Helicobacter species identified in liver from patients with cholangiocarcinoma and hepatocellular carcinoma

Nilsson, Hans‐Olof; Mulchandani, Rupa; Tranberg, Karl‐Göran; Stenram, Unne; Wadström, Torkel

doi:10.1053/gast.2001.21382

Cited by 103 publications

(84 citation statements)

References 8 publications

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“…There are 10 case-control studies on this association (30)(31)(32)(33)(34)(35)(36)(37)(38)(39). All of them, except one (39), describe a significantly greater presence of EHH DNA in the liver tissue of patients with HCC than in healthy subjects (40).…”

Section: Hepatocarcinomamentioning

confidence: 99%

Enterohepatic Helicobacter other than Helicobacter pylori

Mateos-Muñoz

Pérez-de-la-Serna

Ruiz-de-León

et al. 2013

Rev. esp. enferm. dig.

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The Helicobacter genus includes Gram negative bacteria which were originally considered to belong to the Campylobacter genus. They have been classified in a separate genus since 1989 because they have different biochemical characteristics, with more than 24 species having been identified and more still being studied.H. pylori is the best known. It has an important etiopathogenic role in peptic ulcer disease and gastric cancer. Enterohepatic Helicobacters (EHH) other than H. pylori colonize the bowel, biliary tree and liver of animals and human beings with pathogenic potential. The difficulties existing to correctly isolate these microorganisms limit the description of their true prevalence and of the diseases they cause. Many studies have tried to discover the different clinical implications of EHH. Diseases like chronic liver disease, autoimmune hepatitis, hepatocarcinoma, autoimmune hepatobiliary disease, biliary lithiasis, cholangiocarcinoma and gallbladder cancer, Meckel´s diverticulum, acute appendicitis and inflammatory bowel disease have been related with different EHH species with different results, although their prevalence is greater than in healthy subjects. However, these data are currently not sufficient to draw definitive conclusions. Finally, the best known role of EHH in bowel disease is production of acute and chronic diarrhea pictures initially referred to as Campylobacter. H. pullorum has been identified in patients with acute gastroenteritis. The correct identification of EHH as producers of infectious gastroenteritis is found in its antibiotic susceptibility. It is generally macrolidesusceptible and quinolone-resistant.

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Section: Hepatocarcinomamentioning

confidence: 99%

Enterohepatic Helicobacter other than Helicobacter pylori

Mateos-Muñoz

Pérez-de-la-Serna

Ruiz-de-León

et al. 2013

Rev. esp. enferm. dig.

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“…To date, the possible association between HCC and helicobacter has been supported by a number of diverse observations which can be summarized as follows. First, based on serological studies as well as direct detection in liver tissues, Helicobacter is more common in those with cirrhosis than non-cirrhosis and, of those with cirrhosis, positive serology is found more frequently in those who have HCC [9][10][11][12][13][14][15][16]19]. Secondly, helicobacter DNA in HCC tissues has been reported from multiple geographic locations.…”

Section: Discussionmentioning

confidence: 99%

“…Since that time, a growing body of literature has suggested a role for Helicobacter in human HCC. Specifically, individuals with HCC are more likely to have serological evidence for past Helicobacter infection [5][6][7][8] and Helicobacter DNA can be found in HCC tissues more commonly than controls [9][10][11][12][13][14][15][16]. In addition to HCC, Helicobacter DNA has also been reported in intrahepatic cholangiocarcinomas [9,12].…”

Section: Introductionmentioning

confidence: 99%

Low frequency of Helicobacter DNA in benign and malignant liver tissues from Baltimore, United States

Vivekanandan

Torbenson

2008

Human Pathology

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Helicobacter DNA has been reported in hepatocellular carcinoma tissues in several studies from varying geographical locations, raising the possibility that helicobacter infection may contribute to the pathogenesis of hepatocellular carcinoma. Other known risk factors for hepatocellular carcinoma show significant geographical variability, but whether the same holds for helicobacter is unknown. We studied the prevalence of Helicobacter DNA in a United States cohort of HCC, where the prevalence of helicobacter infection is low in the general population. Liver tissues from 57 individuals were examined. Thirty-five individuals had paired tumor/non-tumor samples, including 21 cases of hepatocellular carcinoma, for a total of 92 samples studied. Both Helicobacter genus and Helicobacter pylori species specific PCR was performed. Helicobacter DNA was detected in 5/57 (9%) cases, all in non-neoplastic cirrhotic liver tissues from individuals with hepatitis C infection (N=4) or alcohol liver disease (N=1). Tissues from 22 hepatocellular carcinomas and 10 cholangiocarcinomas were all negative as were tissues from 8 benign primary hepatic tumors. In conclusion, Helicobacter DNA was detectable in 9% of liver tissues in this cohort, but was not found in primary benign or malignant liver tumors. These findings indicate that Helicobacter infection is unlikely to be etiologically associated with hepatocellular carcinoma in this cohort. If Helicobacter infection does contribute to the development of hepatocellular carcinoma in general, then significant regional variability must exist.

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“…The most common bacterial DNA sequences found in the patients' liver was H.pylori DNA, by using PCR amplification (Nilsson et al, 2001). …”

Section: Soheir S Abd El-salam Et Almentioning

confidence: 99%

“…Helicobacter species existed in the hepatic tissue of hepatitis C virus, and have been related to hepatocellular carcinoma evolution in the non-fibrotic liver (Meyer-ter-Venn et al, 2001;Vakil et al, 2000 andNilsson et al, 2001). …”

Section: It Was Supposed Thatmentioning

confidence: 99%

Study the Association of Helicobacter pylori and some of Hepatitis C Virus Patients in Egypt

El-Salam

Darwish

Elagawy

2017

Egypt. J. Microbiol.

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B OTH hepatitis C virus and Helicobacter pylori infections are commonly found in Egypt. Correlation among Helicobacter pylori and HCV has been assisted. This work aim was to research H. pylori DNA inside the liver tissue of Egyptian suffers with persistent hepatitis C and find the relation among HP invasion and HCV.This prospective study was conducted with 49 participants. Helicobacter pylori Standard Kit (H.pylori) genome is designed for the in vitro H.pylori genomes from liver tissues patients with chronic hepatitis C quantitatively. A TaqMan® principle was used by the primer and probe. During PCR amplification, primers of bidirectional hybridize to the H.pylori DNA. DNA probe was Labeled with a 5`-dye and a 3`-quencher forms the fluorogenic probe. During PCR amplification, the indicator dye and the quencher are separated and the probe is split. The increase in fluorescence can be detected by PCR platforms.

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Helicobacter species identified in liver from patients with cholangiocarcinoma and hepatocellular carcinoma

Cited by 103 publications

References 8 publications

Enterohepatic Helicobacter other than Helicobacter pylori

Enterohepatic Helicobacter other than Helicobacter pylori

Low frequency of Helicobacter DNA in benign and malignant liver tissues from Baltimore, United States

Study the Association of Helicobacter pylori and some of Hepatitis C Virus Patients in Egypt

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