Helicobacter pylori the Latent Human Pathogen or an Ancestral Commensal Organism

Li, Jackie; Perez-Perez, Guillermo I.

doi:10.3389/fmicb.2018.00609

Cited by 32 publications

(20 citation statements)

References 41 publications

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“…Main outcome of this review was that the vast majority of investigated papers reported a positive association between gastrointestinal microbiota and deterioration of AD. The most common reported microorganism was Hp, one of the identified bacterial pathogens in humans which its role is principally as a pathogen or a commensal [25]. Interestingly, a wide variety of different proposals for the pathogenesis have been reported by the authors of the reviewed articles, such as chronic inflammation, immunological mechanisms, apoptosis, disruption of BBB, intestinal dysbiosis and MetS-related atherosclerosis.…”

Section: Resultsmentioning

confidence: 99%

Alzheimer’s disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement

Doulberis

Kotronis

Gialamprinou

et al. 2020

International Journal of Neuroscience

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Background: Alzheimer disease (AD) is a leading cause of global burden with great impact on societies. Although research is working intensively on promising therapy, the problem remains up-to-date. Among the various proposed hypotheses regarding causality and therapy, emerging evidence supports the hypothesis that gastrointestinal microbiota through the so-called 'gut-brain axis' interacts with immune system and brain and shape the balance between homeostasis and disease; the involvement of gastrointestinal microbiota in the pathophysiology of AD is less defined, even though the role of 'gut-brain axis' has been well verified for other neurodegenerative conditions.Methods: We performed a systematic review of PubMed/MEDLINE database from 1 st January 1990 to 17 th October 2018, to investigate the accessible literature regarding possible association between AD and gastrointestinal microbiota. Inclusion criteria were available full text in English language, original clinical papers implicating AD patients and any sort of gastrointestinal microbiota.Results: Through our query, an initial number of 241 papers has been identified. After removing duplicates and through an additional manual search, twenty-four papers met our inclusion criteria. The great majority of eligible publications supported a possible connection between AD and gastrointestinal microbiota. The most common investigated microorganism was Helicobacter pylori.Conclusion: Our own systematic review, showed a possible association between AD and gastrointestinal microbiota mainly including Helicobacter pylori, and thus further research is required for substantiation of causality as well as for the establishment of promising novel therapies.

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Section: Resultsmentioning

confidence: 99%

Alzheimer’s disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement

Doulberis

Kotronis

Gialamprinou

et al. 2020

International Journal of Neuroscience

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“…There is evidence that H. pylori may confer benefits to humans [75]. There is a growing body of work suggesting that H. pylori may behave like a commensal or a symbiont, depending upon the circumstances [76–78]. The data on the potential importance of H. pylori to human health are discussed in the review article by Cover T. and Blaser M. [79].…”

Section: Discussionmentioning

confidence: 99%

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak

Дорошкевич

Середавкина

et al. 2019

International Journal of Rheumatology

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Background. The nature and rate of gastric mucosal (GM) damage in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) remain to be among the unsolved problems. Objective. To define the role of H. pylori and drugs in the development of GM damages in SLE and APS. Methods. A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum. The presence of H. pylori in the gastric biopsy specimens was determined using polymerase chain reaction. Results. Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of H. pylori. The use of glucocorticoid, low-dose acetylsalicylic acid, nonsteroidal anti-inflammatory drug, and anticoagulant in SLE and APS patients is accompanied by GM damage. Conclusion. There was no evidence of the role of H. pylori in GM damage in the SLE and APS patients. More frequent detection of H. pylori was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones.

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“…For instance, while Marino et al (2019) associates gastric ulceration with Helicobacter pylori infections using a 1994 citation concerned with humans (Nomura et al, 1994), this assertion ignores research over the last quarter century that indicates that Helicobacter spp. can be a commensal organism in humans (Li & Perez-Perez, 2018) and other species (Terio et al, 2005;Yasuda et al, 2015) and that both captive and wild healthy cetaceans harbor Helicobacter spp. (Goldman et al, 2011).…”

Section: Are Killer Whales' Physical Needs Met Under Human Care?mentioning

confidence: 99%

Distinguishing personal belief from scientific knowledge for the betterment of killer whale welfare – a commentary

Kathleen¹,

Heather²,

Zaccaroni³

et al. 2020

IJCP

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We contest publication of Marino et al. regarding captive killer whale (Orcinus orca) welfare because of misrepresentations of available data and the use of citations that do not support assertions. Marino et al. misrepresent stress response concepts and erroneously cite studies, which appear to support Marino et al.’s philosophical beliefs regarding the cetacean hypothalamic–pituitary–adrenal axis. To be clear, these misrepresentations are not differences of scientific opinion, as the authors’ conclusions lack any scientific basis. More extensive review of Marino et al.’s citations reveal a dearth of empirical evidence to support their assertions. Further, Marino et al.’s approach to animal welfare is not consistent with conventional veterinary approaches to animal welfare, including their apparent opposition to use of preventative and therapeutic veterinary interventions. While Marino et al. argue that killer whales’ cognitive and spatial needs preclude management of this species under human care, misrepresentation of the citations used to support this opinion invalidates their arguments. Misleading interpretations of data relative to killer whales’ cognitive and emotional needs and specious and unsubstantiated comparisons with states experienced by humans with posttraumatic stress disorder and other conditions, represent a number of strategies used to misrepresent knowledge regarding killer whale welfare. These misrepresentations and fallacies are inconsistent with scientific ethical standards for credible, peer-reviewed journals (ICMJE, 2018), and are barriers to rigorous discourse and identification of strategies for optimizing killer whale welfare. Assertions in the paper amount to nothing more than a compilation of conclusory, philosophical statements. We would also like to mention that manuscripts such as Marino et al.’s do great damage to the fields of comparative psychology and to behavioral science as a whole.

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Helicobacter pylori the Latent Human Pathogen or an Ancestral Commensal Organism

Cited by 32 publications

References 41 publications

Alzheimer’s disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement

Alzheimer’s disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Distinguishing personal belief from scientific knowledge for the betterment of killer whale welfare – a commentary

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