering 79% helium/21% oxygen to the system via conventional, disposable face masks was determined using a resuscitation dummy. The greatest proportion of the increase in fzow through the orifice occurred at concentrations of helium up to 40%. A tracheal concenrration of 4@/, helium could be obtained with all oxygen masks at fresh gas Jow rates grealer than 8 litres/minute. These Jindings will help to rationalise the administration of 79% helium/2I% oxygen to patients with upper respiratory tract obstruction.

show abstract

Section: Resultsmentioning

confidence: 99%

Quantitative effects of respired helium and oxygen mixtures on gas flow using conventional oxygen masks

Vater¹,

Hurt²,

Aitkenhead³

1983

Anaesthesia

View full text Add to dashboard Cite

show abstract

“…The benefit of heliox itself appeared to be immediate and served as a bridge to support the patient while time and pharmacologic measures took effect and an underlying infection abated. [18][19][20] Because patient responses may vary, we believe that a trial of heliox should be considered when caregivers are confronted with patients with severe airflow obstruction who still have respiratory reserve. The patient must be monitored closely throughout the administration of heliox for acute changes, and blood gas determination or transcutaneous P aCO 2 monitoring should ideally be performed.…”

Section: Discussionmentioning

confidence: 99%

Use of Heliox Delivered via High-Flow Nasal Cannula to Treat an Infant With Coronavirus-Related Respiratory Infection and Severe Acute Air-Flow Obstruction

Morgan¹,

Vukin

Mosakowski³

et al. 2014

Respir Care

View full text Add to dashboard Cite

Heliox, a helium-oxygen gas mixture, has been used for many decades to treat obstructive pulmonary disease. The lower density and higher viscosity of heliox relative to nitrogen-oxygen mixtures can significantly reduce airway resistance when an anatomic upper air-flow obstruction is present and gas flow is turbulent. Clinically, heliox can decrease airway resistance in acute asthma in adults and children and in COPD. Heliox may also enhance the bronchodilating effects of ␤-agonist administration for acute asthma. Respiratory syndromes caused by coronavirus infections in humans range in severity from the common cold to severe acute respiratory syndrome associated with human coronavirus OC43 and other viral strains. In infants, coronavirus infection can cause bronchitis, bronchiolitis, and pneumonia in variable combinations and can produce enough air-flow obstruction to cause respiratory failure. We describe a case of coronavirus OC43 infection in an infant with severe acute respiratory distress treated with heliox inhalation to avoid intubation.

show abstract

“…Turbulent flow conditions prevail in this situation, due to a high Re resulting from reduced airway diameter and the high flow velocity stemming from increased inspiratory efforts. Thus, equation (5) predicts that, for a given DP, flow varies inversely with the square root of density (15). Consequently, breathing He-O 2 should prove beneficial by reducing resistance to flow, thereby decreasing inspiratory muscle load and dyspnea.…”

Section: S Upper Airway Obstructionmentioning

confidence: 99%